Zobrazeno 1 - 10
of 352
pro vyhledávání: '"Jeffrey M Burns"'
Autor:
Eric D Vidoni, Jill K Morris, Amber Watts, Mark Perry, Jon Clutton, Angela Van Sciver, Ashwini S Kamat, Jonathan Mahnken, Suzanne L Hunt, Ryan Townley, Robyn Honea, Ashley R Shaw, David K Johnson, James Vacek, Jeffrey M Burns
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0244893 (2021)
BackgroundOur goal was to investigate the role of physical exercise to protect brain health as we age, including the potential to mitigate Alzheimer's-related pathology. We assessed the effect of 52 weeks of a supervised aerobic exercise program on a
Externí odkaz:
https://doaj.org/article/8316e6981c654075aa13126723f6214c
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208581 (2018)
ObjectivesPhysical activity shows promise for reduced risk of Alzheimer's disease (AD) and protection against cognitive decline among individuals with and without AD. Older adults face many barriers to adoption of physically active lifestyles and peo
Externí odkaz:
https://doaj.org/article/115e522c361d42c98a77e00d87f06807
Autor:
Jason L Rucker, Joan M McDowd, Jonathan D Mahnken, Jeffrey M Burns, Carla H Sabus, Amanda J Britton-Carpenter, Nora B Utech, Patricia M Kluding
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186583 (2017)
BACKGROUND AND PURPOSE:Deficits in the ability to multitask contribute to gait abnormalities and falls in many at-risk populations. However, it is unclear whether older adults with type 2 diabetes mellitus (DM) also demonstrate impairments in multita
Externí odkaz:
https://doaj.org/article/f9b03908383c4762a9e1e79e1b401bf8
Autor:
Jill K Morris, Eric D Vidoni, David K Johnson, Angela Van Sciver, Jonathan D Mahnken, Robyn A Honea, Heather M Wilkins, William M Brooks, Sandra A Billinger, Russell H Swerdlow, Jeffrey M Burns
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0170547 (2017)
BACKGROUND:There is increasing interest in the role of physical exercise as a therapeutic strategy for individuals with Alzheimer's disease (AD). We assessed the effect of 26 weeks (6 months) of a supervised aerobic exercise program on memory, execut
Externí odkaz:
https://doaj.org/article/3f739546853645e3a5052a502f8d4b53
Autor:
Eric D Vidoni, David K Johnson, Jill K Morris, Angela Van Sciver, Colby S Greer, Sandra A Billinger, Joseph E Donnelly, Jeffrey M Burns
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131647 (2015)
Epidemiological studies suggest a dose-response relationship exists between physical activity and cognitive outcomes. However, no direct data from randomized trials exists to support these indirect observations. The purpose of this study was to explo
Externí odkaz:
https://doaj.org/article/fd0019f931e84457a38c2bc92cee4c80
Autor:
Steven E. Arnold, Suzanne Hendrix, Jessie Nicodemus‐Johnson, Newman Knowlton, Victoria J. Williams, Jeffrey M. Burns, Monica Crane, Alison J. McManus, Sanjeev N. Vaishnavi, Zoe Arvanitakis, Judith Neugroschl, Karen Bell, Bianca A. Trombetta, Becky C. Carlyle, Pia Kivisäkk, Hiroko H. Dodge, Rudolph E. Tanzi, Patrick D. Yeramian, Kent Leslie
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 10, Iss 3, Pp n/a-n/a (2024)
Abstract INTRODUCTION Sodium phenylbutyrate and taurursodiol (PB and TURSO) is hypothesized to mitigate endoplasmic reticulum stress and mitochondrial dysfunction, two of many mechanisms implicated in Alzheimer's disease (AD) pathophysiology. METHODS
Externí odkaz:
https://doaj.org/article/094dc11770e44f12a0e5cddf65670bfc
Autor:
Matthew K. Taylor, Jeffrey M. Burns, In-Young Choi, Trent J. Herda, Phil Lee, Aaron N. Smith, Debra K. Sullivan, Russell H. Swerdlow, Heather M. Wilkins
Publikováno v:
Pilot and Feasibility Studies, Vol 10, Iss 1, Pp 1-10 (2024)
Abstract Background Impaired brain bioenergetics is a pathological hallmark of Alzheimer’s disease (AD) and is a compelling target for AD treatment. Patients with AD exhibit dysfunction in the brain creatine (Cr) system, which is integral in mainta
Externí odkaz:
https://doaj.org/article/69cb69366c884bc0acef5ad16e3c9069
Autor:
Robyn A Honea, Carlos Cruchaga, Rodrigo D Perea, Andrew J Saykin, Jeffrey M Burns, Daniel R Weinberger, Alison M Goate, Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e76001 (2013)
There is accumulating evidence that neurotrophins, like brain-derived neurotrophic factor (BDNF), may impact aging and Alzheimer's Disease. However, traditional genetic association studies have not found a clear relationship between BDNF and AD. Our
Externí odkaz:
https://doaj.org/article/f1f7f66bbc4a4d45a9dfa182d1be689a
Autor:
Eric D. Vidoni, Emma Swinford, Kelli Barton, Jaime Perales‐Puchalt, C. Michelle Niedens, Tina Lewandowski, Tiffany Schwasinger‐Schmidt, Jill Peltzer, JoEllen Wurth, Jannette Berkley‐Patton, Ryan A. Townley, W. Todd Moore, Ashley R. Shaw, Mickeal N. Key, Erica Andrade, Melissa Robinson, Susan Sprague, Aiden Bondurant, Debra Brook, Jennifer Freund, Jeffrey M. Burns
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 10, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION Recruitment of sufficient and diverse participants into clinical research for Alzheimer's disease and related dementias remains a formidable challenge. The primary goal of this manuscript is to provide an overview of an approach
Externí odkaz:
https://doaj.org/article/6b0b5f1f571746fc9cce62de30439646
Publikováno v:
Contemporary Clinical Trials Communications, Vol 38, Iss , Pp 101277- (2024)
Objective: This retrospective analysis examined serious adverse events (SAEs) and deaths in U.S. lifestyle clinical trials aimed at enhancing cognitive health in older adults. Methods: Data was gathered from trials completed between January 1, 2000,
Externí odkaz:
https://doaj.org/article/7fbc288009ea4662abb6ef6dfab3692a