Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Jeffrey K. Huang"'
Autor:
Jingwen Hu, George S. Melchor, Dimitrios Ladakis, Joan Reger, Hee Won Kim, Kelly A. Chamberlain, Nataliia V. Shults, Helena C. Oft, Victoria N. Smith, Lauren M. Rosko, Erqiu Li, Maryna Baydyuk, Meng-Meng Fu, Pavan Bhargava, Jeffrey K. Huang
Publikováno v:
npj Regenerative Medicine, Vol 9, Iss 1, Pp 1-18 (2024)
Abstract Regulation of myeloid cell activity is critical for successful myelin regeneration (remyelination) in demyelinating diseases, such as multiple sclerosis (MS). Here, we show aromatic alpha-keto acids (AKAs) generated from the amino acid oxida
Externí odkaz:
https://doaj.org/article/2b9465e4fbef4a74a3282cd27dd536a3
Autor:
Reiji Yamazaki, Yasuyuki Osanai, Tom Kouki, Yoshiaki Shinohara, Jeffrey K. Huang, Nobuhiko Ohno
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Lysophosphatidylcholine (LPC)-induced demyelination is a versatile animal model that is frequently used to identify and examine molecular pathways of demyelination and remyelination in the central (CNS) and peripheral nervous system (PNS). H
Externí odkaz:
https://doaj.org/article/172e8f312b4e4b13b21153cfac8c51a6
Autor:
Megan E. Rouillard, Jingwen Hu, Pearl A. Sutter, Hee Won Kim, Jeffrey K. Huang, Stephen J. Crocker
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
HMGB1 is a highly conserved, ubiquitous protein in eukaryotic cells. HMGB1 is normally localized to the nucleus, where it acts as a chromatin associated non-histone binding protein. In contrast, extracellular HMGB1 is an alarmin released by stressed
Externí odkaz:
https://doaj.org/article/a4963e36f09b4cdaba664da72e4c6273
Publikováno v:
Journal of Clinical and Translational Science, Vol 5, Pp 99-99 (2021)
ABSTRACT IMPACT: This study highlights the importance of creatine in developmental myelination and remyelination to investigate whether creatine provides a therapeutic value during a central nervous system (CNS) demyelinating insult with a potential
Externí odkaz:
https://doaj.org/article/b782e9a6b57b447f953dfc8e3209fd85
Publikováno v:
Journal of Clinical and Translational Science, Vol 4, Pp 103-103 (2020)
OBJECTIVES/GOALS: Oligodendrocytes (OL) are glial cells of the central nervous system (CNS) responsible for the energy demanding task of generating myelin sheaths during development and remyelination after demyelinating injury. One metabolite shown t
Externí odkaz:
https://doaj.org/article/73f80c47cb424081b8873aececd5a94d
Autor:
Blake A Creighton, Simone Afriyie, Deepa Ajit, Cristine R Casingal, Kayleigh M Voos, Joan Reger, April M Burch, Eric Dyne, Julia Bay, Jeffrey K Huang, ES Anton, Meng-Meng Fu, Damaris N Lorenzo
Publikováno v:
eLife, Vol 10 (2021)
Variants in the high confident autism spectrum disorder (ASD) gene ANK2 target both ubiquitously expressed 220 kDa ankyrin-B and neurospecific 440 kDa ankyrin-B (AnkB440) isoforms. Previous work showed that knock-in mice expressing an ASD-linked Ank2
Externí odkaz:
https://doaj.org/article/617903977b8c47b6bcec06f59021d6f8
Autor:
Lauren M. Rosko, Tyler Gentile, Victoria N. Smith, Zeeba Manavi, George S. Melchor, Jingwen Hu, Nataliia V. Shults, Chris Albanese, Yichien Lee, Olga Rodriguez, Jeffrey K. Huang
Publikováno v:
The Journal of Neuroscience. 43:1143-1153
Cerebral creatine deficiency syndrome (CCDS) is an inborn error of metabolism characterized by intellectual delays, seizures, and autistic-like behavior. However, the role of endogenously synthesized creatine on CNS development and function remains p
Autor:
Alex P. A. Donovan, Lauren Rosko, Jacob Ellegood, Yushi Redhead, Jeremy B. A. Green, Jason P. Lerch, Jeffrey K. Huang, M. Albert Basson
Publikováno v:
Journal of Anatomy.
Publikováno v:
The FASEB Journal. 36
Publikováno v:
Neurochemistry International. 164:105505