Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jeffrey J. Talbot"'
Autor:
John R White, Marla Abodeely, Sammina Ahmed, Gaël Debauve, Evan Johnson, Debra M Meyer, Ned M Mozier, Matthias Naumer, Alessandra Pepe, Isam Qahwash, Edward Rocnik, Jeffrey G Smith, Elaine SE Stokes, Jeffrey J Talbot, Pin Yee Wong
Publikováno v:
BioTechniques, Vol 67, Iss 3, Pp 126-137 (2019)
Biological activity is a critical quality attribute for biopharmaceuticals, which is accurately measured using an appropriate relative potency bioassay. Developing a bioassay is a complex, rigorous undertaking that needs to address several challenges
Externí odkaz:
https://doaj.org/article/a956d410bab14152a653a980043013fe
Autor:
Masaw Akbari, Jonathan D. West, Nicholas Doerr, Kevin R. Kipp, Neda Marhamati, Sabrina Vuong, Yidi Wang, Markus M. Rinschen, Jeffrey J. Talbot, Oliver Wessely, Thomas Weimbs
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 30
Akbari, M, West, J D, Doerr, N, Kipp, K R, Marhamati, N, Vuong, S, Wang, Y, Rinschen, M M, Talbot, J J, Wessely, O & Weimbs, T 2022, ' Restoration of atypical protein kinase C ζ function in autosomal dominant polycystic kidney disease ameliorates disease progression ', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 30, e2121267119 . https://doi.org/10.1073/pnas.2121267119
Akbari, M, West, J D, Doerr, N, Kipp, K R, Marhamati, N, Vuong, S, Wang, Y, Rinschen, M M, Talbot, J J, Wessely, O & Weimbs, T 2022, ' Restoration of atypical protein kinase C ζ function in autosomal dominant polycystic kidney disease ameliorates disease progression ', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 30, e2121267119 . https://doi.org/10.1073/pnas.2121267119
Autosomal dominant polycystic kidney disease (ADPKD) affects more than 500,000 individuals in the United States alone. In most cases, ADPKD is caused by a loss-of-function mutation in the PKD1 gene, which encodes polycystin-1 (PC1). Previous studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f72725d05c6f86d382499b53f3482e3
https://escholarship.org/uc/item/0rw4q0ck
https://escholarship.org/uc/item/0rw4q0ck
Autor:
Ned M. Mozier, Gaël Debauve, Evan Johnson, Alessandra Pepe, Marla Abodeely, Matthias Naumer, Jeffrey J Talbot, Sammina Ahmed, Edward Rocnik, John R. White, Elaine Se Stokes, Pin Yee Wong, Isam Qahwash, Debra M. Meyer, Jeffrey G. Smith
Publikováno v:
BioTechniques. 67:126-137
Biological activity is a critical quality attribute for biopharmaceuticals, which is accurately measured using an appropriate relative potency bioassay. Developing a bioassay is a complex, rigorous undertaking that needs to address several challenges
Autor:
Xiaofang Wang, Jeffrey J. Talbot, Bernhard Schermer, Xuewen Song, York Pei, Vicente E. Torres, Nicholas Doerr, Thomas Weimbs, Markus M. Rinschen, Wells B. LaRiviere
Publikováno v:
Talbot, J J, Song, X, Wang, X, Rinschen, M M, Doerr, N, La Riviere, W B, Schermer, B, Pei, Y P, Torres, V E & Weimbs, T 2014, ' The cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation ', Journal of the American Society of Nephrology, vol. 25, no. 8, pp. 1737-1748 . https://doi.org/10.1681/ASN.2013091026
Polycystin-1 (PC1) mutations result in proliferative renal cyst growth and progression to renal failure in autosomal dominant polycystic kidney disease (ADPKD). The transcription factor STAT3 (signal transducer and activator of transcription 3) was s
Decisions about efficacy and safety of therapeutic proteins (TP) designed to target soluble ligands are made in part by their ex vivo quantification. Ligand binding assays (LBAs) are critical tools in measuring serum TP levels in pharmacokinetic, tox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30769d963d1ad8a2968983c00f10bbc
https://europepmc.org/articles/PMC4627453/
https://europepmc.org/articles/PMC4627453/
Publikováno v:
JAK-STAT
Autosomal-dominant polycystic kidney disease (ADPKD) is a common genetic disease caused by mutations in the gene coding for polycystin-1 (PC1). PC1 can regulate STAT transcription factors by a novel, dual mechanism. STAT3 and STAT6 are aberrantly act
Autor:
Shivakumar Vasanth, Jonathan M. Shillingford, Nicholas Doerr, Thomas Weimbs, Terry Watnick, Mike T. Kinter, Jeffrey J. Talbot, Sambuddho Mukherjee
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 108(19)
Mutations in polycystin-1 (PC1) lead to autosomal-dominant polycystic kidney disease (ADPKD), a leading cause of renal failure for which no treatment is available. PC1 is an integral membrane protein, which has been implicated in the regulation of mu
Autor:
Gass K; Lymphatic Filariasis Support Center, The Task Force for Global Health, Decatur, Georgia, United States of America., Beau de Rochars MV, Boakye D, Bradley M, Fischer PU, Gyapong J, Itoh M, Ituaso-Conway N, Joseph H, Kyelem D, Laney SJ, Legrand AM, Liyanage TS, Melrose W, Mohammed K, Pilotte N, Ottesen EA, Plichart C, Ramaiah K, Rao RU, Talbot J, Weil GJ, Williams SA, Won KY, Lammie P
Publikováno v:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2012 Jan; Vol. 6 (1), pp. e1479. Date of Electronic Publication: 2012 Jan 17.
Autor:
Talbot J; Department of Medicine, Division of Medical Oncology and Stem Cell Transplantation, Duke University Medical Center, Durham, NC 27710, USA., Ibom VK, Rizzieri DA, Barrier R, Niedzwieki D, DeCastro CM, Moore JO, Buckley P, Laney R, Stevenson D, Rumbaugh H, Gockerman JP
Publikováno v:
Clinical lymphoma [Clin Lymphoma] 2004 Sep; Vol. 5 (2), pp. 116-22.
Autor:
Talbot J, Rizzieri DA, DeCastro CM, Moore JO, Buckley P, Laney R, Stevenson D, Brumbaugh H, Gockerman JP
Publikováno v:
American journal of hematology [Am J Hematol] 2003 Aug; Vol. 73 (4), pp. 295-6.