Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Jeffrey M, Smith"'
Autor:
Olga Meiri Chaim, Shunichiro Miki, Briana C. Prager, Jianhui Ma, Anthony Y. Jeong, Jacqueline Lara, Nancy K. Tran, Jeffrey M. Smith, Jeremy N. Rich, J. Silvio Gutkind, Shigeki Miyamoto, Frank B. Furnari, Joan Heller Brown
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract In silico interrogation of glioblastoma (GBM) in The Cancer Genome Atlas (TCGA) revealed upregulation of GNA12 (Gα12), encoding the alpha subunit of the heterotrimeric G-protein G12, concomitant with overexpression of multiple G-protein cou
Externí odkaz:
https://doaj.org/article/e419c358a7d24206a72d5cdef498840f
Autor:
Tina Meischel, Svenja Fritzlar, Fernando Villalón-Letelier, Jeffrey M. Smith, Andrew G. Brooks, Patrick C. Reading, Sarah L. Londrigan
Publikováno v:
Pathogens, Vol 12, Iss 4, p 519 (2023)
Ectopic protein overexpression in immortalised cell lines is a commonly used method to screen host factors for their antiviral activity against different viruses. However, the question remains as to what extent such artificial protein overexpression
Externí odkaz:
https://doaj.org/article/e3fc0f0b7607426fa04e535f76ee790e
Autor:
Rebecca L. Brocato, Steven A. Kwilas, Robert K. Kim, Xiankun Zeng, Lucia M. Principe, Jeffrey M. Smith, Jay W. Hooper
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-7 (2021)
Abstract A worldwide effort to counter the COVID-19 pandemic has resulted in hundreds of candidate vaccines moving through various stages of research and development, including several vaccines in phase 1, 2 and 3 clinical trials. A relatively small
Externí odkaz:
https://doaj.org/article/021913bd329840d1928fea1d69b27f9e
Autor:
Joseph W Golden, Xiankun Zeng, Curtis R Cline, Jeffrey M Smith, Sharon P Daye, Brian D Carey, Candace D Blancett, Charles J Shoemaker, Jun Liu, Collin J Fitzpatrick, Christopher P Stefan, Aura R Garrison
Publikováno v:
PLoS Pathogens, Vol 18, Iss 5, p e1010485 (2022)
Crimean-Congo hemorrhagic fever virus (CCHFV) is an important human pathogen. In cell culture, CCHFV is sensed by the cytoplasmic RNA sensor retinoic acid-inducible gene I (RIG-I) molecule and its adaptor molecule mitochondrial antiviral signaling (M
Externí odkaz:
https://doaj.org/article/b3ff2a4d1c1549199b8e015d92eb4bc8
Autor:
Collin J. Fitzpatrick, Rajini R. Mudhasani, Louis A. Altamura, Catherine E. Campbell, Julie P. Tran, Brett F. Beitzel, Aarthi Narayanan, Cynthia L. de la Fuente, Kylene Kehn-Hall, Jeffrey M. Smith, Connie S. Schmaljohn, Aura R. Garrison
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Junín virus (JUNV), a New World arenavirus, is a rodent-borne virus and the causative agent of Argentine hemorrhagic fever. Humans become infected through exposure to rodent host secreta and excreta and the resulting infection can lead to an acute i
Externí odkaz:
https://doaj.org/article/55dd30e924ec4a35818baa6124b887a1
Autor:
Eric M. Mucker, Rebecca L. Brocato, Lucia M. Principe, Robert K. Kim, Xiankun Zeng, Jeffrey M. Smith, Steven A. Kwilas, Sungwon Kim, Helen Horton, Lisa Caproni, Jay W. Hooper
Publikováno v:
Vaccines, Vol 10, Iss 7, p 1104 (2022)
To combat the COVID-19 pandemic, an assortment of vaccines has been developed. Nucleic acid vaccines have the advantage of rapid production, as they only require a viral antigen sequence and can readily be modified to detected viral mutations. Doggyb
Externí odkaz:
https://doaj.org/article/8440ec50247a427abd77aa8aa5e7619a
Autor:
Sara C Johnston, Keersten M Ricks, Alexandra Jay, Jo Lynne Raymond, Franco Rossi, Xiankun Zeng, Jennifer Scruggs, David Dyer, Ondraya Frick, Jeffrey W Koehler, Paul A Kuehnert, Tamara L Clements, Charles J Shoemaker, Susan R Coyne, Korey L Delp, Joshua Moore, Kerry Berrier, Heather Esham, Joshua Shamblin, Willie Sifford, Jimmy Fiallos, Leslie Klosterman, Stephen Stevens, Lauren White, Philip Bowling, Terrence Garcia, Christopher Jensen, Jeanean Ghering, David Nyakiti, Stephanie Bellanca, Brian Kearney, Wendy Giles, Nazira Alli, Fabian Paz, Kristen Akers, Denise Danner, James Barth, Joshua A Johnson, Matthew Durant, Ruth Kim, Jay W Hooper, Jeffrey M Smith, Jeffrey R Kugelman, Brett F Beitzel, Kathleen M Gibson, Margaret L M Pitt, Timothy D Minogue, Aysegul Nalca
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0246366 (2021)
Airborne transmission is predicted to be a prevalent route of human exposure with SARS-CoV-2. Aside from African green monkeys, nonhuman primate models that replicate airborne transmission of SARS-CoV-2 have not been investigated. A comparative evalu
Externí odkaz:
https://doaj.org/article/785181030e4e4293b32c07a9d4631b9b
Autor:
Sandra L. Bixler, Christopher P. Stefan, Alexandra N. Jay, Franco D. Rossi, Keersten M. Ricks, Charles J. Shoemaker, Alicia M. Moreau, Xiankun Zeng, Jay W. Hooper, David N. Dyer, Ondraya M. Frick, Jeffrey W. Koehler, Brian J. Kearney, Nina DiPinto, Jun Liu, Samantha D. Tostenson, Tamara L. Clements, Jeffrey M. Smith, Joshua A. Johnson, Kerry L. Berrier, Heather L. Esham, Korey L. Delp, Susan R. Coyne, Holly A. Bloomfield, Paul A. Kuehnert, Kristen Akers, Kathleen M. Gibson, Timothy D. Minogue, Aysegul Nalca, Margaret L. M. Pitt
Publikováno v:
Viruses, Vol 14, Iss 5, p 1013 (2022)
The emergence of SARS-CoV-2 and the subsequent pandemic has highlighted the need for animal models that faithfully replicate the salient features of COVID-19 disease in humans. These models are necessary for the rapid selection, testing, and evaluati
Externí odkaz:
https://doaj.org/article/b063a423a637420e8040c9f1622ed7cc
Autor:
Sara C. Johnston, Keersten M. Ricks, Ines Lakhal-Naouar, Alexandra Jay, Caroline Subra, Jo Lynne Raymond, Hannah A. D. King, Franco Rossi, Tamara L. Clements, David Fetterer, Samantha Tostenson, Camila Macedo Cincotta, Holly R. Hack, Caitlin Kuklis, Sandrine Soman, Jocelyn King, Kristina K. Peachman, Dohoon Kim, Wei-Hung Chen, Rajeshwer S. Sankhala, Elizabeth J. Martinez, Agnes Hajduczki, William C. Chang, Misook Choe, Paul V. Thomas, Caroline E. Peterson, Alexander Anderson, Isabella Swafford, Jeffrey R. Currier, Dominic Paquin-Proulx, Linda L. Jagodzinski, Gary R. Matyas, Mangala Rao, Gregory D. Gromowski, Sheila A. Peel, Lauren White, Jeffrey M. Smith, Jay W. Hooper, Nelson L. Michael, Kayvon Modjarrad, M. Gordon Joyce, Aysegul Nalca, Diane L. Bolton, Margaret L. M. Pitt
Publikováno v:
Vaccines, Vol 10, Iss 5, p 717 (2022)
The COVID-19 pandemic has had a staggering impact on social, economic, and public health systems worldwide. Vaccine development and mobilization against SARS-CoV-2 (the etiologic agent of COVID-19) has been rapid. However, novel strategies are still
Externí odkaz:
https://doaj.org/article/5098da1acb7d4ede9bde551c18bcc8bd
Autor:
Joseph W. Golden, Curtis R. Cline, Xiankun Zeng, Aura R. Garrison, Brian D. Carey, Eric M. Mucker, Lauren E. White, Joshua D. Shamblin, Rebecca L. Brocato, Jun Liu, April M. Babka, Hypaitia B. Rauch, Jeffrey M. Smith, Bradley S. Hollidge, Collin Fitzpatrick, Catherine V. Badger, Jay W. Hooper
Publikováno v:
JCI Insight, Vol 5, Iss 19 (2020)
The emergence of SARS-CoV-2 has created an international health crisis, and small animal models mirroring SARS-CoV-2 human disease are essential for medical countermeasure (MCM) development. Mice are refractory to SARS-CoV-2 infection owing to low-af
Externí odkaz:
https://doaj.org/article/2c20d6ee5a6a43d886df68b98fd87586