Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Jeffrey L. Dupree"'
Autor:
Mathilde Pruvost, Julia Patzig, Camila Yattah, Ipek Selcen, Marylens Hernandez, Hye-Jin Park, Sarah Moyon, Shibo Liu, Malia S. Morioka, Lindsay Shopland, Osama Al-Dalahmah, Jaroslav Bendl, John F. Fullard, Panos Roussos, James Goldman, Ye He, Jeffrey L. Dupree, Patrizia Casaccia
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112848- (2023)
Summary: Oligodendrocytes are specialized cells that insulate and support axons with their myelin membrane, allowing proper brain function. Here, we identify lamin A/C (LMNA/C) as essential for transcriptional and functional stability of myelinating
Externí odkaz:
https://doaj.org/article/3976a992f3b945e0894a415faea3fb6e
Autor:
Sijia He, Shulan Qiu, Meixia Pan, Juan P. Palavicini, Hu Wang, Xin Li, Anindita Bhattacharjee, Savannah Barannikov, Kevin F. Bieniek, Jeffrey L. Dupree, Xianlin Han
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 7, Pp n/a-n/a (2023)
Abstract Background Despite being a brain disorder, Alzheimer's disease (AD) is often accompanied by peripheral organ dysregulations (e.g., loss of bladder control in late‐stage AD), which highly rely on spinal cord coordination. However, the causa
Externí odkaz:
https://doaj.org/article/0d768f66a1884131945072162b73e1a2
Autor:
Shulan Qiu, Juan Pablo Palavicini, Jianing Wang, Nancy S. Gonzalez, Sijia He, Elizabeth Dustin, Cheng Zou, Lin Ding, Anindita Bhattacharjee, Candice E. Van Skike, Veronica Galvan, Jeffrey L. Dupree, Xianlin Han
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-24 (2021)
Abstract Background Human genetic association studies point to immune response and lipid metabolism, in addition to amyloid-beta (Aβ) and tau, as major pathways in Alzheimer’s disease (AD) etiology. Accumulating evidence suggests that chronic neur
Externí odkaz:
https://doaj.org/article/7968af0cadaf4aba9fed3628e5117c8b
Autor:
Shulan Qiu, Sijia He, Jianing Wang, Hu Wang, Anindita Bhattacharjee, Xin Li, Moawiz Saeed, Jeffrey L. Dupree, Xianlin Han
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10483 (2023)
The interconnection between obesity and central nervous system (CNS) neurological dysfunction has been widely appreciated. Accumulating evidence demonstrates that obesity is a risk factor for CNS neuroinflammation and cognitive impairment. However, t
Externí odkaz:
https://doaj.org/article/d5f6253d88d246d59f08f75eed99eaba
Autor:
Elizabeth Dustin, Edna Suarez-Pozos, Camryn Stotesberry, Shulan Qiu, Juan Pablo Palavicini, Xianlin Han, Jeffrey L. Dupree
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1431 (2023)
3-O-sulfogalactosylceramide, or sulfatide, is a prominent myelin glycosphingolipid reduced in the normal appearing white matter (NAWM) in Multiple Sclerosis (MS), indicating that sulfatide reduction precedes demyelination. Using a mouse model that is
Externí odkaz:
https://doaj.org/article/1d2f112626b94201876886b0f33dc555
Autor:
Jeffrey L. Dupree, Pablo M. Paez, Seema K. Tiwari-Woodruff, Travis T. Denton, Kenneth Hensley, Christina G. Angeliu, Anne I. Boullerne, Sergey Kalinin, Sophia Egge, Veronica T. Cheli, Giancarlo Denaroso, Kelley C. Atkinson, Micah Feri, Douglas L. Feinstein
Publikováno v:
ASN Neuro, Vol 14 (2022)
Although over 20 disease modifying therapies are approved to treat Multiple Sclerosis (MS), these do not increase remyelination of demyelinated axons or mitigate axon damage. Previous studies showed that lanthionine ketenamine ethyl ester (LKE) reduc
Externí odkaz:
https://doaj.org/article/3641087f2b974803ace5d745e6ad5564
Autor:
Elizabeth J. Thomason, Edna Suárez-Pozos, Fatemah S. Afshari, Paul A. Rosenberg, Jeffrey L. Dupree, Babette Fuss
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
The sodium-dependent glutamate transporter GLT-1 (EAAT2, SLC1A2) has been well-described as an important regulator of extracellular glutamate homeostasis in the central nervous system (CNS), a function that is performed mainly through its presence on
Externí odkaz:
https://doaj.org/article/290b92fcbfed4806b157132c79ae06e0
Autor:
Thomas A. Forbes, Evan Z. Goldstein, Jeffrey L. Dupree, Beata Jablonska, Joseph Scafidi, Katrina L. Adams, Yuka Imamura, Kazue Hashimoto-Torii, Vittorio Gallo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Hypoxic brain damage associated with premature birth causes lasting neurological impairments. Here, the authors use environmental enrichment to rescue white matter dysmaturation following hypoxia, while identifying a critical window of intervention a
Externí odkaz:
https://doaj.org/article/c910fba7abca44ef8ee57cdd37894dc5
Autor:
Juan Pablo Palavicini, Lin Ding, Meixia Pan, Shulan Qiu, Hu Wang, Qiang Shen, Jeffrey L. Dupree, Xianlin Han
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 233 (2022)
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive memory loss and a decline in activities of daily life. Ventricular enlargement has been associated with worse performance on global cognitive tests and AD. Our pre
Externí odkaz:
https://doaj.org/article/29437aba45fe45b1a84bc0671716af81
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Postnatal neurodevelopment is profoundly influenced by environmental experiences. Environmental enrichment is a commonly used experimental paradigm that has uncovered numerous examples of experience-dependent plasticity in health and disease. However
Externí odkaz:
https://doaj.org/article/f076371601564d16ad414a390f14d56b