Non-linear optical imaging of atherosclerotic plaques in the context of SIV and HIV infection prominently detects crystalline cholesterol esters.

Autor: Min Hi Park, Jeffrey L Suhalim, Firas Elmastour, Santu K Singha, Tadashi Imafuku, Ramanathan Venkatnarayan, Anette Christ, Alena Grebe, Sarah A Oppelt, Dmitri Sviridov, Michael Bukrinsky, Eicke Latz, Eric O Potma, Michael L Fitzgerald

Publikováno v: PLoS ONE, Vol 16, Iss 5, p e0251599 (2021)

Chronic HIV infection may exacerbate atherosclerotic vascular disease, which at advanced stages presents as necrotic plaques rich in crystalline cholesterol. Such lesions can catastrophically rupture precipitating myocardial infarct and stroke, now i

Externí odkaz: https://doaj.org/article/7d927e6dabde409bb967982a5d3e7a01

Correction: Spaceflight Activates Lipotoxic Pathways in Mouse Liver.

Autor: Karen R Jonscher, Alba Alfonso-Garcia, Jeffrey L Suhalim, David J Orlicky, Eric O Potma, Virginia L Ferguson, Mary L Bouxsein, Ted A Bateman, Louis S Stodieck, Moshe Levi, Jacob E Friedman, Daila S Gridley, Michael J Pecaut

Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0155282 (2016)

[This corrects the article DOI: 10.1371/journal.pone.0152877.].

Externí odkaz: https://doaj.org/article/e2040aea9eb74ed2a5b51b4b2ca68c78

Non-linear optical imaging of atherosclerotic plaques in the context of SIV and HIV infection prominently detects crystalline cholesterol esters

Autor: Anette Christ, Michael L. Fitzgerald, Sarah A. Oppelt, Firas Elmastour, Eicke Latz, Tadashi Imafuku, Min Hi Park, Santu K. Singha, Jeffrey L. Suhalim, Dmitri Sviridov, Alena Grebe, Eric O. Potma, Ramanathan Venkatnarayan, Michael Bukrinsky

Publikováno v: PloS one, vol 16, iss 5
PLoS ONE, Vol 16, Iss 5, p e0251599 (2021)
PLoS ONE

Chronic HIV infection may exacerbate atherosclerotic vascular disease, which at advanced stages presents as necrotic plaques rich in crystalline cholesterol. Such lesions can catastrophically rupture precipitating myocardial infarct and stroke, now i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e625f0dbb2894b02d28f3d64d5e34c43
https://escholarship.org/uc/item/0wc0g1v7

Spaceflight Activates Lipotoxic Pathways in Mouse Liver

Autor: Moshe Levi, Jacob E. Friedman, Jeffrey L. Suhalim, Michael J. Pecaut, Virginia L. Ferguson, David J. Orlicky, Karen R. Jonscher, Ted A. Bateman, Eric O. Potma, Mary L. Bouxsein, Louis S. Stodieck, Alba Alfonso-Garcia, Daila S. Gridley

Publikováno v: PLoS ONE, Vol 11, Iss 4, p e0152877 (2016)
PloS one, vol 11, iss 4
PLoS ONE

Spaceflight affects numerous organ systems in the body, leading to metabolic dysfunction that may have long-term consequences. Microgravity-induced alterations in liver metabolism, particularly with respect to lipids, remain largely unexplored. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb47a63bb9596a19b4832e3fd1f62b6b

Identification of cholesterol crystals in plaques of atherosclerotic mice using hyperspectral CARS imaging

Autor: Eric O. Potma, Makoto Miyazaki, Shinobu Miyazaki-Anzai, Bruce J. Tromberg, Moshe Levi, Jeffrey L. Suhalim, Ryan S. Lim

Publikováno v: Journal of Lipid Research, Vol 52, Iss 12, Pp 2177-2186 (2011)
Lim, RS; Suhalim, JL; Miyazaki-Anzai, S; Miyazaki, M; Levi, M; Potma, EO; et al.(2011). Identification of cholesterol crystals in plaques of atherosclerotic mice using hyperspectral CARS imaging. Journal of Lipid Research, 52(12), 2177-2186. doi: 10.1194/jlr.M018077. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7xs0x3zw

The accumulation of lipids, including cholesterol, in the arterial wall plays a key role in the pathogenesis of atherosclerosis. Although several advances have been made in the detection and imaging of these lipid structures in plaque lesions, their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8e47ac09a172f2a2fb8a59d5a890b6
http://www.sciencedirect.com/science/article/pii/S0022227520408223