High-Throughput Screen Identifying the Thiosemicarbazone NSC319726 Compound as a Potent Antimicrobial Lead Against Resistant Strains of Escherichia coli

Autor: Carmen Sadaka, Peter Damborg, Jeffrey L. Watts

Publikováno v: Biomolecules, Vol 8, Iss 4, p 166 (2018)

Antibiotic discovery is vital when considering the increasing antimicrobial resistance threat. The aim of this work was to provide a high-throughput screen (HTS) assay using multidrug-resistant Escherichia coli strains to enable further research into

Externí odkaz: https://doaj.org/article/170a9cfaa0724c38ba35b4ca417713f5

In Vitro ADME Properties of Two Novel Antimicrobial Peptoid-Based Compounds as Potential Agents against Canine Pyoderma

Autor: Ines Greco, Bernard D. Hummel, Jaspreet Vasir, Jeffrey L. Watts, Jason Koch, Johannes E. Hansen, Hanne Mørck Nielsen, Peter Damborg, Paul R. Hansen

Publikováno v: Molecules, Vol 23, Iss 3, p 630 (2018)

Antimicrobial peptides (AMPs) hold promise as the next generation of antimicrobial agents, but often suffer from rapid degradation in vivo. Modifying AMPs with non-proteinogenic residues such as peptoids (oligomers of N-alkylglycines) provides the po

Externí odkaz: https://doaj.org/article/64a07e1c773342c589278a9e685829a6

Questions associated with the development of novel drugs intended for the treatment of bacterial infections in veterinary species

Autor: Jeffrey M. Gilbert, Jeffrey L. Watts, Marilyn N. Martinez

Publikováno v: The Veterinary Journal. 248:79-85

The emergence of multi-drug resistant bacteria has limited therapeutic options for the treatment of bacterial diseases in both human and veterinary medicine. This has resulted in an urgent need for novel agents to treat infectious diseases. Veterinar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aef96052e9c5152f56a0809795c9653
https://doi.org/10.1016/j.tvjl.2019.04.009

Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides

Autor: Paul R. Hansen, Bernard D Hummel, Elin Holmedal, Jeffrey L. Watts, Johan Svenson, Håvard Jenssen, Natalia Molchanova, Joakim Håkansson, Ines Greco

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Greco, I, Molchanova, N, Holmedal, E, Jenssen, H, Hummel, B D, Watts, J L, Håkansson, J, Hansen, P R & Svenson, J 2020, ' Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides ', Scientific Reports, vol. 10, 13206 . https://doi.org/10.1038/s41598-020-69995-9

The use of non-standard toxicity models is a hurdle in the early development of antimicrobial peptides towards clinical applications. Herein we report an extensive in vitro and in vivo toxicity study of a library of 24 peptide-based antimicrobials wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783b769cbed5d1b4894a2bd83e50a34e
https://doi.org/10.1038/s41598-020-69995-9

Evaluation of Veterinary-Specific Interpretive Criteria for Susceptibility Testing of Streptococcus equi Subspecies with Trimethoprim-Sulfamethoxazole and Trimethoprim-Sulfadiazine

Autor: Jeffrey L. Watts, Theo Kanellos, Carmen Sadaka, Luca Guardabassi, Joseph F. Boucher

Publikováno v: Journal of Clinical Microbiology
Sadaka, C, Kanellos, T, Guardabassi, L, Boucher, J & Watts, J L 2017, ' Evaluation of Veterinary-Specific Interpretive Criteria for Susceptibility Testing of Streptococcus equi Subspecies with Trimethoprim-Sulfamethoxazole and Trimethoprim-Sulfadiazine ', Journal of Clinical Microbiology, vol. 55, no. 1, pp. 326-330 . https://doi.org/10.1128/JCM.01610-16

Antimicrobial susceptibility test results for trimethoprim-sulfadiazine with Streptococcus equi subspecies are interpreted based on human data for trimethoprim-sulfamethoxazole. The veterinary-specific data generated in this study support a single br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5740695d71b442cc7d69ad755c8d49e4
http://europepmc.org/articles/PMC5228247