Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jeffrey L, Woodhead"'
Autor:
James J. Beaudoin, Kyunghee Yang, Jeffry Adiwidjaja, Guncha Taneja, Paul B. Watkins, Scott Q. Siler, Brett A. Howell, Jeffrey L. Woodhead
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Inhibition of the canalicular phospholipid floppase multidrug resistance protein 3 (MDR3) has been implicated in cholestatic drug-induced liver injury (DILI), which is clinically characterized by disrupted bile flow and damage to the biliary epitheli
Externí odkaz:
https://doaj.org/article/854fa12f4fac4c6c81044b54a6766df4
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 188(1)
Calcitonin gene-related peptide (CGRP) signaling inhibitors have shown efficacy in both the acute and preventive treatment of migraine. Telcagepant, a first-generation CGRP receptor antagonist, was effective but failed in clinical trials due to hepat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa987be0696be48efef7224cc2a9008d
https://pubmed.ncbi.nlm.nih.gov/35556143
https://pubmed.ncbi.nlm.nih.gov/35556143
Autor:
Jeffrey L Woodhead, Kyunghee eYang, Scott Q Siler, Paul Brent Watkins, Kim L.R. Brouwer, Hugh A Barton, Brett A Howell
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
Inhibition of the bile salt export pump (BSEP) has been linked to incidence of drug-induced liver injury (DILI), presumably by the accumulation of toxic bile acids in the liver. We have previously constructed and validated a model of bile acid dispos
Externí odkaz:
https://doaj.org/article/64259af463dc478a95f0ad84590ccafa
Autor:
Sudin eBhattacharya, Lisl K.M. Shoda, Qiang eZhang, Courtney eWoods, Brett A. Howell, Scott Q. Siler, Jeffrey L. Woodhead, Yuching eYang, Patrick eMcMullen, Paul B. Watkins, Melvin E. Andersen
Publikováno v:
Frontiers in Physiology, Vol 3 (2012)
We provide an overview of computational systems biology approaches as applied to the study of chemical- and drug-induced toxicity. The concept of ‘toxicity pathways’ is described in the context of the 2007 US National Academies of Science report,
Externí odkaz:
https://doaj.org/article/578b7eda103f4784bce6ab2aa88a0665
Autor:
Mathias Wind, Paul B. Watkins, Martina Maurer, Marc Engelhardt, Simon Messner, Anne Schmitt-Hoffmann, Jochen Spickermann, Franziska Paech, Jeffrey L. Woodhead, Anne-Therese Witschi, Brett A. Howell, Scott Q. Siler, Stephan Krähenbühl
Publikováno v:
Clinical and Translational Science. 11:498-505
Elevations of liver enzymes have been observed in clinical trials with BAL30072, a novel antibiotic. In vitro assays have identified potential mechanisms for the observed hepatotoxicity, including electron transport chain (ETC) inhibition and reactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fca62afdc992a3b97a30d486c944b62
https://doi.org/10.1111/cts.12560
https://doi.org/10.1111/cts.12560
Autor:
Scott Q. Siler, Simone H. Stahl, Jeffrey L. Woodhead, Brett A. Howell, Christina Battista, Kyunghee Yang, Jerome T. Mettetal, Paul B. Watkins
Publikováno v:
Clinical Pharmacology and Therapeutics
Elevations in serum bilirubin during drug treatment may indicate global liver dysfunction and a high risk of liver failure. However, drugs also can increase serum bilirubin in the absence of hepatic injury by inhibiting specific enzymes/transporters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba10f5b6f0d3bc33487cda49213c9ef2
https://doi.org/10.1002/cpt.619
https://doi.org/10.1002/cpt.619
Publikováno v:
Pharmaceutical Research
Purpose Autosomal-dominant polycystic kidney disease (ADPKD) is an orphan disease with few current treatment options. The vasopressin V2 receptor antagonist tolvaptan is approved in multiple countries for the treatment of ADPKD, however its use is as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eadb95190e28a387f75c56345d9e195b
https://pubmed.ncbi.nlm.nih.gov/31909447
https://pubmed.ncbi.nlm.nih.gov/31909447
Autor:
Kim L. R. Brouwer, Robert L. St. Claire, Jeffrey L. Woodhead, Paul B. Watkins, Cen Guo, Scott Q. Siler, Kyunghee Yang, Brett A. Howell
Publikováno v:
Journal of Pharmaceutical Sciences. 105:443-459
Sandwich-cultured hepatocytes (SCH) are metabolically competent and have proper localization of basolateral and canalicular transporters with functional bile networks. Therefore, this cellular model is a unique tool that can be used to estimate bilia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88dd0ea887544fd9508a1db790299c21
https://doi.org/10.1016/j.xphs.2015.11.008
https://doi.org/10.1016/j.xphs.2015.11.008
Autor:
Jeffrey L, Woodhead, Franziska, Paech, Martina, Maurer, Marc, Engelhardt, Anne H, Schmitt-Hoffmann, Jochen, Spickermann, Simon, Messner, Mathias, Wind, Anne-Therese, Witschi, Stephan, Krähenbühl, Scott Q, Siler, Paul B, Watkins, Brett A, Howell
Publikováno v:
Clinical and Translational Science
Elevations of liver enzymes have been observed in clinical trials with BAL30072, a novel antibiotic. In vitro assays have identified potential mechanisms for the observed hepatotoxicity, including electron transport chain (ETC) inhibition and reactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ea01777609800b325bb4d15f93d075d
https://pubmed.ncbi.nlm.nih.gov/29877622
https://pubmed.ncbi.nlm.nih.gov/29877622
Autor:
Lisl K.M. Shoda, Paul B. Watkins, Linsey Stiles, Tom N. Grammatopoulos, Jeffrey L. Woodhead, Sharin E. Roth, Kim L. R. Brouwer, Merrie Mosedale, William J. Brock, Susan E. Shoaf, Brett A. Howell, Rachel J. Church, Scott Q. Siler
Publikováno v:
Toxicological Sciences
Tolvaptan is a selective vasopressin V2 receptor antagonist, approved in several countries for the treatment of hyponatremia and autosomal dominant polycystic kidney disease (ADPKD). No liver injury has been observed with tolvaptan treatment in healt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341d1fd1faffb94b8e2734024d28307d
