Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jeffrey J. Heard"'
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-11 (2018)
Abstract Background RHEB is a unique member of the RAS superfamily of small GTPases expressed in all tissues and conserved from yeast to humans. Early studies on RHEB indicated a possible RHEB-RAF interaction, but this has not been fully explored. Re
Externí odkaz:
https://doaj.org/article/c6cee583b8d64227b6d1576a22829847
Publikováno v:
BMC cancer, vol 18, iss 1
BMC Cancer
BMC Cancer, Vol 18, Iss 1, Pp 1-11 (2018)
BMC Cancer
BMC Cancer, Vol 18, Iss 1, Pp 1-11 (2018)
Background RHEB is a unique member of the RAS superfamily of small GTPases expressed in all tissues and conserved from yeast to humans. Early studies on RHEB indicated a possible RHEB-RAF interaction, but this has not been fully explored. Recent work
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07cc131e9da594d4368ac047b925f799
https://escholarship.org/uc/item/6xt1z4wd
https://escholarship.org/uc/item/6xt1z4wd
Autor:
Jeffrey J. Heard, Fuyuhiko Tamanoi
Publikováno v:
Encyclopedia of Signaling Molecules ISBN: 9781461464389
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf6aaadc50e3363cd833450dc6ba6b2
https://doi.org/10.1007/978-1-4614-6438-9_101614-1
https://doi.org/10.1007/978-1-4614-6438-9_101614-1
Autor:
Christian V. Baglini, Fuyuhiko Tamanoi, John M. Asara, Jeffrey J. Heard, Alexander J. Valvezan, Menghang Xia, Brendan D. Manning, Srilatha Sakamuru, Hilaire C. Lam, Elizabeth P. Henske, Harilaos Filippakis, Ruili Huang, Christopher M. Austin, Tianmu Wen, Amine Belaid, Nguyen Truong Sinh
Publikováno v:
Clinical Cancer Research. 23:A09-A09
Tuberous sclerosis complex (TSC) is a multisystem disorder that affects multiple organ systems, including tumors of the brain, heart, kidney, skin and lung. TSC is caused by germline loss-of-function gene mutations in TSC1 or TSC2, which inhibit the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::655b449bffccc1599292f4f326caf80e
https://doi.org/10.1158/1557-3265.pmccavuln16-a09
https://doi.org/10.1158/1557-3265.pmccavuln16-a09
Autor:
Wataru Shimono, Jeffrey J. Heard, Seisuke Hattori, Hitomi Akasu, Tatsuhiro Sato, Chisa Matsu, Yoshio Shibagaki, Yuki Fujiwara, Fuyuhiko Tamanoi
Rheb small GTPases, which consist of Rheb1 and Rheb2 (also known as RhebL1) in mammalian cells, are unique members of the Ras superfamily and play central roles in regulating protein synthesis and cell growth by activating mTOR. To gain further insig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867a3189eaf03cc94da5f4c971c00312
https://europepmc.org/articles/PMC4294477/
https://europepmc.org/articles/PMC4294477/
Publikováno v:
Cellular signalling, vol 26, iss 9
In this review we highlight recent progress in the study of Rheb family GTPases. Structural studies using X-ray crystallography and NMR have given us insight into unique features of this GTPase. Combined with mutagenesis studies, these works have exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e2a120276603a968a6f4cbaddc1a59
https://escholarship.org/uc/item/0jc3g2h4
https://escholarship.org/uc/item/0jc3g2h4