Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo study.

Autor: Jeffrey K Lee, Ricki Bettencourt, David Brenner, Thuy-Anh Le, Elizabeth Barrett-Connor, Rohit Loomba

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e34218 (2012)

Interleukin-6 (IL-6) may have a protective role in acute liver disease but a detrimental effect in chronic liver disease. It is unknown whether IL-6 is associated with risk of liver-related mortality in humans.To determine if IL-6 is associated with

Externí odkaz: https://doaj.org/article/371e1603ce4a47369a905b79c6486825

Mutation rates of TGFBR2 and ACVR2 coding microsatellites in human cells with defective DNA mismatch repair.

Autor: Heekyung Chung, Dennis J Young, Claudia G Lopez, Thuy-Anh T Le, Jeffrey K Lee, Deena Ream-Robinson, Sherry C Huang, John M Carethers

Publikováno v: PLoS ONE, Vol 3, Iss 10, p e3463 (2008)

Microsatellite instability promotes colonic tumorigenesis through generating frameshift mutations at coding microsatellites of tumor suppressor genes, such as TGFBR2 and ACVR2. As a consequence, signaling through these TGFbeta family receptors is abr

Externí odkaz: https://doaj.org/article/27f6e1c85a4d4529b5e913814679c85f

Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations

Autor: Minta Thomas, Yu-Ru Su, Elisabeth A. Rosenthal, Lori C. Sakoda, Stephanie L. Schmit, Maria N. Timofeeva, Zhishan Chen, Ceres Fernandez-Rozadilla, Philip J. Law, Neil Murphy, Robert Carreras-Torres, Virginia Diez-Obrero, Franzel J. B. van Duijnhoven, Shangqing Jiang, Aesun Shin, Alicja Wolk, Amanda I. Phipps, Andrea Burnett-Hartman, Andrea Gsur, Andrew T. Chan, Ann G. Zauber, Anna H. Wu, Annika Lindblom, Caroline Y. Um, Catherine M. Tangen, Chris Gignoux, Christina Newton, Christopher A. Haiman, Conghui Qu, D. Timothy Bishop, Daniel D. Buchanan, David R. Crosslin, David V. Conti, Dong-Hyun Kim, Elizabeth Hauser, Emily White, Erin Siegel, Fredrick R. Schumacher, Gad Rennert, Graham G. Giles, Heather Hampel, Hermann Brenner, Isao Oze, Jae Hwan Oh, Jeffrey K. Lee, Jennifer L. Schneider, Jenny Chang-Claude, Jeongseon Kim, Jeroen R. Huyghe, Jiayin Zheng, Jochen Hampe, Joel Greenson, John L. Hopper, Julie R. Palmer, Kala Visvanathan, Keitaro Matsuo, Koichi Matsuda, Keum Ji Jung, Li Li, Loic Le Marchand, Ludmila Vodickova, Luis Bujanda, Marc J. Gunter, Marco Matejcic, Mark A. Jenkins, Martha L. Slattery, Mauro D’Amato, Meilin Wang, Michael Hoffmeister, Michael O. Woods, Michelle Kim, Mingyang Song, Motoki Iwasaki, Mulong Du, Natalia Udaltsova, Norie Sawada, Pavel Vodicka, Peter T. Campbell, Polly A. Newcomb, Qiuyin Cai, Rachel Pearlman, Rish K. Pai, Robert E. Schoen, Robert S. Steinfelder, Robert W. Haile, Rosita Vandenputtelaar, Ross L. Prentice, Sébastien Küry, Sergi Castellví-Bel, Shoichiro Tsugane, Sonja I. Berndt, Soo Chin Lee, Stefanie Brezina, Stephanie J. Weinstein, Stephen J. Chanock, Sun Ha Jee, Sun-Seog Kweon, Susan Vadaparampil, Tabitha A. Harrison, Taiki Yamaji, Temitope O. Keku, Veronika Vymetalkova, Volker Arndt, Wei-Hua Jia, Xiao-Ou Shu, Yi Lin, Yoon-Ok Ahn, Zsofia K. Stadler, Bethany Van Guelpen, Cornelia M. Ulrich, Elizabeth A. Platz, John D. Potter, Christopher I. Li, Reinier Meester, Victor Moreno, Jane C. Figueiredo, Graham Casey, Iris Lansdorp Vogelaar, Malcolm G. Dunlop, Stephen B. Gruber, Richard B. Hayes, Paul D. P. Pharoah, Richard S. Houlston, Gail P. Jarvik, Ian P. Tomlinson, Wei Zheng, Douglas A. Corley, Ulrike Peters, Li Hsu

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Abstract Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal pe

Externí odkaz: https://doaj.org/article/e7a280372db24e62a96e2b247dd52766

Successful Design and Implementation of a POEM Program for Achalasia in an Integrated Healthcare System

Autor: Lawrence Jun Leung, Gene K. Ma, Jeffrey K. Lee, Norio Fukami, Howard Chang, Jonathan Svahn, Ming-Ming Xu, Steven Lam, Amita Risbud, Terry L. Jue

Publikováno v: Digestive Diseases and Sciences. 68:2276-2284

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df59f7e603ea199bdc02a2502bc571c3
https://doi.org/10.1007/s10620-023-07839-y

Epidemiologic Burden and Projections for Eosinophilic Esophagitis-Associated Emergency Department Visits in the United States (2009-2030)

Autor: Angela Y. Lam, Jeffrey K. Lee, Stephanie Coward, Gilaad G. Kaplan, Evan S. Dellon, Albert J. Bredenoord, Vipul Jairath, Eileen Crowley, Milli Gupta, Humberto Jijon, Yasmin Nasser, Christopher N. Andrews, Mirna Chehade, Nirmala Gonsalves, Ikuo Hirano, Christopher Ma

Publikováno v: Clinical Gastroenterology and Hepatology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e57e282f65cf59e10e21bd10431ad2f7
https://doi.org/10.1016/j.cgh.2023.04.028