Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jeffrey K. Rymer"'
Autor:
Emma V. Parkins, Darrin H. Brager, Jeffrey K. Rymer, John M. Burwinkel, Diego Rojas, Durgesh Tiwari, Yueh-Chiang Hu, Christina Gross
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract MicroRNAs are an emerging class of synaptic regulators. These small noncoding RNAs post-transcriptionally regulate gene expression, thereby altering neuronal pathways and shaping cell-to-cell communication. Their ability to rapidly alter gen
Externí odkaz:
https://doaj.org/article/07598c5410004486bbda98f3ddb1749f
Autor:
Stavros A. Maurakis, Julie L. Stoudenmire, Jeffrey K. Rymer, Walter J. Chazin, Cynthia Nau Cornelissen
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Neisseria gonorrhoeae causes the sexually transmitted infection (STI) gonorrhea, which afflicts over 80 million people each year. No vaccine is available to prevent gonorrhea. The pathogen alters the expression and antigenic presentation of
Externí odkaz:
https://doaj.org/article/89b200d910ee43688a4b8283629baaf9
Autor:
Jared Travers, Mark Rochman, Cora E. Miracle, Jeff E. Habel, Michael Brusilovsky, Julie M. Caldwell, Jeffrey K. Rymer, Marc E. Rothenberg
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Interleukin-33 (IL-33) can be released as a cytokine or transported into the nucleus, but the significance of this nuclear shuttling is not fully understood. Here the authors show that chromatin-binding of IL-33 alters, unexpectedly, the activity of
Externí odkaz:
https://doaj.org/article/eabe5c744cb94aef8a004eeb291a50d3
Autor:
Durgesh Tiwari, Darrin H. Brager, Jeffrey K. Rymer, Alexander T. Bunk, Angela R. White, Nada A. Elsayed, Joseph C. Krzeski, Andrew Snider, Lindsay M. Schroeder Carter, Steve C. Danzer, Christina Gross
Publikováno v:
Neurobiology of Disease, Vol 130, Iss , Pp 104508- (2019)
Epilepsy is often associated with altered expression or function of ion channels. One example of such a channelopathy is the reduction of A-type potassium currents in the hippocampal CA1 region. The underlying mechanisms of reduced A-type channel fun
Externí odkaz:
https://doaj.org/article/d5e348b2bd184f4db106a450bdff7c98
Autor:
Alexander T. Bunk, Nada A. Elsayed, Steve C. Danzer, Darrin H. Brager, Jeffrey K. Rymer, Deepak Tiwari, Joseph C. Krzeski, Andrew Snider, Lindsay M. Schroeder Carter, Angela R. White, Christina Gross
Publikováno v:
Neurobiol Dis
Neurobiology of Disease, Vol 130, Iss, Pp 104508-(2019)
Neurobiology of Disease, Vol 130, Iss, Pp 104508-(2019)
Epilepsy is often associated with altered expression or function of ion channels. One example of such a channelopathy is the reduction of A-type potassium currents in the hippocampal CA1 region. The underlying mechanisms of reduced A-type channel fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952dda0d890a085dbdee6c908fb0d001
https://pubmed.ncbi.nlm.nih.gov/31212067
https://pubmed.ncbi.nlm.nih.gov/31212067
Autor:
Amitai D. Mandelbaum, Jesus S. Mora, Giancarlo Costaguta, Timothy M. Miller, Guy Haim, Revital Ravid, Ofer Yizhar, Cristiane de Araújo Martins Moreno, Irit Reichenstein, Tsviya Olender, Nicole M. Bode, Smita Saxena, Karen E. Morrison, Hemali Phatnani, Natali Rivkin, Orla Hardiman, Robert H. Brown, Matthew B. Harms, Kim A. Lennox, Kristel R. van Eijk, Jing Liang, Sandra Diaz-Garcia, A. Nazli Basak, Gilad Beck, Samuel L. Pfaff, John Ravits, Chen Eitan, Thomas Möller, Beáta Tóth, Jan H. Veldink, Eran Yanowski, Sali M.K. Farhan, Pamela J. Shaw, Ammar Al-Chalabi, Iddo Magen, Mark A. Behlke, Leonard H. van den Berg, John Landers, Rivka Levy, Elena Ainbinder, Jeffrey K. Rymer, Eran Hornstein, Christina Gross, Aviad Siany, Mariah L. Hoye
Publikováno v:
Sci Transl Med
Science Translational Medicine, 11(523). American Association for the Advancement of Science
Science Translational Medicine
Science Translational Medicine, 11(523). American Association for the Advancement of Science
Science Translational Medicine
Motor neuron–specific microRNA-218 (miR-218) has recently received attention because of its roles in mouse development. However, miR-218 relevance to human motor neuron disease was not yet explored. Here, we demonstrate by neuropathology that miR-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d030811dc749c7fe7014cc4299036f
https://pubmed.ncbi.nlm.nih.gov/31852800
https://pubmed.ncbi.nlm.nih.gov/31852800
Autor:
Mark Rochman, Jeffrey K. Rymer, Jeff E. Habel, Cora E. Miracle, Jared Travers, Julie M. Caldwell, Michael Brusilovsky, Marc E. Rothenberg
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature Communications
Nature Communications
IL-33 is an epithelium-derived, pro-inflammatory alarmin with enigmatic nuclear localization and chromatin binding. Here we report the functional properties of nuclear IL-33. Overexpression of IL-33 does not alter global gene expression in transduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f74b93d5debd430982cb4a9776915b8
https://doi.org/10.1038/s41467-018-05485-x
https://doi.org/10.1038/s41467-018-05485-x
Autor:
Leah C. Kottyan, Jared Travers, Mark Rochman, Jeffrey K. Rymer, Marc E. Rothenberg, Benjamin P. Davis, Emily M. Stucke, Vladislav A. Litosh, M. Eyad Khorki
Publikováno v:
JCI insight. 1(4)
We recently identified a genome-wide genetic association of eosinophilic esophagitis (EoE) at 2p23 spanning the calpain 14 (CAPN14) gene, yet the causal mechanism has not been elucidated. We now show that recombinant CAPN14 cleaves a calpain-specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a42aabc1b738b7176f8ef619ffe9747
https://pubmed.ncbi.nlm.nih.gov/27158675
https://pubmed.ncbi.nlm.nih.gov/27158675
Autor:
Mary C. Bedard, Bruce J. Aronow, Jeffrey K. Rymer, Mark Rochman, Kiran Kc, Kenneth M. Kaufman, Cora E. Miracle, Jared Travers, Benjamin P. Davis, Julie M. Caldwell, Ting Wen, Marc E. Rothenberg, Joseph D. Sherrill, Nurit P. Azouz
Publikováno v:
The Journal of allergy and clinical immunology. 140(3)
Background A key question in the allergy field is to understand how tissue-specific disease is manifested. Eosinophilic esophagitis (EoE) is an emerging tissue-specific allergic disease with an unclear pathogenesis. Objective Herein we tested the hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba7752e3a796e39b5a24e64bb70b993e
https://pubmed.ncbi.nlm.nih.gov/28104354
https://pubmed.ncbi.nlm.nih.gov/28104354
Autor:
Jeffrey K. Rymer, Melinda Hauser, Fred Naider, Shawn R. Campagna, Allen K. Bourdon, Jeffrey M. Becker
G protein-coupled receptors (GPCRs) are the target of many drugs prescribed for human medicine and are therefore the subject of intense study. It has been recognized that compounds called allosteric modulators can regulate GPCR activity by binding to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67acc9da337ac8e93872c845a343049
https://europepmc.org/articles/PMC4331264/
https://europepmc.org/articles/PMC4331264/
