Zobrazeno 1 - 10
of 279
pro vyhledávání: '"Jeffrey L Brodsky"'
Autor:
Nga H Nguyen, Srikant Sarangi, Erin M McChesney, Shaohu Sheng, Jacob D Durrant, Aidan W Porter, Thomas R Kleyman, Zachary W Pitluk, Jeffrey L Brodsky
Publikováno v:
PLoS Genetics, Vol 19, Iss 11, p e1011051 (2023)
Bartter syndrome is a group of rare genetic disorders that compromise kidney function by impairing electrolyte reabsorption. Left untreated, the resulting hyponatremia, hypokalemia, and dehydration can be fatal, and there is currently no cure. Bartte
Externí odkaz:
https://doaj.org/article/ca3e28654917432d9789ab1d62f078b6
Autor:
Sara Sannino, Megan E Yates, Mark E Schurdak, Steffi Oesterreich, Adrian V Lee, Peter Wipf, Jeffrey L Brodsky
Publikováno v:
eLife, Vol 10 (2021)
Molecular chaperones, such as Hsp70, prevent proteotoxicity and maintain homeostasis. This is perhaps most evident in cancer cells, which overexpress Hsp70 and thrive even when harboring high levels of misfolded proteins. To define the response to pr
Externí odkaz:
https://doaj.org/article/28e1a0e451824530985dbf869cbc89c6
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 4, p e1007749 (2020)
The renal outer medullary potassium (ROMK) channel is essential for potassium transport in the kidney, and its dysfunction is associated with a salt-wasting disorder known as Bartter syndrome. Despite its physiological significance, we lack a mechani
Externí odkaz:
https://doaj.org/article/0487c1f81a1847eaa979102ea2265a93
Autor:
Nicolas A Pabon, Yan Xia, Samuel K Estabrooks, Zhaofeng Ye, Amanda K Herbrand, Evelyn Süß, Ricardo M Biondi, Victoria A Assimon, Jason E Gestwicki, Jeffrey L Brodsky, Carlos J Camacho, Ziv Bar-Joseph
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 12, p e1006651 (2018)
An expanded chemical space is essential for improved identification of small molecules for emerging therapeutic targets. However, the identification of targets for novel compounds is biased towards the synthesis of known scaffolds that bind familiar
Externí odkaz:
https://doaj.org/article/34634c75dc7c43d1b7435c229390e398
Autor:
Matthew J Shurtleff, Daniel N Itzhak, Jeffrey A Hussmann, Nicole T Schirle Oakdale, Elizabeth A Costa, Martin Jonikas, Jimena Weibezahn, Katerina D Popova, Calvin H Jan, Pavel Sinitcyn, Shruthi S Vembar, Hilda Hernandez, Jürgen Cox, Alma L Burlingame, Jeffrey L Brodsky, Adam Frost, Georg HH Borner, Jonathan S Weissman
Publikováno v:
eLife, Vol 7 (2018)
The endoplasmic reticulum (ER) supports biosynthesis of proteins with diverse transmembrane domain (TMD) lengths and hydrophobicity. Features in transmembrane domains such as charged residues in ion channels are often functionally important, but coul
Externí odkaz:
https://doaj.org/article/4ca12fd255584f7abfe1d7b19016f4ea
Autor:
W Joon Chung, Jennifer L Goeckeler-Fried, Viktoria Havasi, Annette Chiang, Steven M Rowe, Zackery E Plyler, Jeong S Hong, Marina Mazur, Gary A Piazza, Adam B Keeton, E Lucile White, Lynn Rasmussen, Allan M Weissman, R Aldrin Denny, Jeffrey L Brodsky, Eric J Sorscher
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0163615 (2016)
Small molecules that correct the folding defects and enhance surface localization of the F508del mutation in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) comprise an important therapeutic strategy for cystic fibrosis lung disease. H
Externí odkaz:
https://doaj.org/article/5aa68f888e6b4637be0734ba8a6e6965
Autor:
Christian Adam, Anne Baeurle, Jeffrey L Brodsky, Peter Wipf, David Schrama, Jürgen Christian Becker, Roland Houben
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e92041 (2014)
Merkel Cell Carcinoma (MCC) is a rare and highly aggressive neuroendocrine skin cancer for which no effective treatment is available. MCC represents a human cancer with the best experimental evidence for a causal role of a polyoma virus. Large T anti
Externí odkaz:
https://doaj.org/article/db20a330f6c949fd8d59fef503ded674
Autor:
Ursula Andreo, Liang Guo, Doru V Chirieac, Ana C Tuyama, Emilie Montenont, Jeffrey L Brodsky, Edward A Fisher
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57590 (2013)
Both in humans and animal models, an acute increase in plasma insulin levels, typically following meals, leads to transient depression of hepatic secretion of very low density lipoproteins (VLDL). One contributing mechanism for the decrease in VLDL s
Externí odkaz:
https://doaj.org/article/a6c2c43a04d24deea770a57e280fcd1c
Autor:
Matthew D Neal, Hongpeng Jia, Benjamin Eyer, Misty Good, Christopher J Guerriero, Chhinder P Sodhi, Amin Afrazi, Thomas Prindle, Congrong Ma, Maria Branca, John Ozolek, Jeffrey L Brodsky, Peter Wipf, David J Hackam
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65779 (2013)
Many inflammatory diseases may be linked to pathologically elevated signaling via the receptor for lipopolysaccharide (LPS), toll-like receptor 4 (TLR4). There has thus been great interest in the discovery of TLR4 inhibitors as potential anti-inflamm
Externí odkaz:
https://doaj.org/article/7ac61acca89f407e9b1fd71db80e98bf
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20047 (2011)
Plasmodium falciparum causes the most virulent form of malaria and encodes a large number of molecular chaperones. Because the parasite encounters radically different environments during its lifecycle, many members of this chaperone ensemble may be e
Externí odkaz:
https://doaj.org/article/b12a8692958341f4b44fc4a3fd501b0d