Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jeffrey M. Eng"'
Publikováno v:
Journal of Pediatric Urology. 9:e72-e75
We report a case of an adolescent who presented with a deep vein thrombosis (DVT) and clinical findings consistent with May–Thurner Syndrome. Specific imaging demonstrated direct compression of the left common iliac vein by an overlying pelvic kidn
Autor:
Daniel H.D. Gray, Marcel R.M. van den Brink, Onder Alpdogan, Richard L. Boyd, Sydney X. Lu, Neel Patel, Odette M. Smith, Stephanie J. Muriglan, David Suh, Gabrielle L. Goldberg, Adam A. Kochman, Vanessa M. Hubbard, Jared Feinman, Jeffrey M. Eng
Publikováno v:
Blood. 107:2453-2460
Keratinocyte growth factor (KGF) is a member of the fibroblast growth factor family that mediates epithelial cell proliferation and differentiation in a variety of tissues, including the thymus. We studied the role of KGF in T-cell development with K
Autor:
Kartono H. Tjoe, Theis H. Terwey, Jeffrey M. Eng, Lucy M. Willis, Chen Liu, George F. Murphy, Marcel R.M. van den Brink, G. Heller, Adam A. Kochman, Rafaella Schiro, Teresa Ramirez-Montagut, Stephanie J. Muriglan, Vanessa M. Hubbard, Onder Alpdogan
Publikováno v:
Blood. 106:3285-3292
Inducible costimulator (ICOS) is expressed on activated and memory T cells and is involved in the regulation of cytokine production. We studied the role of ICOS on alloreactive T cells in graft versus host disease (GVHD) and determined that ICOS expr
Autor:
George J. Murphy, Lucy M. Willis, Marcel R.M. van den Brink, Chen Liu, Aleksandra Petrovic, Barry J. Kappel, Onder Alpdogan, Andrew S. Greenberg, Glenn Heller, Jeffrey M. Eng
Publikováno v:
Blood. 103:1542-1547
Lymphocyte Peyer patch adhesion molecule (LPAM) or alpha(4)beta(7) integrin is expressed on lymphocytes and is responsible for T-cell homing into gut-associated lymphoid tissues through its binding to mucosal addressin cell adhesion molecule (MAdCAM)
Autor:
Onder, Alpdogan, Stephanie J, Muriglan, Jeffrey M, Eng, Lucy M, Willis, Andrew S, Greenberg, Barry J, Kappel, Marcel R M, van den Brink
Publikováno v:
Journal of Clinical Investigation. 112:1095-1107
We used clinically relevant murine allogeneic bone marrow transplantation (BMT) models to study the mechanisms by which IL-7 administration can improve posttransplant peripheral T cell reconstitution. After transplant we could distinguish two populat
Autor:
Andrew S. Greenberg, Lucy M. Willis, Ekaterina Doubrovina, Jeffrey M. Eng, Jimmy A. Rotolo, Raffaella Schiro, Richard J. O'Reilly, Barry J. Kappel, Onder Alpdogan, Cornelius Schmaltz, Marcel R.M. van den Brink, Stephanie J. Muriglan
Publikováno v:
Transplantation. 75:1977-1983
Background. Prolonged immunodeficiency after allogeneic bone marrow transplantation (allo BMT) results in significant morbidity and mortality from infection. Previous studies in murine syngeneic BMT models have demonstrated that posttransplantation i
Autor:
Jennifer Ongchin, Andrew S. Greenberg, George F. Murphy, Cornelius Schmaltz, Jacques J. Peschon, Marcel R.M. van den Brink, Onder Alpdogan, Jimmy A. Rotolo, James M. Crawford, Barry J. Kappel, Henning Walczak, Jeffrey M. Eng, Lucy M. Willis, Hideo Yagita, Stephanie J. Muriglan
Publikováno v:
Nature Medicine. 8:1433-1437
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that exhibits specific tumoricidal activity against a variety of tumors. It is expressed on different cells of the immune system and plays a role
Autor:
Miguel-Angel Perales, Vanessa M. Hubbard, Adi Diab, Alan N. Houghton, Adam A. Kochman, Manuel E. Engelhorn, Fariborz Mortazavi, Jedd D. Wolchok, Onder Alpdogan, Marcel R.M. van den Brink, Jeffrey M. Eng, Theis H. Terwey, Adam D. Cohen, Deonka Huggins, José A. Guevara-Patiño, Glenn Heller
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 177(6)
Malignant relapse remains a major problem for recipients of allogeneic hemopoietic stem cell transplantation (HSCT). We hypothesized that immunization of allogeneic HSCT recipients against tissue-restricted Ags using DNA vaccines would decrease the r
Autor:
Theo D. Kim, Glenn Heller, Marcel R.M. van den Brink, Jeffrey M. Eng, Chen Liu, Theis H. Terwey, Vanessa M. Hubbard, Sydney X. Lu, Elisha Waldman, George F. Murphy, Stephanie J. Muriglan, Adam A. Kochman, Onder Alpdogan
Publikováno v:
Blood. 107(4)
The alpha4beta7 integrin plays a central role in the homing of T cells to the gut. We hypothesized that absence of the beta7 subunit would result in a reduction of intestinal graft-versus-host disease (GVHD) and an improvement in overall GVHD morbidi
Autor:
Eric G. Pamer, G. Heller, Javier Pinilla-Ibarz, Jeffrey M. Eng, David A. Scheinberg, Adam A. Kochman, Marcel R.M. van den Brink, Ingrid Leiner, Barry J. Kappel, Vanessa M. Hubbard
Publikováno v:
Blood. 107(5)
Major histocompatibility complex (MHC) molecules carrying selected peptides will bind specifically to their cognate T-cell receptor on individual clones of reactive T cells. Fluorescently labeled, tetrameric MHC-peptide complexes have been widely use