Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jeffrey K. Tong"'
Autor:
Matthew Campbell, Caroline N. Woodward, Jens Sydor, Alfredo C. Castro, James R. Porter, Margaret A. Read, Kerrie Faia, Kerry White, Martin R. Tremblay, Jill Cushing, Julian Adams, Lin-Chen Yu, Mark L. Behnke, Jennifer Hoyt, Vito J. Palombella, Karen McGovern, Somarajan J. Nair, Jeffrey K. Tong, Margit Hagel, Marta Nevalainen, Louis Grenier, Michael Foley
Publikováno v:
Journal of Medicinal Chemistry. 51:6646-6649
Herein is reported the synthesis of a novel class of hedgehog antagonists derived from cyclopamine. The acid sensitive D-ring of cyclopamine was homologated utilizing a sequence of chemoselective cyclopropanation and stereoselective acid-catalyzed re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d0752adc424ed0f2bb4f871b70a4f4
https://doi.org/10.1021/jm8008508
https://doi.org/10.1021/jm8008508
Autor:
Roger H. Pak, Louis Grenier, Julian Adams, Jeffrey K. Tong, James D. Wright, Janid A. Ali, Courtney Penders, Emmanuel Normant, Jens R. Sydor, Jon S. Patterson, Melissa Pink, Jie Ge, Jebecka Hudak, Marlene Dembski, Yilong Zhang, Jim Sang, Christine S. Pien, Caroline N. Woodward, James R. Porter, Margaret Read, John A. Barrett, David Grayzel, Vito J. Palombella
Publikováno v:
Proceedings of the National Academy of Sciences. 103:17408-17413
Heat shock protein 90 (Hsp90) is an emerging therapeutic target of interest for the treatment of cancer. Its role in protein homeostasis and the selective chaperoning of key signaling proteins in cancer survival and proliferation pathways has made it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f11c8483df52f90a7ab65229a46a8d6
https://doi.org/10.1073/pnas.0608372103
https://doi.org/10.1073/pnas.0608372103
Publikováno v:
Journal of Biological Chemistry. 276:47733-47741
Accessibility of the genome to DNA-binding transcription factors is regulated by proteins that control the acetylation of amino-terminal lysine residues on nucleosomal histones. Specifically, histone deacetylase (HDAC) proteins repress transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e86a0cad09669dcd29d2c3554e1ebf3
https://doi.org/10.1074/jbc.m105590200
https://doi.org/10.1074/jbc.m105590200
Autor:
Finny G. Kuruvilla, Alykhan F. Shamji, Stuart L. Schreiber, James S. Hardwick, Jeffrey K. Tong
Publikováno v:
Proceedings of the National Academy of Sciences. 96:14866-14870
The immunosuppressant rapamycin inhibits Tor1p and Tor2p (target of rapamycin proteins), ultimately resulting in cellular responses characteristic of nutrient deprivation through a mechanism involving translational arrest. We measured the immediate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9df262f955ce5ade2c0ed70a34a421b
https://doi.org/10.1073/pnas.96.26.14866
https://doi.org/10.1073/pnas.96.26.14866
Autor:
Robert E. Kingston, Stuart L. Schreiber, Gavin R. Schnitzler, Jeffrey K. Tong, Christian A. Hassig
Publikováno v:
Nature. 395:917-921
The dynamic assembly and remodelling of eukaryotic chromosomes facilitate fundamental cellular processes such as DNA replication and gene transcription. The repeating unit of eukaryotic chromosomes is the nucleosome core, consisting of DNA wound abou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2a63ae7635e73c75ee4a8be86bab72
https://doi.org/10.1038/27699
https://doi.org/10.1038/27699
Publikováno v:
Chemistry & Biology. 4(11):783-789
Inhibition of the enzyme histone deacetylase by butyrate results in the direct transcriptional upregulation of the cyclin-dependent kinase inhibitor p21/Cip1/WAF1. We discuss a small-molecule-mediated signaling pathway to explain the suspected anti-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74cf132de586d185388cbe2616bb8271
Autor:
Asimina T. Georges, Julian Adams, James R Porter, Janid A. Ali, Emmanuel Normant, Yun Gao, Roger H. Pak, Jie Ge, Vito J. Palombella, Thomas T. Tibbitts, Louis Grenier, Marlene S Dembski, Jeffrey K. Tong, Jon Patterson, Jens Sydor
Publikováno v:
Journal of medicinal chemistry. 49(15)
17-Allylamino-17-demethoxygeldanamycin (17-AAG)1 is a semisynthetic inhibitor of the 90 kDa heat shock protein (Hsp90) currently in clinical trials for the treatment of cancer. However, 17-AAG faces challenging formulation issues due to its poor solu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba0ce3785fbf55bd027b3985ccdd2857
https://pubmed.ncbi.nlm.nih.gov/16854066
https://pubmed.ncbi.nlm.nih.gov/16854066
Here we describe the components of a histone deacetylase (HDAC) complex that we term the CoREST-HDAC complex. CoREST-HDAC is composed of polypeptides distinct from previously characterized HDAC1/2-containing complexes such as the mSin3 and nucleosome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cbfd03aaed16373800e216535690a1b
https://europepmc.org/articles/PMC29278/
https://europepmc.org/articles/PMC29278/
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 97(25)
The trichostatin A (TSA)-sensitive histone deacetylase (HDAC) Rpd3p exists in a complex with Sin3p and Sap30p in yeast that is recruited to target promoters by transcription factors including Ume6p. Sir2p is a TSA-resistant HDAC that mediates yeast s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5e7bdddbd6d1bf68dccd5dd7ec6f6e
https://pubmed.ncbi.nlm.nih.gov/11095743
https://pubmed.ncbi.nlm.nih.gov/11095743
Autor:
Tracey C. Fleischer, Christian A. Hassig, Jeffrey K. Tong, Stuart L. Schreiber, Takashi Owa, Phyllis G. Grable, Donald E. Ayer
Treatment of mammalian cells with small molecule histone deacetylase (HDAC) inhibitors induces changes in the transcription of specific genes. These changes correlate directly with an increase in the acetylation levels of all four core histones in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfddf755528cf14dcd0fe93f3b82c418
https://europepmc.org/articles/PMC19868/
https://europepmc.org/articles/PMC19868/