Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Jeffrey K. Harrison"'
Autor:
Avirup Chakraborty, Changlin Yang, Jesse L. Kresak, Aryeh J. Silver, Diana Feier, Guimei Tian, Michael Andrews, Olusegun O. Sobanjo, Ethan D. Hodge, Mia K. Engelbart, Jianping Huang, Jeffrey K. Harrison, Matthew R. Sarkisian, Duane A. Mitchell, Loic P. Deleyrolle
Publikováno v:
Cells, Vol 13, Iss 11, p 938 (2024)
Glioblastoma (GBM) poses a significant challenge in clinical oncology due to its aggressive nature, heterogeneity, and resistance to therapies. Cancer stem cells (CSCs) play a critical role in GBM, particularly in treatment resistance and tumor relap
Externí odkaz:
https://doaj.org/article/da408b0d9d444c89803182abab76b701
Autor:
Gregory P. Takacs, Christian J. Kreiger, Defang Luo, Guimei Tian, Julia S. Garcia, Loic P. Deleyrolle, Duane A. Mitchell, Jeffrey K. Harrison
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
Glioblastoma (GBM) is the most common and malignant primary brain tumor, resulting in poor survival despite aggressive therapies. GBM is characterized in part by a highly heterogeneous and immunosuppressive tumor microenvironment (TME) made up predom
Externí odkaz:
https://doaj.org/article/47046643059040e19628c2136bd39cf5
Autor:
Jescelica Ortiz-Rivera, Alejandro Albors, Yuriy Kucheryavykh, Jeffrey K. Harrison, Lilia Kucheryavykh
Publikováno v:
Brain Sciences, Vol 12, Iss 7, p 893 (2022)
Glioblastoma is the most aggressive brain cancer and is highly infiltrated with cells of myeloid lineage (TIM) that support tumor growth and invasion. Tumor resection is the primary treatment for glioblastoma; however, the activation state of TIM at
Externí odkaz:
https://doaj.org/article/ac6ec36def7a4564a564d214250a0f4e
Autor:
Hannah Anderson, Gregory P. Takacs, Christian Kreiger, Defang Luo, Libin Rong, Jeffrey K. Harrison, Tracy Stepien
Publikováno v:
Journal of Clinical and Translational Science, Vol 6, Pp 32-32 (2022)
OBJECTIVES/GOALS: Evaluate the migration and immune suppressive functions of CCR2+/CX3CR1+ myeloid-derived suppressor cells (MDSCs). Integrate experimental data and biologically relevant mathematical models of infiltrating MDSCs in the context of gli
Externí odkaz:
https://doaj.org/article/281f2bbb7bb64c88bfb336435fed2c20
Autor:
Gregory P. Takacs, Hannah Anderson, Christian Kreiger, Defang Luo, Libin Rong, Tracy Stepien, Jeffrey K. Harrison
Publikováno v:
Journal of Clinical and Translational Science, Vol 5, Pp 20-20 (2021)
ABSTRACT IMPACT: Predicting therapeutic responses in GBM. OBJECTIVES/GOALS: The goal of this team approach is to integrate mathematical models of glioblastoma (GBM) infiltrating myeloid cells that contribute to the immunosuppressive phenotype in glio
Externí odkaz:
https://doaj.org/article/89e93bdd33a04f6ba6ff9bfcf34d7a9c
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 8 (2014)
Chemokines are crucial autocrine and paracrine players in tumor development. In particular, CXCL12, through its receptors CXCR4 and CXCR7, affects tumor progression by controlling cancer cell survival, proliferation and migration, and, indirectly, vi
Externí odkaz:
https://doaj.org/article/0ab2abd99c234ef5adac352e9ce5ab13
Autor:
Hannah G. Anderson, Gregory P. Takacs, Duane C. Harris, Yang Kuang, Jeffrey K. Harrison, Tracy L. Stepien
Publikováno v:
bioRxiv
Glioblastoma (GBM) is an aggressive primary brain cancer that currently has minimally effective treatments. Like other cancers, immunosuppression by the PD-L1-PD-1 immune checkpoint complex is a prominent axis by which glioma cells evade the immune s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb6a323a45ea6c9b18ea1a12b0f033d
https://doi.org/10.1101/2023.05.15.540846
https://doi.org/10.1101/2023.05.15.540846
Autor:
Gregory P. Takacs, Christian J. Kreiger, Defang Luo, Guimei Tian, Julia S. Garcia, Loic P. Deleyrolle, Duane A. Mitchell, Jeffrey K. Harrison
Glioblastoma (GBM) is the most common and malignant primary brain tumor, resulting in poor survival despite aggressive therapies. GBM is characterized in part by a highly heterogeneous and immunosuppressive tumor microenvironment (TME) made up predom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c5774b9090e04e5c4c6f48c40e0ef39
https://doi.org/10.1101/2022.07.08.499173
https://doi.org/10.1101/2022.07.08.499173
Autor:
Thomas J. Schall, Joseph Flores-Toro, Rakesh K. Jain, Matthew R. Sarkisian, James Campbell, Jeffrey K. Harrison, Meenal Datta, Adithya Gopinath, Rajinder Singh, Israel F. Charo, Duane Mitchell, Defang Luo
Publikováno v:
Proc Natl Acad Sci U S A
Immunotherapy directed at the PD-L1/PD-1 axis has produced treatment advances in various human cancers. Unfortunately, progress has not extended to glioblastoma (GBM), with phase III clinical trials assessing anti-PD-1 monotherapy failing to show eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997bdf6e35a00f3a51d05f087f953dd5
https://doi.org/10.1073/pnas.1910856117
https://doi.org/10.1073/pnas.1910856117
Autor:
Michael Lim, Loic P. Deleyrolle, David A. Reardon, Farhad Dastmalchi, Maryam Rahman, Aida Karachi, Mark R. Gilbert, Duane Mitchell, Joseph Flores-Toro, W. Gregory Sawyer, Scott Lindhorst, Jeffrey K. Harrison
Publikováno v:
Neuro Oncol
In oncology, “immunotherapy” is a broad term encompassing multiple means of utilizing the patient’s immune system to combat malignancy. Prominent among these are immune checkpoint inhibitors, cellular therapies including chimeric antigen recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da9b9387fc64c4fd636b96919524f241
https://europepmc.org/articles/PMC7523444/
https://europepmc.org/articles/PMC7523444/