Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Jeffrey J.Y. Yen"'
Autor:
Yu-yi Chu-Farseeva, Anders Poulsen, Jeffrey J.Y. Yen, Brian W. Dymock, Nurulhuda Mustafa, Wee Joo Chng, Eng Chong Tan
Publikováno v:
European Journal of Medicinal Chemistry. 158:593-619
Specifically blocking more than one oncogenic pathway simultaneously in a cancer cell with a combination of different drugs is the mainstay of the majority of cancer treatments. Being able to do this via two targeted pathways without inducing side ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903f9c48229ad4612756d30f721502c2
https://doi.org/10.1016/j.ejmech.2018.09.024
https://doi.org/10.1016/j.ejmech.2018.09.024
Autor:
Kun-Chin Ho, Lee-Yung Shih, Jeffrey J.Y. Yen, Hsin-Fang Yang-Yen, Yu-Guang Chen, Yun-Jung Chiang, Wei-Ting Liao, Shiu-Feng Huang, Shih-Hao Wang, Ching-Liang Ho
Publikováno v:
Oncogene
High-frequency relapse remains a clinical hurdle for complete remission of T-cell acute lymphoblastic leukemia (T-ALL) patients, with heterogeneous dysregulated signaling profiles—including of Raf-MEK-ERK and Akt-mTORC1-S6K signaling pathways—rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39c628dc86a60e5d22fbfbd9048564b
http://europepmc.org/articles/PMC6372575
http://europepmc.org/articles/PMC6372575
Autor:
Prachi Singh, Lianbin Yao, Pondy Murugappan Ramanujulu, Anders Poulsen, Jeannie X. T. Lee, Wee Joo Chng, Minh-Dao Duong-Thi, Nurulhuda Mustafa, Jeffrey J.Y. Yen, Brian W. Dymock, Eng Chong Tan, Sten Ohlson
Publikováno v:
Journal of Medicinal Chemistry. 60:8336-8357
Concomitant inhibition of multiple oncogenic pathways is a desirable goal in cancer therapy. To achieve such an outcome with a single molecule would simplify treatment regimes. Herein the core features of ruxolitinib (1), a marketed JAK1/2 inhibitor,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11852f322955538284fc5cdd08c36da
https://doi.org/10.1021/acs.jmedchem.7b00678
https://doi.org/10.1021/acs.jmedchem.7b00678
Autor:
Fu-Tong Liu, I-Wen Song, Ya-Jen Chang, Chun-Chou Tsai, Li-Fen Shen, Jeffrey J.Y. Yen, Hsiao-Li Chuang, Li-Ying Chen, Hsin-Fang Yang-Yen, Yuan-Tsong Chen, Liang-Tung Yang, Christina Li-Ping Thio, Yen-Te Huang, Kai-Ming Liu
Publikováno v:
Journal of Investigative Dermatology. 137:894-904
Atopic dermatitis is a complex chronic inflammatory skin disorder that results from intimate interactions among genetic predisposition, host environment, skin barrier defects, and immunological factors. However, a clear genetic roadmap leading to ato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c4327f18465bbd59401ef4a6ad10a5
https://doi.org/10.1016/j.jid.2016.12.011
https://doi.org/10.1016/j.jid.2016.12.011
Autor:
Ching-Shu Suen, Chih-Syuan Liu, Ming-Jing Hwang, Hubert W Peng, Hsin-Chou Yang, Chia-Jen Lee, Tzu-Yuan Chiu, Yu-Jen Liang, Hsin-Fang Yang-Yen, Hung-Ta Chen, Jeffrey J.Y. Yen, M. Mahmood Hussain
Publikováno v:
The Journal of Biological Chemistry
Microsomal triglyceride transfer protein (MTTP) is an endoplasmic reticulum resident protein that is essential for the assembly and secretion of triglyceride (TG)-rich, apoB-containing lipoproteins. Although the function and structure of mammalian MT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334276df232ab2d9d09c40813ec29bb7
https://doi.org/10.1074/jbc.ra120.015002
https://doi.org/10.1074/jbc.ra120.015002
Autor:
Chun-Shan Liu, Yi Huang, Ching-Yu Lai, Hsin-Fang Yang-Yen, Kun-Hai Yeh, Jeffrey J.Y. Yen, Mi-Hua Tao, Kai Xuan Tin, Jun-Yu He, Hubert W Peng, Huan-Da Chen, Hsuan Liu, Shih-Yen Weng, Yun-Jung Chiang
Publikováno v:
Oncogene. 38(3)
Aged hepatocyte-specific-Mcl-1 knockout (MKO-hep) mice are prone to develop liver tumors mimicking human hepatocellular carcinoma (HCC). Here we reported that a protein named UDP-N-acetylglucosamine pyrophosphorylase-1-like-1 (Uap1l1) is upregulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d00f2855bf136df82274df1313eaee
https://pubmed.ncbi.nlm.nih.gov/30097606
https://pubmed.ncbi.nlm.nih.gov/30097606
Autor:
Fu-Tong Liu, Yu-Ping Hsiao, Li-Chung Hsu, Yungling Leo Lee, Ming-Fong Yang, Ming-Wei Su, Jeffrey J.Y. Yen, I-Jen Wang, Nai-Wei Kuo
Publikováno v:
Journal of Dermatological Science. 79:222-228
Background Atopic dermatitis (AD) is the single most common allergic disease in children. STAT6 has been noted as a hub molecule in IL-4 mediated response and AD pathogenesis. However, the association between STAT6 genetic variants and childhood AD h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c76c2373bffcdaca2dd58d8904a382
https://doi.org/10.1016/j.jdermsci.2015.05.006
https://doi.org/10.1016/j.jdermsci.2015.05.006
Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
JAK2 activation is crucial for cytokine receptor signal transduction and leukemogenesis. However, the underlying processes that lead to full activation of JAK2 are unclear. Here, we report a positive role for ubiquitination of JAK2 during GM-CSF-indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d57d32b2737c1dc658eb0e3ddd52a6b0
https://doi.org/10.1038/s41598-017-04078-w
https://doi.org/10.1038/s41598-017-04078-w
Autor:
Yu-Ju Chen, Yuan-Tsong Chen, I-Wen Song, Jeffrey J.Y. Yen, Jer-Yuarn Wu, Li-Ying Chen, Hsiao-Yuh Roan, Li-Fen Shen, Yi-Ju Chen, Kai-Ming Liu, Amir Haddad
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports
Scientific Reports
Palmitoyltransferase (PAT) catalyses protein S-palmitoylation which adds 16-carbon palmitate to specific cysteines and contributes to various biological functions. We previously reported that in mice, deficiency of Zdhhc13, a member of the PAT family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e12eaf89e95fce7f5f1bb526f32aa8d9
https://doi.org/10.1038/s41598-017-02159-4
https://doi.org/10.1038/s41598-017-02159-4
Autor:
Chung-Leung Li, Huang-Wei Lien, Kou-Ray Lin, Hsin-Fang Yang-Yen, Liang-In Lin, Jeffrey J.Y. Yen, Chang-Jen Huang, Wei-Hao Liao
Publikováno v:
Scientific Reports
Tribbles homolog 2 (Trib2) is a member of Tribbles protein pseudokinases and involves in apoptosis, autoimmunity, cancer, leukemia and erythropoiesis, however, the physiological function of Trib2 in hematopoietic system remains to be elucidated. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0ba9ce7176a67555f9626a5543a2d1
https://doi.org/10.1038/srep31444
https://doi.org/10.1038/srep31444