Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jeffrey Jong-Young Yen"'
Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Abstract JAK2 activation is crucial for cytokine receptor signal transduction and leukemogenesis. However, the underlying processes that lead to full activation of JAK2 are unclear. Here, we report a positive role for ubiquitination of JAK2 during GM
Externí odkaz:
https://doaj.org/article/9fe6dcf64ccf458382637bd505da5e98
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64269 (2013)
We previously reported that IL-3 signaling induces phosphorylation of GATA-1 at the serine²⁶ position, which contributes to IL-3-mediated anti-apoptotic response. Here, we demonstrate that phosphorylation of GATA-1 at serine²⁶ is also transient
Externí odkaz:
https://doaj.org/article/ad8cfdd99d944b77bd154baba98a238f
Autor:
Yun-Jung Chiang, Kun-Chin Ho, Chien-Tsang Sun, Jeng-Jiann Chiu, Fang-Jen Lee, Fang Liao, Hsin-Fang Yang-Yen, Jeffrey Jong-Young Yen
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61761 (2013)
Activated chemokine receptor initiates inside-out signaling to transiently trigger activation of integrins, a process involving multiple components that have not been fully characterized. Here we report that GM-CSF/IL-3/IL-5 receptor common beta-chai
Externí odkaz:
https://doaj.org/article/88d03c9cefe94f979213ae3c9be61bb6
Publikováno v:
Blood. 93:2569-2577
In vitro proliferation of hematopoietic stem cells requires costimulation by multiple regulatory factors whereas expansion of lineage-committed progenitor cells generated by stem cells usually requires only a single factor. The distinct requirement o
Publikováno v:
Optics Express. 23:30943
The dual-color dynamic particle tracking approach that uses temporal focusing multiphoton fluorescence excitation and two-channel astigmatic imaging is utilized to track molecular trajectories in three dimensions to explore molecular interactions. Im
Publikováno v:
Vitamins and hormones. 74
Interleukin-3 (IL-3) is one of the major hematopoietic cytokines that regulate the survival of hematopoietic cells of various lineages. Although the mechanism underlying the survival effect of IL-3 has been investigated intensively for more than a de
Autor:
Ping-Hung Chen, Fan-Ching Chien, Sue-Ping Lee, Woan-Eng Chan, I.-Hsuan Lin, Chun-Shan Liu, Fang-Jen Lee, Jiann-Shiun Lai, Peilin Chen, Hsin-Fang Yang-Yen, Jeffrey Jong-Young Yen
Publikováno v:
Cell Cycle; Oct2012, Vol. 11 Issue 19, p3611-3626, 16p