Zobrazeno 1 - 10
of 244
pro vyhledávání: '"Jeffrey M, Peters"'
Autor:
Shigetoshi Yokoyama, Imhoi Koo, Daisuke Aibara, Yuan Tian, Iain A. Murray, Stephanie L. Collins, Denise M. Coslo, Mari Kono, Jeffrey M. Peters, Richard L. Proia, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson
Publikováno v:
Advanced Science, Vol 11, Iss 40, Pp n/a-n/a (2024)
Abstract Sphingolipids play vital roles in metabolism and regulation. Previously, the aryl hydrocarbon receptor (AHR), a ligand‐activated transcription factor, was reported to directly regulate ceramide synthesis genes by binding to their promoters
Externí odkaz:
https://doaj.org/article/a855de1025a445adaa26ec6581764497
Autor:
Robert G. Nichols, Bipin Rimal, Fuhua Hao, Jeffrey M. Peters, Emily R. Davenport, Andrew D. Patterson
Publikováno v:
Environment International, Vol 192, Iss , Pp 109022- (2024)
The organophosphate chlorpyrifos is a commonly used pesticide for fruits and vegetables despite its association with neurotoxicity in humans. While some studies suggest that organophosphates may impact the gut microbiota, no studies to date have inve
Externí odkaz:
https://doaj.org/article/99b50383e8e6472790e6e98410c29910
Autor:
Bokai Zhu, Xiaoyang Zhu, Michael G. Borland, Douglas H. Ralph, Christopher R. Chiaro, Kristopher W. Krausz, James M. Ntambi, Adam B. Glick, Andrew D. Patterson, Gary H. Perdew, Frank J. Gonzalez, Jeffrey M. Peters
Publikováno v:
Biomolecules, Vol 14, Iss 6, p 606 (2024)
Nuclear hormone receptors exist in dynamic equilibrium between transcriptionally active and inactive complexes dependent on interactions with ligands, proteins, and chromatin. The present studies examined the hypothesis that endogenous ligands activa
Externí odkaz:
https://doaj.org/article/231cd6ff406947e89aa731b290f06494
Autor:
Xiaoyang Zhu, Qing Liu, Andrew D. Patterson, Arun K. Sharma, Shantu G. Amin, Samuel M. Cohen, Frank J. Gonzalez, Jeffrey M. Peters
Publikováno v:
Metabolites, Vol 13, Iss 8, p 936 (2023)
Long-term ligand activation of PPARα in mice causes hepatocarcinogenesis through a mechanism that requires functional PPARα. However, hepatocarcinogenesis is diminished in both Ppara-null and PPARA-humanized mice, yet both lines develop age-related
Externí odkaz:
https://doaj.org/article/1049ad43d5d041adbdc3b51a8f7b2f5d
Publikováno v:
Human Genomics, Vol 13, Iss 1, Pp 1-10 (2019)
Abstract The human microbiome is composed of four major areas including intestinal, skin, vaginal, and oral microbiomes, with each area containing unique species and unique functionalities. The human microbiome may be modulated with prebiotics, probi
Externí odkaz:
https://doaj.org/article/2489f8ac5a914535bfe665dc7696d75b
Autor:
Jeffrey M Peters
Publikováno v:
Toxicological Sciences. 190:113-116
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e5e53b28837cb0162dfe6912e930e31
https://doi.org/10.1093/toxsci/kfac107
https://doi.org/10.1093/toxsci/kfac107
PDF - 587K, Supplementary Materials and Methods; Supplementary Figure Legend. Supplementary Fig. 1. The effect of over-expressing and/or ligand activation of PPAR/ on cell cycle progression in MDA-MB-231 and MCF7 cells. Supplementary Fig. 2. The effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b66a0b403ad2617419aae0e1faec49
https://doi.org/10.1158/1535-7163.22499644.v1
https://doi.org/10.1158/1535-7163.22499644.v1
The effect of activation and overexpression of the nuclear receptor PPAR-β/δ in human MDA-MB-231 (estrogen receptor–negative; ER−) and MCF7 (estrogen-receptor-positive; ER+) breast cancer cell lines was examined. Target gene induction by ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249420a330d31a68c985c36ead92e48c
https://doi.org/10.1158/1535-7163.c.6536203
https://doi.org/10.1158/1535-7163.c.6536203
Autor:
Takayuki Koga, Jeffrey M. Peters
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1598-1606
Excessive, chronic alcohol consumption can lead to alcoholic liver disease. The etiology of alcoholic liver disease is multifactorial and is influenced by alterations in gene expression and changes in fatty acid metabolism, oxidative stress, and insu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386daeb0a6713543a75e6dad209dbf0d
https://doi.org/10.1248/bpb.b21-00486
https://doi.org/10.1248/bpb.b21-00486
Autor:
Jonghanne Park, Sang Eun Lee, Jin Hur, Eun Byeol Hong, Jae-Il Choi, Ji-Min Yang, Ju-Young Kim, Young-Chan Kim, Hyun-Jai Cho, Jeffrey M. Peters, Seung-Bum Ryoo, Young Tae Kim, Hyo-Soo Kim
Publikováno v:
Cell Reports, Vol 10, Iss 9, Pp 1614-1625 (2015)
We investigate crosstalk between cancer cells and stromal myeloid cells. We find that Lewis lung carcinoma cells significantly induce PPARβ/δ activity in myeloid cells in vitro and in vivo. Myeloid cell-specific knockout of PPARβ/δ results in imp
Externí odkaz:
https://doaj.org/article/54ff192ba67047f48eb2b24391cc4f82