Zobrazeno 1 - 10
of 468
pro vyhledávání: '"Jeffrey M Witkin"'
Publikováno v:
Future Pharmacology, Vol 4, Iss 3, Pp 494-509 (2024)
Ampakines are a class of orally available positive allosteric modulators of the AMPA-glutamate receptor (AMPAR) and have therapeutic implications for neurological/neuropsychiatric disorders in which AMPAR signaling is compromised. Low-impact ampakine
Externí odkaz:
https://doaj.org/article/64ab3660dce846598b9b47f1d4571137
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Traumatic brain injury (TBI) has reached epidemic proportions worldwide. The consequences of TBI can be severe even with repetitive mild trauma. If death and coma are avoided, the consequences of TBI in the long term typically involve dizziness, slee
Externí odkaz:
https://doaj.org/article/edce5b3f28144b75b17192ba92008c1f
Autor:
Daniel Pierce Radin, Sheng Zhong, Rok Cerne, Mohammed Shoaib, Jeffrey M. Witkin, Arnold Lippa
Publikováno v:
Future Pharmacology, Vol 4, Iss 1, Pp 173-187 (2024)
AMPA-glutamate receptors (AMPARs) are expressed throughout the CNS and mediate the majority of fast excitatory synaptic transmission. Ampakines are orally available small molecules that bind allosterically to AMPARs and enhance excitatory currents el
Externí odkaz:
https://doaj.org/article/f0c6232b2cb84a4db749d1ea71f2646a
Autor:
Hana Shafique, Julie C. Demers, Julia Biesiada, Lalit K. Golani, Rok Cerne, Jodi L. Smith, Marta Szostak, Jeffrey M. Witkin
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6804 (2024)
NMDA receptor antagonists have potential for therapeutics in neurological and psychiatric diseases, including neurodegenerative diseases, epilepsy, traumatic brain injury, substance abuse disorder (SUD), and major depressive disorder (MDD). (S)-ketam
Externí odkaz:
https://doaj.org/article/94ab1d8cc61948f5a50dff7a0f651876
Autor:
Jodi L. Smith, Jeremy Wertz, Arnold Lippa, Xingjie Ping, Xiaoming Jin, James M. Cook, Jeffrey M. Witkin, Rok Cerne
Publikováno v:
Heliyon, Vol 10, Iss 1, Pp e23752- (2024)
A clinical case of a 19-year-old male patient with pharmacoresistant seizures occurring following parieto-occipital tumor-resection at age 6 is described. Seizure surgery work-up included prolonged video EEG monitoring and head CT without contrast. S
Externí odkaz:
https://doaj.org/article/0e27875a91dd4592b3e8138eaae731dd
Autor:
Dishary Sharmin, Md Yeunus Mian, Michael Marcotte, Thomas D. Prevot, Etienne Sibille, Jeffrey M. Witkin, James M. Cook
Publikováno v:
Molecules, Vol 28, Iss 12, p 4771 (2023)
GABA mediates inhibitory actions through various GABAA receptor subtypes, including 19 subunits in human GABAAR. Dysregulation of GABAergic neurotransmission is associated with several psychiatric disorders, including depression, anxiety, and schizop
Externí odkaz:
https://doaj.org/article/acec2607b20b4845bf8d9d92e46a9997
Autor:
Barbara Kosmowska, Martyna Paleczna, Dominika Biała, Justyna Kadłuczka, Jadwiga Wardas, Jeffrey M. Witkin, James M. Cook, Dishary Sharmin, Monika Marcinkowska, Katarzyna Z. Kuter
Publikováno v:
Biomolecules, Vol 13, Iss 2, p 197 (2023)
Treatment of tremors, such as in essential tremor (ET) and Parkinson’s disease (PD) is mostly ineffective. Exact tremor pathomechanisms are unknown and relevant animal models are missing. GABA-A receptor is a target for tremorolytic medications, bu
Externí odkaz:
https://doaj.org/article/cca5c71e26cb420fbf6d242daa10c8b2
Autor:
Xingjie Ping, Michelle J. Meyer, Nicolas M. Zahn, Lalit K. Golani, Dishary Sharmin, Kamal P. Pandey, Sepideh Revanian, Prithu Mondal, Xiaoming Jin, Leggy A. Arnold, Rok Cerne, James M. Cook, Branka Divović, Miroslav M. Savić, Arnold Lippa, Jodi L. Smith, Jeffrey M. Witkin
Publikováno v:
Drug Development Research
A series of imidazodiazepines has been developed that possess reduced sedative liabilities but retain efficacy in anticonvulsant screening models. The latest of these compounds, (5-(8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazole[1,5-α][1,4]diazepin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd92e068ef9c959ec71ac2decf0fe410
https://doi.org/10.1002/ddr.22042
https://doi.org/10.1002/ddr.22042
Autor:
Kamal P. Pandey, Branka Divović, Farjana Rashid, Lalit K. Golani, Rok Cerne, Nicolas M. Zahn, Michelle Jean Meyer, Leggy A. Arnold, Dishary Sharmin, Md Yeunus Mian, Jodi L. Smith, Xingjie Ping, Xiaoming Jin, Arnold Lippa, V.V.N. Phani Babu Tiruveedhula, James M. Cook, Miroslav M. Savić, Jeffrey M. Witkin
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 385:50-61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79150d8e7e1712b0c4f2b466b3c9c84f
https://doi.org/10.1124/jpet.122.001362
https://doi.org/10.1124/jpet.122.001362
Autor:
Cook, Dishary Sharmin, Md Yeunus Mian, Michael Marcotte, Thomas D. Prevot, Etienne Sibille, Jeffrey M. Witkin, James M.
Publikováno v:
Molecules; Volume 28; Issue 12; Pages: 4771
GABA mediates inhibitory actions through various GABAA receptor subtypes, including 19 subunits in human GABAAR. Dysregulation of GABAergic neurotransmission is associated with several psychiatric disorders, including depression, anxiety, and schizop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::d03305460ff6816a667c06f6ebf301ae