Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Jeffrey M. Chen"'
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 197 (2022)
UDP-galactopyranose mutase (UGM) is an essential enzyme involved in the bacterial cell wall synthesis, and is not present in mammalian cells. Thus, UGM from Mycobacterium tuberculosis (Mtb) represents a novel and attractive drug target for developing
Externí odkaz:
https://doaj.org/article/ed15a3e25e424bc09d3063742b997473
Autor:
Jeffrey M. Chen
Publikováno v:
mBio, Vol 7, Iss 6 (2016)
ABSTRACT Since their discovery as important determinants of virulence and growth, the type VII ESX secretion systems (ESX-1 to ESX-5) of slow-growing pathogenic mycobacteria have been the focus of intense scrutiny. Genetic studies have been instrumen
Externí odkaz:
https://doaj.org/article/2c7dfe8a9e8743d4aa0aa718cfb229de
Publikováno v:
ACS Infectious Diseases. 7:273-280
Mycobacterium tuberculosis (M. tb) uses its type-7 secretion system ESX-1 to translocate key virulence effector proteins. Taking a chemical genetics approach, we demonstrate for the first time the importance of mycobacterial proteostasis to ESX-1. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1fcbec45f8fc99f4957f077f20b98ab
https://doi.org/10.1021/acsinfecdis.0c00741
https://doi.org/10.1021/acsinfecdis.0c00741
Publikováno v:
J Bacteriol
The Mycobacterium tuberculosis type-7 protein secretion system ESX-1 is a major driver of its virulence. While the functions of most ESX-1 components are characterized, many others remain poorly defined. In this study, we examined the role of EspK, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1988e905dd0d0691127d40f6e7d4f242
https://pubmed.ncbi.nlm.nih.gov/35315684
https://pubmed.ncbi.nlm.nih.gov/35315684
Publikováno v:
Innate Immunity
The cell envelope of pathogenic mycobacteria interfaces with the host. As such, the interaction of bacterial products localized at or released from the cell surface with the host’s immune system can determine the fate of the bacterium in its host.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2e13f98acc81b5a90896c5ca7bb0b4f
http://europepmc.org/articles/PMC7491241
http://europepmc.org/articles/PMC7491241
Autor:
Kylee Drever, Ze Long Lim, Volker Gerdts, Jeffrey M. Chen, Stewart Walker, Slim Zriba, Yanyun Huang, Nirajan Niroula
Domestic pigs share many similarities with humans in their pulmonary anatomy, physiology, and immunology. Accordingly, pigs have been shown to be valuable models to study human tuberculosis (TB). Here we examined the outcome of disease in domestic pi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dd66d8be534aa7c0a8dd2fbe671962b
https://doi.org/10.1101/2021.10.25.465759
https://doi.org/10.1101/2021.10.25.465759
Autor:
Keith D. MacKenzie, Yejun Wang, Nancy J. Herman, Aaron White, Jeffrey M. Chen, Akosiererem S. Sokaribo, Melissa B. Palmer, Madeline C. McCarthy, Beatrice Chung, Lindsay R. Balezantis
Publikováno v:
Infection and Immunity. 89
Non-typhoidal Salmonella (NTS) strains are associated with gastroenteritis worldwide but are also the leading cause of bacterial bloodstream infections in sub-Saharan Africa. The invasive NTS (iNTS) strains that cause bloodstream infections differ fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6603314684799397dc50c222a4429b2e
https://doi.org/10.1128/iai.00810-20
https://doi.org/10.1128/iai.00810-20
Publikováno v:
ACS infectious diseases. 7(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::01ec2ddb39f80482e661d0af65c1b7ee
https://pubmed.ncbi.nlm.nih.gov/33534536
https://pubmed.ncbi.nlm.nih.gov/33534536
Autor:
Akosiererem S, Sokaribo, Lindsay R, Balezantis, Keith D, MacKenzie, Yejun, Wang, Melissa B, Palmer, Beatrice, Chung, Nancy J, Herman, Madeline C, McCarthy, Jeffrey M, Chen, Aaron P, White
Publikováno v:
Infect Immun
Nontyphoidal Salmonella (NTS) strains are associated with gastroenteritis worldwide but are also the leading cause of bacterial bloodstream infections in sub-Saharan Africa. The invasive NTS (iNTS) strains that cause bloodstream infections differ fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2063ad8bc5523a764882a9c1af9685a3
https://pubmed.ncbi.nlm.nih.gov/33468583
https://pubmed.ncbi.nlm.nih.gov/33468583
Autor:
Nirajan Niroula, Ze Long Lim, Stewart Walker, Yanyun Huang, Volker Gerdts, Slim Zriba, Kylee Drever, Jeffrey M. Chen
Publikováno v:
Tuberculosis. 133:102167
The domestic pig shares many similarities with humans in anatomy, physiology, and immunology. As such it is an attractive animal model to study human tuberculosis (TB). In this study, we examined disease outcome in pigs challenged via two different r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef4c4e0984623fbd0129dbd18283c812
https://doi.org/10.1016/j.tube.2022.102167
https://doi.org/10.1016/j.tube.2022.102167