Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Jeffrey L Bennett"'
Autor:
Jeffrey L. Bennett, Sean J. Pittock, Friedemann Paul, Ho Jin Kim, Sarosh R. Irani, Kevin C. O'Connor, Kristina R. Patterson, Michael A. Smith, Michele Gunsior, Nanette Mittereder, William A. Rees, Daniel Cimbora, Bruce A. C. Cree
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 10, Pp 2792-2798 (2024)
Abstract This post hoc analysis of the randomized, placebo‐controlled N‐MOmentum study (NCT02200770) of inebilizumab in neuromyelitis optica spectrum disorder (NMOSD) evaluated relationships between circulating B‐cell subsets and aquaporin‐4
Externí odkaz:
https://doaj.org/article/0428a4d92b3b4cc6b32de98550688c52
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
B cells play a central role in multiple sclerosis (MS) pathology. B and plasma cells may contribute to disease activity through multiple mechanisms: antigen presentation, cytokine secretion, or antibody production. Molecular analyses of B cell popula
Externí odkaz:
https://doaj.org/article/ca16aa9f719b421bb93a18b183dc12f6
Autor:
Sara Samadzadeh, Rafl Adnan, Paulina Berglova, Mahdi Barzegar, Birgit Debrabant, Stine Gundtoft Roikjaer, Michael Levy, Axel Petzold, Jacqueline Palace, Eoin P. Flanagan, Sara Mariotto, Soeren T. Skou, Anne Froelich, Itay Lotan, Silvia Messina, Ruth Geraldes, Susanna Asseyer, Hadas Stiebel-Kalish, Frederike Cosima Oertel, Vahid Shaygannejad, Mohammad Ali Sahraian, Ho Jin Kim, Jeffrey L. Bennett, Chotima Böttcher, Hanna G. Zimmermann, Brian G. Weinshenker, Friedemann Paul, Nasrin Asgari
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Comorbidities in patients with multiple sclerosis (MS) and antibody-mediated diseases of the central nervous system (CNS) including neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein (MOG)-antibody-associated dise
Externí odkaz:
https://doaj.org/article/2b740f34241942d389bbfe03e7b0adef
Autor:
Ho Jin Kim, Orhan Aktas, Kristina R. Patterson, Schaun Korff, Amy Kunchok, Jeffrey L. Bennett, Brian G. Weinshenker, Friedemann Paul, Hans‐Peter Hartung, Daniel Cimbora, Michael A. Smith, Nanette Mittereder, William A. Rees, Dewei She, Bruce A. C. Cree
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 12, Pp 2413-2420 (2023)
Abstract Inebilizumab, a humanized, glycoengineered, IgG1 monoclonal antibody that depletes CD19+ B‐cells, is approved to treat aquaporin 4 (AQP4) IgG‐seropositive neuromyelitis optica spectrum disorder (NMOSD). Inebilizumab is afucosylated and e
Externí odkaz:
https://doaj.org/article/117e79e5e7134a03b6b3f3c65a13a5f5
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27412 (2011)
The pathogenesis of neuromyelitis optica (NMO) involves binding of IgG autoantibodies (NMO-IgG) to aquaporin-4 (AQP4) on astrocytes in the central nervous system (CNS). We studied the in vivo processing in mice of a recombinant monoclonal human NMO-I
Externí odkaz:
https://doaj.org/article/7d217e401d794bab8d10c16013702077
Autor:
Gregory P. Owens, Timothy J. Fellin, Adeline Matschulat, Vanessa Salas, Kristin L. Schaller, Katherine S. Given, Alanna M. Ritchie, Andre Navarro, Kevin Blauth, Ethan G. Hughes, Wendy B. Macklin, Jeffrey L. Bennett
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
B cell clonal expansion and cerebrospinal fluid (CSF) oligoclonal IgG bands are established features of the immune response in multiple sclerosis (MS). Clone-specific recombinant monoclonal IgG1 Abs (rAbs) derived from MS patient CSF plasmablasts bou
Externí odkaz:
https://doaj.org/article/5c9b85e85c2341ef917d380b1f3354df
Autor:
Jeffrey L. Bennett, Kazuo Fujihara, Ho Jin Kim, Romain Marignier, Kevin C. O'Connor, Robert C. Sergott, Anthony Traboulsee, Heinz Wiendl, Jens Wuerfel, Scott S. Zamvil, Veronica G. Anania, Regine Buffels, Thomas Künzel, Annemarie N. Lekkerkerker, Siân Lennon-Chrimes, Sean J. Pittock
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
BackgroundNeuromyelitis optica spectrum disorder (NMOSD) is a rare, autoimmune disease of the central nervous system that produces acute, unpredictable relapses causing cumulative neurological disability. Satralizumab, a humanized, monoclonal recycli
Externí odkaz:
https://doaj.org/article/65073f7848d74c30812b90f40057ec13
Autor:
Jeffrey L. Bennett, Orhan Aktas, William A. Rees, Michael A. Smith, Michele Gunsior, Li Yan, Dewei She, Daniel Cimbora, Sean J. Pittock, Brian G. Weinshenker, Friedemann Paul, Romain Marignier, Dean Wingerchuk, Gary Cutter, Ari Green, Hans-Peter Hartung, Ho Jin Kim, Kazuo Fujihara, Michael Levy, Eliezer Katz, Bruce A.C. Cree
Publikováno v:
EBioMedicine, Vol 86, Iss , Pp 104321- (2022)
Summary: Background: Inebilizumab is an anti-CD19 antibody approved for the treatment of neuromyelitis optica spectrum disorder (NMOSD) in adults with aquaporin-4 autoantibodies. The relationship between B-cell, plasma-cell (PC), and immunoglobulin d
Externí odkaz:
https://doaj.org/article/790df91e946941298837a5937869bc85
Autor:
Joachim Havla, Thivya Pakeerathan, Carolin Schwake, Jeffrey L. Bennett, Ingo Kleiter, Ana Felipe-Rucián, Stephanie C. Joachim, Amelie S. Lotz-Havla, Tania Kümpfel, Markus Krumbholz, Eva M. Wendel, Markus Reindl, Charlotte Thiels, Thomas Lücke, Kerstin Hellwig, Ralf Gold, Kevin Rostasy, Ilya Ayzenberg
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-10 (2021)
Abstract Background To investigate age-related severity, patterns of retinal structural damage, and functional visual recovery in pediatric and adult cohorts of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) optic neuritis (O
Externí odkaz:
https://doaj.org/article/e6273de0a81f4441a89f3e0d94a0bee0
Autor:
Ryan Kammeyer, Christopher Mizenko, Stefan Sillau, Alanna Richie, Gregory Owens, Kavita V. Nair, Enrique Alvarez, Timothy L. Vollmer, Jeffrey L. Bennett, Amanda L. Piquet
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
ObjectiveTo evaluate plasma neurofilament light (NfL) levels in autoimmune neurologic disorders (AINDs) and autoimmune encephalitis (AE).BackgroundEach particular neural autoantibody syndrome has a different clinical phenotype, making one unifying cl
Externí odkaz:
https://doaj.org/article/f8efd766766041778fa324b30b8a31c4