Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jeffrey K. Marshall"'
Autor:
Madhuresh Sumit, Sepideh Dolatshahi, An-Hsiang Adam Chu, Kaffa Cote, John J. Scarcelli, Jeffrey K. Marshall, Richard J. Cornell, Ron Weiss, Douglas A. Lauffenburger, Bhanu Chandra Mulukutla, Bruno Figueroa, Jr.
Publikováno v:
iScience, Vol 12, Iss , Pp 102-120 (2019)
Summary: N-linked glycosylation affects the potency, safety, immunogenicity, and pharmacokinetic clearance of several therapeutic proteins including monoclonal antibodies. A robust control strategy is needed to dial in appropriate glycosylation profi
Externí odkaz:
https://doaj.org/article/662214cb535c4e7da918d110f8ba8f18
Autor:
Yan Zhang, Aaron M. D’Antona, Jeffrey K. Marshall, Cecilia Cooley, Ryan Jackobek, Weili Duan, Amy Tam, Eric Sousa, Gabrielle Bitzas, Sam Zhang, John J. Scarcelli, Lam Khetemenee, Barbara Tevelev, Himakshi Patel, Kathleen Shields, Amy King, Justin Cohen, Wei Wei, Martha Jackson, Lila Wroblewska, Annette Sievers
Publikováno v:
Biotechnology Progress
Site Specific Integration (SSI) expression systems offer robust means of generating highly productive and stable cell lines for traditional monoclonal antibodies. As complex modalities such as antibody-like molecules comprised of greater than two pep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e13703f5170f6411caa4e59ce4af1d5d
http://europepmc.org/articles/PMC8459265
http://europepmc.org/articles/PMC8459265
Autor:
Yan Zhang, John J. Scarcelli, Amy King, Justin Cohen, Amy Tam, Lila Wroblewska, Annette Sievers, Ryan Jackobek, Cecilia Cooley, Sam Zhang, Himakshi Patel, Gabrielle Bitzas, Lam Khetemenee, Barbara Tevelev, Martha Jackson, Weili Duan, Aaron M. D’Antona, Wei Wei, Eric Sousa, Jeffrey K. Marshall, Kathleen Shields
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b05b86a46409a49f86a7f9893097b2a
https://doi.org/10.1002/btpr.3158/v2/response1
https://doi.org/10.1002/btpr.3158/v2/response1
Autor:
Douglas A. Lauffenburger, Sepideh Dolatshahi, John J. Scarcelli, Richard J. Cornell, Madhuresh Sumit, Jeffrey K. Marshall, Kaffa Cote, Bruno Figueroa, Bhanu Chandra Mulukutla, An-Hsiang Adam Chu, Ron Weiss
Publikováno v:
Elsevier
iScience, Vol 12, Iss, Pp 102-120 (2019)
iScience
iScience, Vol 12, Iss, Pp 102-120 (2019)
iScience
Summary N-linked glycosylation affects the potency, safety, immunogenicity, and pharmacokinetic clearance of several therapeutic proteins including monoclonal antibodies. A robust control strategy is needed to dial in appropriate glycosylation profil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf1be6d01d5d9436abfb977029fb3ff
https://hdl.handle.net/1721.1/125974
https://hdl.handle.net/1721.1/125974
Autor:
Richard J. Cornell, Leonid Gaidukov, Jonathan L. Lyles, Jeffrey K. Marshall, Bruno Figueroa, Bhanu Chandra Mulukutla, Nevin M. Summers, An-Hsiang Adam Chu, Timothy K. Lu, Paul Sakorafas, Michelle M Chang, Ron Weiss, Madhuresh Sumit, John J. Scarcelli, Giyoung Jung, Douglas A. Lauffenburger, Boriana Tzvetkova, Wen Allen Tseng, Kaffa Cote, Sepideh Dolatshahi
Publikováno v:
Nature chemical biology. 15(7)
N-linked glycosylation in monoclonal antibodies (mAbs) is crucial for structural and functional properties of mAb therapeutics, including stability, pharmacokinetics, safety and clinical efficacy. The biopharmaceutical industry currently lacks tools
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6440bb1a9a3a346db7dac04cadc56e3
https://pubmed.ncbi.nlm.nih.gov/31110306
https://pubmed.ncbi.nlm.nih.gov/31110306
Autor:
Douglas A. Lauffenburger, John J. Scarcelli, Jeffrey K. Marshall, Richard J. Cornell, Madhuresh Sumit, Ron Weiss, An-Hsiang Adam Chu, Bruno Figueroa, Bhanu Chandra Mulukutla, Kaffa Cote, Sepideh Dolatshahi
Publikováno v:
SSRN Electronic Journal.
N-linked glycosylation is a post-translational modification that affects potency, safety, immunogenicity and pharmacokinetic clearance of several therapeutic proteins including monoclonal antibodies (mAbs). A robust control strategy is needed to accu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0482955d90d511884ae2ee49cc2b534e
https://doi.org/10.2139/ssrn.3232168
https://doi.org/10.2139/ssrn.3232168
Publikováno v:
Secondary Analysis of Electronic Health Records ISBN: 9783319437408
There are several open access health datasets that promote effective retrospective comparative effectiveness research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83713f42523510e7bacf1fa1514ca5d3
https://doi.org/10.1007/978-3-319-43742-2_2
https://doi.org/10.1007/978-3-319-43742-2_2
Autor:
Khetemenee Lam, Richard J. Cornell, Aaron M. D’Antona, Eliza Llewellyn, Ron Kriz, Jeffrey K. Marshall, Evan R. Mahan, Hongli L. Zhu, Weijun Ma, Bruno Figueroa, Annette Sievers, Xiaotian Zhong, C.M. Francis, Boriana Tzvetkova, Dana DiNino, Amy Tam, William S. Somers, Christopher Lee, Jane Guo, Richard Zollner, John J. Scarcelli, Laura Lin, Kaffa Cote, Caryl L. Meade
Publikováno v:
Biotechnology Progress. 35:e2724
Large-scale transient expression in mammalian cells is a rapid protein production technology often used to shorten overall timelines for biotherapeutics drug discovery. In this study we demonstrate transient expression in a Chinese hamster ovary (CHO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::440fd7837885b71e50f94a85c80fd5f4
https://doi.org/10.1002/btpr.2724
https://doi.org/10.1002/btpr.2724