Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jeffrey M Lynch"'
Autor:
Jeffrey M Lynch, Andrew J Dolman, Chenying Guo, Katie Dolan, Chuanxi Xiang, Samir Reda, Bing Li, Ganesh Prasanna
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206801 (2018)
Myocilin (MYOC) is the gene with mutations most common in glaucoma. In the eye, MYOC is in trabecular meshwork, ciliary body, and retina. Other tissues with high MYOC transcript levels are skeletal muscle and heart. To date, the function of wild-type
Externí odkaz:
https://doaj.org/article/4d38d4da0c064d5ca851f3a420ffc156
Autor:
Robert N. Correll, Jeffrey M. Lynch, Tobias G. Schips, Vikram Prasad, Allen J. York, Michelle A. Sargent, Didier X. P. Brochet, Jianjie Ma, Jeffery D. Molkentin
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Transverse tubules (t-tubules) are uniquely-adapted membrane invaginations in cardiac myocytes that facilitate the synchronous release of Ca2+ from internal stores and subsequent myofilament contraction, although these structures become diso
Externí odkaz:
https://doaj.org/article/e0793bad17014a878298a6f75b5f43f6
Autor:
Hadi Khalil, Robert N. Correll, Kelly M. Grimes, Jeffrey M. Lynch, Vikram Prasad, Jeffery D. Molkentin
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific Reports
Scientific Reports
Hemodynamic stress on the mammalian heart results in compensatory hypertrophy and activation of the unfolded protein response through activating transcription factor 6α (ATF6α) in cardiac myocytes, but the roles of ATF6α or the related transcripti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6164d547216813a3ef4a900f4c17b0
http://link.springer.com/article/10.1038/s41598-019-39515-5
http://link.springer.com/article/10.1038/s41598-019-39515-5
Autor:
Barrett Leehy, Hong Lei, Jeffrey M. Lynch, Veronica Saenz-Vash, Chuanxi Xiang, Parvaneh Katoli, Ganesh Prasanna, Erik Meredith, Bing Li, Dennis S Rice, Amy Chen, Y. Karen Wang, Thomas B. Nicholson, Nalini Rangaswamy
Publikováno v:
Journal of Biological Chemistry. 293:20137-20156
Myocilin (MYOC) was discovered more than 20 years ago and is the gene whose mutations are most commonly observed in individuals with glaucoma. Despite extensive research efforts, the function of WT MYOC has remained elusive, and how mutant MYOC is li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae3826f777c3f3a0f945d85cd54ed32
https://doi.org/10.1074/jbc.ra118.004325
https://doi.org/10.1074/jbc.ra118.004325
Autor:
Andrew Anh Nguyen, Jeffrey M. Lynch, Erik Meredith, Y. Karen Wang, Parvaneh Katoli, Adarsh Godbole, Veronica Saenz-Vash, Kirk Clark, Nancy Lewicki, Michael J. Romanowski
Publikováno v:
Protein Expression and Purification. 147:38-48
Myocilin (MYOC) is a secreted protein found in human aqueous humor (AH) and mutations in the MYOC gene are the most common mutation observed in glaucoma patients. Human AH analyzed under non-reducing conditions suggests that MYOC is not normally foun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af4802c86d80d166047463064e8474d
https://doi.org/10.1016/j.pep.2018.02.008
https://doi.org/10.1016/j.pep.2018.02.008
Autor:
Chuanxi Xiang, Ganesh Prasanna, Samir Reda, Bing Li, Andrew Dolman, Chenying Guo, Katie Dolan, Jeffrey M. Lynch
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206801 (2018)
PLoS ONE
PLoS ONE
Myocilin (MYOC) is the gene with mutations most common in glaucoma. In the eye, MYOC is in trabecular meshwork, ciliary body, and retina. Other tissues with high MYOC transcript levels are skeletal muscle and heart. To date, the function of wild-type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abff3db2988f5d5663347e9c1ef3d88a
http://europepmc.org/articles/PMC6218065?pdf=render
http://europepmc.org/articles/PMC6218065?pdf=render
Publikováno v:
Circulation Research. 121
The endoplasmic reticulum (ER) stress response is one of many signaling events activated in the heart in response to injury and/or cardiac hypertrophy, although the role that this response pathway plays in such events remains under investigation. Rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc919bfc6371e852c5362f43bac976db
https://doi.org/10.1161/res.121.suppl_1.155
https://doi.org/10.1161/res.121.suppl_1.155
Publikováno v:
American Journal of Gastroenterology. 114:S598-S598
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dae28f2bd58faf5c47f9083999cea70a
https://doi.org/10.14309/01.ajg.0000593748.84366.f6
https://doi.org/10.14309/01.ajg.0000593748.84366.f6
Autor:
Tetsuya Okada, Jeffrey Robbins, Jeffrey M. Lynch, Ron Prywes, Kaari A. Lynch, Davy Vanhoutte, Michelle A. Sargent, Jack Lawler, Kazutoshi Mori, Aryn Schloemer, Hanna Osinska, Jeffery D. Molkentin, N. Scott Blair, Bruce J. Aronow, John N. Lorenz, Marjorie Maillet
Publikováno v:
Cell. 149:1257-1268
Thrombospondin (Thbs) proteins are induced in sites of tissue damage or active remodeling. The endoplasmic reticulum (ER) stress response is also prominently induced with disease where it regulates protein production and resolution of misfolded prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b7055fc34c7186b40c7c622a5779d4
https://doi.org/10.1016/j.cell.2012.03.050
https://doi.org/10.1016/j.cell.2012.03.050
Autor:
Yi Zheng, Jeffrey M. Lynch, Allen J. York, Bastiano Sanna, Marjorie Maillet, Jeffery D. Molkentin
Publikováno v:
Journal of Clinical Investigation. 119:3079-3088
To improve contractile function, the myocardium undergoes hypertrophic growth without myocyte proliferation in response to both pathologic and physiologic stimulation. Various membrane-bound receptors and intermediate signal transduction pathways reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c7a8fd84172c7ffbc1c389cd0ad79a
https://doi.org/10.1172/jci37694
https://doi.org/10.1172/jci37694