Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Jeffrey L, Brown"'
Autor:
Robert Godin, Jeffrey L. Brown, Craig D. Logsdon, Baoan Ji, Thiruvengadam Arumugam, Vijaya Ramachandran, Erik Devereaux, Bin Yang, Meghan Scarpitti, Maureen Mertens Hattersley, Todd T. Moore, Rosa F. Hwang
Purpose: The Hedgehog (Hh) pathway has emerged as an important pathway in multiple tumor types and is thought to be dependent on a paracrine signaling mechanism. The purpose of this study was to determine the role of pancreatic cancer-associated fibr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb7a583bec9f92e0b8be531d643bc5ce
https://doi.org/10.1158/1541-7786.c.6541501
https://doi.org/10.1158/1541-7786.c.6541501
Autor:
Robert Godin, Jeffrey L. Brown, Craig D. Logsdon, Baoan Ji, Thiruvengadam Arumugam, Vijaya Ramachandran, Erik Devereaux, Bin Yang, Meghan Scarpitti, Maureen Mertens Hattersley, Todd T. Moore, Rosa F. Hwang
PDF file - 78K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126ca3e361d7fbc84d15ef558d74cdab
https://doi.org/10.1158/1541-7786.22516819.v1
https://doi.org/10.1158/1541-7786.22516819.v1
Autor:
Meredith A. Morgan, Theodore S. Lawrence, Jonathan Maybaum, Sonya D. Zabludoff, Jeffrey L. Brown, Deborah Morosini, Diane M. Simeone, Linda Hylander-Gans, Joshua D. Parsels, Sankari Arumugarajah, Maria C. Hassan, Lili Zhao, Marisa Gross, Daria M. Tanska, Yushen Qian, Leslie A. Parsels
Purpose: Chk1 inhibitors, such as AZD7762, are in clinical development in combination with cytotoxic agents for the treatment of solid tumors, including pancreatic cancers. To maximize the likelihood of their clinical success, it is essential to opti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d413ee72b358ad1b032e8eeb53cf44e
https://doi.org/10.1158/1078-0432.c.6518984.v1
https://doi.org/10.1158/1078-0432.c.6518984.v1
Autor:
Jamal C. Saeh, Gary Hattersley, Jeffrey L. Brown, Chris P. Miller, Hitisha K. Patel, Dannie Wang, Suqin He, Ziyang Yu
Purpose: Steroidal androgens suppress androgen receptor and estrogen receptor positive (AR/ER+) breast cancer cells and were used to treat breast cancer, eliciting favorable response. The current study evaluates the activity and efficacy of the oral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8553acfc0ab5010517ce79db2807dde3
https://doi.org/10.1158/1078-0432.c.6525342.v1
https://doi.org/10.1158/1078-0432.c.6525342.v1
Autor:
Fiona Garner, Gary Hattersley, Dinesh M. Purandare, Jeffrey L. Brown, Hai Jiang, Nianjun Tao, Heike Arlt, Hitisha K. Patel, Teeru Bihani
Supplementary Table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fccab120142b849f2163b795a443272
https://doi.org/10.1158/1078-0432.22462364
https://doi.org/10.1158/1078-0432.22462364
Autor:
Fiona Garner, Gary Hattersley, Dinesh M. Purandare, Jeffrey L. Brown, Hai Jiang, Nianjun Tao, Heike Arlt, Hitisha K. Patel, Teeru Bihani
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0affc5e557f62615a9ed3d3a8ee7f2
https://doi.org/10.1158/1078-0432.22462370
https://doi.org/10.1158/1078-0432.22462370
Autor:
Patrick A. Zweidler-McKay, Lizhi Zeng, Peter E. Zage, Charles Omer, Kevin Webster, Jeffrey L. Brown, Tao Wang, Ethan Hoffmann, Zhong-Ying Liu, Dave Whitston, Haiyun Wang, Terry MacIntyre, Kenneth Thress
Tropomyosin-related kinases (TrkA, TrkB, and TrkC) are receptor tyrosine kinases that, along with their ligands, the neurotrophins, are involved in neuronal cell growth, development, and survival. The Trk-neurotrophin pathway may also play a role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d65b0cf23fb0cb49c94c32ad39f481c3
https://doi.org/10.1158/1535-7163.c.6532115
https://doi.org/10.1158/1535-7163.c.6532115
Autor:
Patrick A. Zweidler-McKay, Lizhi Zeng, Peter E. Zage, Charles Omer, Kevin Webster, Jeffrey L. Brown, Tao Wang, Ethan Hoffmann, Zhong-Ying Liu, Dave Whitston, Haiyun Wang, Terry MacIntyre, Kenneth Thress
Supplementary Fig. S3 from Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a818a25db130bda28d45da9b7537835
https://doi.org/10.1158/1535-7163.22485878
https://doi.org/10.1158/1535-7163.22485878
Autor:
David C. Blakey, Vahe Bedian, Patricia McCoon, Lourdes Pablo, Brenda McDermott, Steve Emery, Mohammad Tabrizi, Joe Q. Zhou, Shenghua Wen, Corinne Reimer, Jane Kendrew, Maria Pinzon-Ortiz, Z. Alexander Cao, Jeffrey L. Brown
Localized angiopoietin-2 (Ang2) expression has been shown to function as a key regulator of blood vessel remodeling and tumor angiogenesis, making it an attractive candidate for antiangiogenic therapy. A fully human monoclonal antibody (3.19.3) was d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417b159458fb57091d42230f783d8590
https://doi.org/10.1158/1535-7163.c.6531830.v1
https://doi.org/10.1158/1535-7163.c.6531830.v1
Autor:
David C. Blakey, Vahe Bedian, Patricia McCoon, Lourdes Pablo, Brenda McDermott, Steve Emery, Mohammad Tabrizi, Joe Q. Zhou, Shenghua Wen, Corinne Reimer, Jane Kendrew, Maria Pinzon-Ortiz, Z. Alexander Cao, Jeffrey L. Brown
Supplementary Table 1, Figure Legends 1-6 from A Human Monoclonal Anti-ANG2 Antibody Leads to Broad Antitumor Activity in Combination with VEGF Inhibitors and Chemotherapy Agents in Preclinical Models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ca5bcc51643122252eeb7952bfdcbd
https://doi.org/10.1158/1535-7163.22485194
https://doi.org/10.1158/1535-7163.22485194