Zobrazeno 1 - 10
of 207
pro vyhledávání: '"Jeffrey L, Goldberg"'
Autor:
Bryce Chiang, Kathleen Heng, Kyeongwoo Jang, Roopa Dalal, Yaping Joyce Liao, David Myung, Jeffrey L Goldberg
Publikováno v:
Drug Delivery, Vol 31, Iss 1 (2024)
Purpose Targeted drug delivery to the optic nerve head may be useful in the preclinical study and later clinical management of optic neuropathies, however, there are no FDA-approved drug delivery systems to achieve this. The purpose of this work was
Externí odkaz:
https://doaj.org/article/c5eceb5501e04f5fb96fb6fec131c03d
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110100- (2024)
Summary: Retinal ganglion cell (RGC) differentiation is tightly controlled by extrinsic and intrinsic factors. Growth and differentiation factor 15 (GDF-15) promotes RGC differentiation, opposite to GDF-11 which inhibits RGC differentiation, both in
Externí odkaz:
https://doaj.org/article/88ed468deb2a4fad955e3eb4570ea27e
Autor:
Michelle T. Sun, MBBS, PhD, Renee M. Cotton, VMD, Chaow Charoenkijkajorn, MD, Julian Garcia-Sanchez, MD, Roopa Dalal, MSc, Xin Xia, MD, PhD, Jonathan H. Lin, MD, PhD, Kuldev Singh, MD, Jeffrey L. Goldberg, MD, PhD, Wendy W. Liu, MD, PhD
Publikováno v:
Ophthalmology Science, Vol 4, Iss 3, Pp 100448- (2024)
Purpose: Verteporfin is a benzoporphyrin derivative which is Food and Drug Administration-approved for treatment of choroidal neovascularization in conjunction with photodynamic therapy. It has been shown to prevent fibrosis and scar formation in sev
Externí odkaz:
https://doaj.org/article/87aec2eb8c6c44b7af2ff9bbb4e59a9d
Autor:
Jonathan R. Soucy, Erika A. Aguzzi, Julie Cho, Michael James Gilhooley, Casey Keuthan, Ziming Luo, Aboozar Monavarfeshani, Meher A. Saleem, Xue-Wei Wang, Juilette Wohlschlegel, The RReSTORe Consortium, Petr Baranov, Adriana Di Polo, Brad Fortune, Kimberly K. Gokoffski, Jeffrey L. Goldberg, William Guido, Alex L. Kolodkin, Carol A. Mason, Yvonne Ou, Thomas A. Reh, Ahmara G. Ross, Brian C. Samuels, Derek Welsbie, Donald J. Zack, Thomas V. Johnson
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-46 (2023)
Abstract Retinal ganglion cell (RGC) death in glaucoma and other optic neuropathies results in irreversible vision loss due to the mammalian central nervous system’s limited regenerative capacity. RGC repopulation is a promising therapeutic approac
Externí odkaz:
https://doaj.org/article/0496dd9029ef4175a2c853ac2f6e61b3
Autor:
Arthur Brant, MD, Natasha Kolomeyer, MD, Jeffrey L. Goldberg, MD, PhD, Julia Haller, MD, Cecilia S. Lee, MD, MS, Aaron Y. Lee, MD, MSCI, Alice C. Lorch, MD, MPH, Joan W. Miller, MD, Leslie Hyman, PhD, Suzann Pershing, MD, MS
Publikováno v:
Ophthalmology Science, Vol 4, Iss 1, Pp 100352- (2024)
Objective: To describe visual acuity data representation in the American Academy of Ophthalmology Intelligent Research in Sight (IRIS) Registry and present a data-cleaning strategy Design: Reliability and validity study. Participants: Patients with v
Externí odkaz:
https://doaj.org/article/575f34d2c265481885ea00317280c664
Autor:
Mishal Rao, Yu-Kai Huang, Chia-Chun Liu, Chandler Meadows, Hui-Chun Cheng, Mengli Zhou, Yu-Chih Chen, Xin Xia, Jeffrey L. Goldberg, Andrew M. Williams, Takaaki Kuwajima, Kun-Che Chang
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract As part of the central nervous system (CNS), retinal ganglion cells (RGCs) and their axons are the only neurons in the retina that transmit visual signals from the eye to the brain via the optic nerve (ON). Unfortunately, they do not regener
Externí odkaz:
https://doaj.org/article/65c1f36d05de4c6aa38bd2db14f7b436
Autor:
Thomas V. Johnson, MD, PhD, Petr Baranov, MD, PhD, Adriana Di Polo, PhD, Brad Fortune, OD, PhD, Kimberly K. Gokoffski, MD, PhD, Jeffrey L. Goldberg, MD, PhD, William Guido, PhD, Alex L. Kolodkin, PhD, Carol A. Mason, PhD, Yvonne Ou, MD, Thomas A. Reh, PhD, Ahmara G. Ross, MD, PhD, Brian C. Samuels, MD, PhD, Donald J. Zack, MD, PhD
Publikováno v:
Ophthalmology Science, Vol 3, Iss 4, Pp 100390- (2023)
Purpose: The Retinal Ganglion Cell (RGC) Repopulation, Stem Cell Transplantation, and Optic Nerve Regeneration (RReSTORe) consortium was founded in 2021 to help address the numerous scientific and clinical obstacles that impede development of vision-
Externí odkaz:
https://doaj.org/article/97c541baf29f4361882762299e8ef428
Autor:
Takahiko Noro, Sahil H. Shah, Yuqin Yin, Riki Kawaguchi, Satoshi Yokota, Kun-Che Chang, Ankush Madaan, Catalina Sun, Giovanni Coppola, Daniel Geschwind, Larry I. Benowitz, Jeffrey L. Goldberg
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Adult central nervous system (CNS) axons fail to regenerate after injury, and master regulators of the regenerative program remain to be identified. We analyzed the transcriptomes of retinal ganglion cells (RGCs) at 1 and 5 days after optic
Externí odkaz:
https://doaj.org/article/38eab275dbca49d18b7dd652b839091d
Autor:
Jeffrey L. Goldberg, MD, PhD, Gala Beykin, MD, Kellie R. Satterfield, MD, Mariana Nuñez, MD, Byron L. Lam, MD, Thomas A. Albini, MD
Publikováno v:
Ophthalmology Science, Vol 3, Iss 3, Pp 100298- (2023)
Purpose: To assess the safety and efficacy of a ciliary neurotrophic factor (CNTF) intraocular implant on neuroprotection and neuroenhancement in glaucoma. Design: Open-label, prospective, phase I clinical trial. Participants: A total of 11 participa
Externí odkaz:
https://doaj.org/article/fa60a287ea4c44debc2a1ecc822aaf44
Autor:
Yuyan Cheng, Yuqin Yin, Alice Zhang, Alexander M. Bernstein, Riki Kawaguchi, Kun Gao, Kyra Potter, Hui-Ya Gilbert, Yan Ao, Jing Ou, Catherine J. Fricano-Kugler, Jeffrey L. Goldberg, Zhigang He, Clifford J. Woolf, Michael V. Sofroniew, Larry I. Benowitz, Daniel H. Geschwind
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Here the authors couple an integrative genomic analysis with substantial in vitro and in vivo experimental validation, identifying REST as a novel suppressor of a pro-regenerative gene program and CNS axon regeneration in mice.
Externí odkaz:
https://doaj.org/article/df6521e5d58e42ea8efb14302c66060b