Zobrazeno 1 - 10
of 432
pro vyhledávání: '"Jeffrey L. Platt"'
Autor:
Renan B. Sper, Jessica Proctor, Odessa Lascina, Ling Guo, Kathryn Polkoff, Tobias Kaeser, Sean Simpson, Luke Borst, Katherine Gleason, Xia Zhang, Bruce Collins, Yanet Murphy, Jeffrey L. Platt, Jorge A. Piedrahita
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
Mice with severe combined immunodeficiency are commonly used as hosts of human cells. Size, longevity, and physiology, however, limit the extent to which immunodeficient mice can model human systems. To address these limitations, we generated RAG2−
Externí odkaz:
https://doaj.org/article/7a3922f25e6c4f00a302e70e74c3ba8c
Autor:
Ranjeet S. Kalsi, Alina Ostrowska, Adam Olson, Mubina Quader, Melvin Deutsch, Norma J. Arbujas-Silva, Jen Symmonds, Alejandro Soto-Gutierrez, John J. Crowley, Miguel Reyes-Mugica, Giselle Sanchez-Guerrero, Hartmut Jaeschke, Bruce P. Amiot, Marilia Cascalho, Scott L. Nyberg, Jeffrey L. Platt, Edgar N. Tafaleng, Ira J. Fox
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Acute hepatic failure is associated with high morbidity and mortality for which the only definitive therapy is liver transplantation. Some fraction of those who undergo emergency transplantation have been shown to recover native liver function when t
Externí odkaz:
https://doaj.org/article/4a6dde84b6564e42889da8c6dbe04394
Autor:
Mayara Garcia de Mattos Barbosa, Adam R. Lefferts, Daniel Huynh, Hui Liu, Yu Zhang, Beverly Fu, Jenna Barnes, Milagros Samaniego, Richard J. Bram, Raif S. Geha, Ariella Shikanov, Eline T. Luning Prak, Evan A. Farkash, Jeffrey L. Platt, Marilia Cascalho
Publikováno v:
JCI Insight, Vol 6, Iss 17 (2021)
Host genes define the severity of inflammation and immunity but specific loci doing so are unknown. Here we show that TNF receptor superfamily member 13B (TNFRSF13B) variants, which enhance defense against certain pathogens, also control immune-media
Externí odkaz:
https://doaj.org/article/a070c085b731448ba55137aa11437ce9
Autor:
Jeffrey L. Platt, Mayara Garcia de Mattos Barbosa, Daniel Huynh, Adam R. Lefferts, Juhi Katta, Cyra Kharas, Peter Freddolino, Christine M. Bassis, Christiane Wobus, Raif Geha, Richard Bram, Gabriel Nunez, Nobuhiko Kamada, Marilia Cascalho
Publikováno v:
JCI Insight, Vol 6, Iss 14 (2021)
TNFRSF13B encodes the transmembrane activator and CAML interactor (TACI) receptor, which drives plasma cell differentiation. Although TNFRSF13B supports host defense, dominant-negative TNFRSF13B alleles are common in humans and other species and only
Externí odkaz:
https://doaj.org/article/2aff0f4d4cf946c4a166ddace676d083
Autor:
Mayara Garcia de Mattos Barbosa, Hui Liu, Daniel Huynh, Greg Shelley, Evan T. Keller, Brian T. Emmer, Emily Sherman, David Ginsburg, Andrew A. Kennedy, Andrew W. Tai, Christiane Wobus, Carmen Mirabeli, Thomas M. Lanigan, Milagros Samaniego, Wenzhao Meng, Aaron M. Rosenfeld, Eline T. Luning Prak, Jeffrey L. Platt, Marilia Cascalho
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
Abs that neutralize SARS-CoV-2 are thought to provide the most immediate and effective treatment for those severely afflicted by this virus. Because coronavirus potentially diversifies by mutation, broadly neutralizing Abs are especially sought. Here
Externí odkaz:
https://doaj.org/article/198aea9cddb24432ade981042f42b068
Autor:
Marilia Cascalho, Jeffrey L. Platt
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
B cell differentiation and memory are controlled by the transmembrane activator and CAML interactor (TACI), a receptor encoded by TNFRSF13B. TNFRSF13B mutations are frequently found in common variable immunodeficiency (CVID) and in IgA -deficiency; y
Externí odkaz:
https://doaj.org/article/535c3abe2a2a43c7beff4e231f773276
Autor:
Marilia, Cascalho, Jeffrey L, Platt
Publikováno v:
Human Immunology. 84:27-33
Antibodies directed against organ transplants are thought to pose the most vexing hurdle to enduring function and survival of the transplants, particularly organ xenotransplants, and accordingly basic and clinical investigation has focused on elucida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b1c73cd4f48fc65f7a5e25b8dff246
https://doi.org/10.1016/j.humimm.2022.09.006
https://doi.org/10.1016/j.humimm.2022.09.006
Publikováno v:
Journal of Clinical and Translational Science, Vol 5, Pp 21-21 (2021)
ABSTRACT IMPACT: We devised a new method to produce highly potent SARS-CoV2-specific that can be used to treat severely ill patients with Covid-19. OBJECTIVES/GOALS: Neutralizing antibodies against SARS-CoV-2 are thought to offer the most immediate a
Externí odkaz:
https://doaj.org/article/a86326e5bb064ef198a5966ac15f000d
Autor:
Erek Nelson, Fang Jin, Taofic Mounajjed, Yao Jia, Wei Zhou, Raymond D. Hickey, Aaron J. Johnson, Bruce Amiot, Scott L. Nyberg, Randall S. Prather, Adam J. Wood, Anna Spate, Dong Jin Joo, Min Shi, Kevin D. Wells, Anna Minshew, Ellen L. Larson, Joeseph Lillegard, Piero Rinaldo, Anan Abu Rmilah, Eric M. Walters, Jeffrey L. Platt, Melanie C. Bois, Melissa Samuel, Jaime Glorioso, Kristin M. Whitworth, Shennen A. Mao
Publikováno v:
Tissue Engineering Part A. 28:150-160
The mammalian liver's regenerative ability has led researchers to engineer animals as incubators for expansion of human hepatocytes. The expansion properties of human hepatocytes in immunodeficient...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a629f10412d29b240b29ca025b98851
https://doi.org/10.1089/ten.tea.2021.0057
https://doi.org/10.1089/ten.tea.2021.0057
Autor:
Nancy Wilson, Shannon Reese, Lucy Ptak, Fahad Aziz, Sandesh Parajuli, Vadim Jucaud, Shari Denham, Ameet Mishra, Marilia Cascalho, Jeffrey L. Platt, Peiman Hematti, Arjang Djamali
Publikováno v:
Kidney360.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc683bf2fcb0e8e2847034ca88f5dfaf
https://doi.org/10.34067/kid.0000000000000113
https://doi.org/10.34067/kid.0000000000000113