Zobrazeno 1 - 10
of 309
pro vyhledávání: '"Jeffrey L. Brodsky"'
Autor:
Grant J. Daskivich, Jeffrey L. Brodsky
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Proteostasis ensures the proper synthesis, folding, and trafficking of proteins and is required for cellular and organellar homeostasis. This network also oversees protein quality control within the cell and prevents accumulation of aberrant
Externí odkaz:
https://doaj.org/article/44e6354507724197aa1f662570352135
Autor:
Tarun N. Bhatia, Anuj S. Jamenis, Muslim Abbas, Rachel N. Clark, Kristin M. Miner, Manisha N. Chandwani, Roxanne E. Kim, William Hilinski, Lauren A. O'Donnell, Kelvin C. Luk, Yejie Shi, Xiaoming Hu, Jun Chen, Jeffrey L. Brodsky, Rehana K. Leak
Publikováno v:
Neurobiology of Disease, Vol 184, Iss , Pp 106196- (2023)
Reactive microglia are observed with aging and in Lewy body disorders, including within the olfactory bulb of men with Parkinson's disease. However, the functional impact of microglia in these disorders is still debated. Resetting these reactive cell
Externí odkaz:
https://doaj.org/article/9721d7f26b7b4036901bb4feac886942
Autor:
Aidan W. Porter, Diep N. Nguyen, Dennis R. Clayton, Wily G. Ruiz, Stephanie M. Mutchler, Evan C. Ray, Allison L. Marciszyn, Lubika J. Nkashama, Arohan R. Subramanya, Sebastien Gingras, Thomas R. Kleyman, Gerard Apodaca, Linda M. Hendershot, Jeffrey L. Brodsky, Teresa M. Buck
Publikováno v:
JCI Insight, Vol 7, Iss 5 (2022)
Molecular chaperones are responsible for maintaining cellular homeostasis, and one such chaperone, GRP170, is an endoplasmic reticulum (ER) resident that oversees both protein biogenesis and quality control. We previously discovered that GRP170 regul
Externí odkaz:
https://doaj.org/article/2095d64dac0b445d9ccc8fd828f7f516
Publikováno v:
Cell Reports, Vol 36, Iss 12, Pp 109717- (2021)
Summary: To maintain secretory pathway fidelity, misfolded proteins are commonly retained in the endoplasmic reticulum (ER) and selected for ER-associated degradation (ERAD). Soluble misfolded proteins use ER chaperones for retention, but the machine
Externí odkaz:
https://doaj.org/article/9804f08f79df4fb48f318f6e567e993c
Autor:
Sara Sannino, Jeffrey L. Brodsky
Publikováno v:
BMC Biology, Vol 15, Iss 1, Pp 1-20 (2017)
Abstract The efficient production, folding, and secretion of proteins is critical for cancer cell survival. However, cancer cells thrive under stress conditions that damage proteins, so many cancer cells overexpress molecular chaperones that facilita
Externí odkaz:
https://doaj.org/article/3b28fb15549f4abea39d3feb005ab59e
Autor:
Deepa Kumari, Jeffrey L. Brodsky
Publikováno v:
Biomolecules, Vol 11, Iss 8, p 1185 (2021)
All proteins are subject to quality control processes during or soon after their synthesis, and these cellular quality control pathways play critical roles in maintaining homeostasis in the cell and in organism health. Protein quality control is part
Externí odkaz:
https://doaj.org/article/1a96bde198814e6b93502d78c76fff98
Autor:
Lucía F. Zacchi, John C. Dittmar, Michael J. Mihalevic, Annette M. Shewan, Benjamin L. Schulz, Jeffrey L. Brodsky, Kara A. Bernstein
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 9, Pp 1129-1140 (2017)
Dystonia is the third most common movement disorder, but its diagnosis and treatment remain challenging. One of the most severe types of dystonia is early-onset torsion dystonia (EOTD). The best studied and validated EOTD-associated mutation, torsinA
Externí odkaz:
https://doaj.org/article/f7ac7a235cf04b5ba2e8af83825ca350
Autor:
Zhaofeng Ye, Patrick G. Needham, Samuel K. Estabrooks, Susan K. Whitaker, Brandon L. Garcia, Saurav Misra, Jeffrey L. Brodsky, Carlos J. Camacho
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract C-terminus of Hsc/p70-Interacting Protein (CHIP) is a homodimeric E3 ubiquitin ligase. Each CHIP monomer consists of a tetratricopeptide-repeat (TPR), helix-turn-helix (HH), and U-box domain. In contrast to nearly all homodimeric proteins, C
Externí odkaz:
https://doaj.org/article/b2c7a5756fd942c79d8b34c96e08a1e3
Autor:
Samuel Estabrooks, Jeffrey L. Brodsky
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 2, p 452 (2020)
Cystic fibrosis (CF) is the most common lethal inherited disease among Caucasians in North America and a significant portion of Europe. The disease arises from one of many mutations in the gene encoding the cystic fibrosis transmembrane conductance r
Externí odkaz:
https://doaj.org/article/8261ff1e0dbd4ca493c64ad7cdcf8321
Autor:
Anthony Schwacha, William L. Seibel, Jeffrey L. Brodsky, Sandlin Seguin, Matthew L. Bochman, Nicholas Simon
Publikováno v:
Bioscience Reports, Vol 33, Iss 5, p e00072 (2013)
Most currently available small molecule inhibitors of DNA replication lack enzymatic specificity, resulting in deleterious side effects during use in cancer chemotherapy and limited experimental usefulness as mechanistic tools to study DNA replicatio
Externí odkaz:
https://doaj.org/article/1786dfeaa82a41adb9ae5a0d07c60462