Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jeffrey Lifson"'
Autor:
Justin Harper, Nicolas Huot, Luca Micci, Gregory Tharp, Colin King, Philippe Rascle, Neeta Shenvi, Hong Wang, Cristin Galardi, Amit A. Upadhyay, Francois Villinger, Jeffrey Lifson, Guido Silvestri, Kirk Easley, Beatrice Jacquelin, Steven Bosinger, Michaela Müller-Trutwin, Mirko Paiardini
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Infection of African green monkeys with SIV is associated with reduced pathogenicity. Here the authors explore the requirement of differentiated NK cell populations in a pathogenic Rhesus macaque model of SIV infection and show administration of IL-2
Externí odkaz:
https://doaj.org/article/c2ab2bb398384c18b3ef628de01ccc2b
Autor:
Hannah J. Barbian, Raven Jackson-Jewett, Corrine S. Brown, Frederic Bibollet-Ruche, Gerald H. Learn, Timothy Decker, Edward F. Kreider, Yingying Li, Thomas N. Denny, Paul M. Sharp, George M. Shaw, Jeffrey Lifson, Edward P. Acosta, Michael S. Saag, Katharine J. Bar, Beatrice H. Hahn
Publikováno v:
Retrovirology, Vol 14, Iss 1, Pp 1-9 (2017)
Abstract Background Simian immunodeficiency virus of chimpanzees (SIVcpz), the progenitor of human immunodeficiency virus type 1 (HIV-1), is associated with increased mortality and AIDS-like immunopathology in wild-living chimpanzees (Pan troglodytes
Externí odkaz:
https://doaj.org/article/bf0abb6d568143e1b7703f0c76b02a89
Autor:
Andy A Patamawenu, Nathaniel E Wright, Tulley Shofner, Sean Evans, Maura M Manion, Nicole Doria-Rose, Stephen A Migueles, Daniel Mendoza, Bennett Peterson, Christopher Wilhelm, Julia Rood, Amy Berkley, Nancy A Cogliano, C Jason Liang, Kiki Tesselaar, Frank Miedema, Julian Bess, Jeffrey Lifson, Mark Connors
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0225806 (2019)
Plasmacytoid dendritic cells (PDCs) and their production of interferon-alpha (IFN-α) are believed to play an important role in human immunodeficiency virus, type I (HIV-1) pathogenesis. PDCs produce IFN-α and other proinflammatory cytokines through
Externí odkaz:
https://doaj.org/article/ecd0590a55034ee3a06233212ad50e44
Autor:
Krystelle Nganou-Makamdop, James M Billingsley, Zachary Yaffe, Gregory O'Connor, Gregory K Tharp, Amy Ransier, Farida Laboune, Rodrigo Matus-Nicodemos, Andrea Lerner, Lavina Gharu, Jennifer M Robertson, Mandy L Ford, Martin Schlapschy, Nadine Kuhn, Alexandra Lensch, Jeffrey Lifson, Martha Nason, Arne Skerra, Gideon Schreiber, Steven E Bosinger, Daniel C Douek
Publikováno v:
PLoS Pathogens, Vol 14, Iss 8, p e1007246 (2018)
Chronic activation of the immune system in HIV infection is one of the strongest predictors of morbidity and mortality. As such, approaches that reduce immune activation have received considerable interest. Previously, we demonstrated that administra
Externí odkaz:
https://doaj.org/article/222e9d607de04416ad02ccb59781e2f1
Autor:
Susan V Westmoreland, A Peter Converse, Kasia Hrecka, Mollie Hurley, Heather Knight, Michael Piatak, Jeffrey Lifson, Keith G Mansfield, Jacek Skowronski, Ronald C Desrosiers
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84463 (2014)
Analysis of rhesus macaques infected with a vpx deletion mutant virus of simian immunodeficiency virus mac239 (SIVΔvpx) demonstrates that Vpx is essential for efficient monocyte/macrophage infection in vivo but is not necessary for development of AI
Externí odkaz:
https://doaj.org/article/7d79461adfa943c09a703f3e6947b021
Autor:
Ma Somsouk, Richard M Dunham, Michelle Cohen, Rebecca Albright, Mohamed Abdel-Mohsen, Teri Liegler, Jeffrey Lifson, Michael Piatak, Robert Gorelick, Yong Huang, Yuaner Wu, Priscilla Y Hsue, Jeffrey N Martin, Steven G Deeks, Joseph M McCune, Peter W Hunt
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e116306 (2014)
The anti-inflammatory agent, mesalamine (5-aminosalicylic acid) has been shown to decrease mucosal inflammation in ulcerative colitis. The effect of mesalamine in HIV-infected individuals, who exhibit abnormal mucosal immune activation and microbial
Externí odkaz:
https://doaj.org/article/df60e9cf8f774c4a8d26c8097c573521
Autor:
Jacob D Estes, Levelle D Harris, Nichole R Klatt, Brian Tabb, Stefania Pittaluga, Mirko Paiardini, G Robin Barclay, Jeremy Smedley, Rhonda Pung, Kenneth M Oliveira, Vanessa M Hirsch, Guido Silvestri, Daniel C Douek, Christopher J Miller, Ashley T Haase, Jeffrey Lifson, Jason M Brenchley
Publikováno v:
PLoS Pathogens, Vol 6, Iss 8, p e1001052 (2010)
The chronic phase of HIV infection is marked by pathological activation of the immune system, the extent of which better predicts disease progression than either plasma viral load or CD4(+) T cell count. Recently, translocation of microbial products
Externí odkaz:
https://doaj.org/article/b5191db7f6d542828d9bd9b2ceac4d03
Autor:
Rachel Lubong Sabado, Daniel G Kavanagh, Daniel E Kaufmann, Karlhans Fru, Ethan Babcock, Eric Rosenberg, Bruce Walker, Jeffrey Lifson, Nina Bhardwaj, Marie Larsson
Publikováno v:
PLoS ONE, Vol 4, Iss 1, p e4256 (2009)
The requirements for priming of HIV-specific T cell responses initially seen in infected individuals remain to be defined. Activation of T cell responses in lymph nodes requires cell-cell contact between T cells and DCs, which can give concurrent act
Externí odkaz:
https://doaj.org/article/3027ea93603042d5860ae73c789b289c
Autor:
Cecilia Morgan, Marta Marthas, Christopher Miller, Ann Duerr, Cecilia Cheng-Mayer, Ronald Desrosiers, Jorge Flores, Nancy Haigwood, Shiu-Lok Hu, R Paul Johnson, Jeffrey Lifson, David Montefiori, John Moore, Marjorie Robert-Guroff, Harriet Robinson, Steven Self, Lawrence Corey
Publikováno v:
PLoS Medicine, Vol 5, Iss 8, p e173 (2008)
Externí odkaz:
https://doaj.org/article/b8628b9f5c11487aba93758d6c7da055
Autor:
Meaghan Hancock, Scott Hansen, Daniel Malouli, Emily Marshall, Collette Hughes, Kurt T. Randall, David Morrow, Julia Ford, Roxanne Gilbride, Andrea Selseth, Renee Espinosa Trethewy, Lindsey Bishop, Kelli Oswald, Rebecca Shoemaker, Brian Berkemeier, William Bosche, Michael Hull, Michael Nekorchuk, Kathleen Busman-Sahay, Jacob Estes, Michael Axthelm, Jeremy Smedley, Danica Shao, Paul Edlefsen, Jeffrey Lifson, Klaus Fruh, Jay Nelson, Louis J Picker
Publikováno v:
The Journal of Immunology. 208:64.18-64.18
Strain 68-1 rhesus cytomegalovirus (RhCMV) vectors expressing simian immunodeficiency virus (SIV) antigens demonstrate a vaccine efficacy where 50–60% of vaccinated rhesus macaques are protected from SIV challenge. Intriguingly, RhCMV/SIV vectors e