Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Jeffrey M, Beekman"'
Autor:
Juliet W. Lefferts, Suzanne Kroes, Matthew B. Smith, Paul J. Niemöller, Natascha D. A. Nieuwenhuijze, Heleen N. Sonneveld van Kooten, Cornelis K. van der Ent, Jeffrey M. Beekman, Sam F. B. van Beuningen
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Epithelial ion and fluid transport studies in patient-derived organoids (PDOs) are increasingly being used for preclinical studies, drug development and precision medicine applications. Epithelial fluid transport properties in PDOs can be me
Externí odkaz:
https://doaj.org/article/57f8cce43d4e4914a932dc910bdf96e7
Autor:
Lisa W. Rodenburg, Mieke Metzemaekers, Isabelle S. van der Windt, Shannon M. A. Smits, Loes A. den Hertog-Oosterhoff, Evelien Kruisselbrink, Jesse E. Brunsveld, Sabine Michel, Karin M. de Winter-de Groot, Cornelis K. van der Ent, Ralph Stadhouders, Jeffrey M. Beekman, Gimano D. Amatngalim
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The nasal and bronchial epithelium are unified parts of the respiratory tract that are affected in the monogenic disorder cystic fibrosis (CF). Recent studies have uncovered that nasal and bronchial tissues exhibit intrinsic variability, inc
Externí odkaz:
https://doaj.org/article/a3543cd790b84d62a839330093785ed4
Autor:
Lisa W. Rodenburg, Isabelle S. van der Windt, Henriette H.M. Dreyer, Shannon M.A. Smits, Loes A. den Hertog - Oosterhoff, Ellen M. Aarts, Jeffrey M. Beekman, Gimano D. Amatngalim
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102337- (2023)
Summary: We present a protocol to generate organoids from air-liquid-interface (ALI)-differentiated nasal epithelia. We detail their application as cystic fibrosis (CF) disease model in the cystic fibrosis transmembrane conductance regulator (CFTR)-d
Externí odkaz:
https://doaj.org/article/d6d492fca3cb4a8cb381f693b279a9a2
Autor:
Lidewij W. Rümke, Wouter L. Smit, Ailko Bossink, Gijs J. M. Limonard, Danya Muilwijk, Lenneke E. M. Haas, Chantal Reusken, Sanne van der Wal, Bing J. Thio, Yvonne M. G. van Os, Hendrik Gremmels, Jeffrey M. Beekman, Monique Nijhuis, Annemarie M. J. Wensing, Michiel Heron, Steven F. T. Thijsen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Cellular immune responses are of pivotal importance to understand SARS-CoV-2 pathogenicity. Using an enzyme-linked immunosorbent spot (ELISpot) interferon-γ release assay with wild-type spike, membrane and nucleocapsid peptide pools, we longitudinal
Externí odkaz:
https://doaj.org/article/8c593a6ee121461abf9012f213790a7e
Autor:
Juliet W. Lefferts, Marlou C. Bierlaagh, Suzanne Kroes, Natascha D. A. Nieuwenhuijze, Heleen N. Sonneveld van Kooten, Paul J. Niemöller, Tibo F. Verburg, Hettie M. Janssens, Danya Muilwijk, Sam F. B. van Beuningen, Cornelis K. van der Ent, Jeffrey M. Beekman
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14539 (2023)
Cystic fibrosis (CF) is caused by mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene. The combination of the CFTR modulators elexacaftor, tezacaftor, and ivacaftor (ETI) enables the effective rescue of CFTR function in p
Externí odkaz:
https://doaj.org/article/13b60876dda04c7baf1e4694330863a6
Autor:
Sacha Spelier, Eyleen de Poel, Georgia N. Ithakisiou, Sylvia W.F. Suen, Marne C. Hagemeijer, Danya Muilwijk, Annelotte M. Vonk, Jesse E. Brunsveld, Evelien Kruisselbrink, Cornelis K. van der Ent, Jeffrey M. Beekman
Publikováno v:
ERJ Open Research, Vol 9, Iss 1 (2023)
Background Cystic fibrosis (CF) is a rare hereditary disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Recent therapies enable effective restoration of CFTR function of the most common F508del CFTR mu
Externí odkaz:
https://doaj.org/article/b2fb8a6f7608451d90c0f47932df4a5b
Autor:
Henriette H. M. Dreyer, Eleonora Sofie van Tuyll van Serooskerken, Lisa W. Rodenburg, Arnold J. N. Bittermann, Hubertus G. M. Arets, Ellen M. B. P. Reuling, Johannes W. Verweij, Eric G. Haarman, David C. van der Zee, Stefaan H. A. J. Tytgat, Cornelis K. van der Ent, Jeffrey M. Beekman, Gimano D. Amatngalim, Maud Y. A. Lindeboom
Publikováno v:
Children, Vol 10, Iss 6, p 1020 (2023)
Esophageal atresia (EA) is a rare birth defect in which respiratory tract disorders are a major cause of morbidity. It remains unclear whether respiratory tract disorders are in part caused by alterations in airway epithelial cell functions such as t
Externí odkaz:
https://doaj.org/article/49357c20bf05479cb1c93c1c52b71d08
Autor:
Peter van Mourik, Sabine Michel, Annelotte M. Vonk, Jeffrey M. Beekman, Cornelis K. van der Ent, on behalf of the HIT-CF consortium
Publikováno v:
Translational Medicine Communications, Vol 5, Iss 1, Pp 1-8 (2020)
Abstract Background Cystic fibrosis is a rare recessive monogenic disease caused by loss-of-function mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. Recently developed CFTR-modulators (i.e. drugs that rescue CFTR-fun
Externí odkaz:
https://doaj.org/article/97619aed8c814abdb648904ea175743d
Autor:
Eyleen de Poel, Sacha Spelier, Ricardo Korporaal, Ka Wai Lai, Sylvia F. Boj, Katja Conrath, Cornelis K. van der Ent, Jeffrey M. Beekman
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Cystic fibrosis transmembrane conductance regulator (CFTR) modulators have transformed the treatment of cystic fibrosis (CF) by targeting the basis of the disease. In particular, treatment regimen consisting of multiple compounds with complementary m
Externí odkaz:
https://doaj.org/article/c3728af76f74411abfc3fd345775fa10
Autor:
Lisa W. Rodenburg, Livia Delpiano, Violeta Railean, Raquel Centeio, Madalena C. Pinto, Shannon M. A. Smits, Isabelle S. van der Windt, Casper F. J. van Hugten, Sam F. B. van Beuningen, Remco N. P. Rodenburg, Cornelis K. van der Ent, Margarida D. Amaral, Karl Kunzelmann, Michael A. Gray, Jeffrey M. Beekman, Gimano D. Amatngalim
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12657 (2022)
Individuals with cystic fibrosis (CF) suffer from severe respiratory disease due to a genetic defect in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which impairs airway epithelial ion and fluid secretion. New CFTR modulators
Externí odkaz:
https://doaj.org/article/650127a7a0fd43c7b551f63e9bde7b4c