Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Jeffrey J. Brault"'
Autor:
Paige L. Snider, Elizabeth A. Sierra Potchanant, Zejin Sun, Donna M. Edwards, Ka-Kui Chan, Catalina Matias, Junya Awata, Aditya Sheth, P. Melanie Pride, R. Mark Payne, Michael Rubart, Jeffrey J. Brault, Michael T. Chin, Grzegorz Nalepa, Simon J. Conway
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8201 (2024)
Cardiomyopathy is the predominant defect in Barth syndrome (BTHS) and is caused by a mutation of the X-linked Tafazzin (TAZ) gene, which encodes an enzyme responsible for remodeling mitochondrial cardiolipin. Despite the known importance of mitochond
Externí odkaz:
https://doaj.org/article/cb3ba0ddacf3416ab3d640e28074c424
Autor:
Florentina Negoita, Alex B. Addinsall, Kristina Hellberg, Conchita Fraguas Bringas, Paul S. Hafen, Tyler J. Sermersheim, Marianne Agerholm, Christopher T.A. Lewis, Danial Ahwazi, Naomi X.Y. Ling, Jeppe K. Larsen, Atul S. Deshmukh, Mohammad A. Hossain, Jonathan S. Oakhill, Julien Ochala, Jeffrey J. Brault, Uma Sankar, David H. Drewry, John W. Scott, Carol A. Witczak, Kei Sakamoto
Publikováno v:
Molecular Metabolism, Vol 75, Iss , Pp 101761- (2023)
Objective: The AMP-activated protein kinase (AMPK) gets activated in response to energetic stress such as contractions and plays a vital role in regulating various metabolic processes such as insulin-independent glucose uptake in skeletal muscle. The
Externí odkaz:
https://doaj.org/article/9d5e5d0c7c7842288457d872e1ccedfc
Autor:
Chris K. Kargl, Brian P. Sullivan, Derek Middleton, Andrew York, Lundon C. Burton, Jeffrey J. Brault, Shihuan Kuang, Timothy P. Gavin
Publikováno v:
Experimental Physiology, Vol 108, Iss 2, Pp 240-252 (2023)
Abstract Skeletal muscle capillarization is proportional to muscle fibre mitochondrial content and oxidative capacity. Skeletal muscle cells secrete many factors that regulate neighbouring capillary endothelial cells (ECs), including extracellular ve
Externí odkaz:
https://doaj.org/article/6de3d5d9ec1c4028a8ed480cbff72c12
Autor:
Jake T. Francisco, Andrew W. Holt, Michael T. Bullock, Madison D. Williams, Cere E. Poovey, Nathan A. Holland, Jeffrey J. Brault, David A. Tulis
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Transition of arterial smooth muscle (ASM) from a quiescent, contractile state to a growth-promoting state is a hallmark of cardiovascular disease (CVD), a leading cause of death and disability in the United States and worldwide. While many individua
Externí odkaz:
https://doaj.org/article/179e72c21d1f48ea9f00b8de85ef5036
Autor:
Shawna L. McMillin, Erin C. Stanley, Luke A. Weyrauch, Jeffrey J. Brault, Barbara B. Kahn, Carol A. Witczak
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4913 (2021)
Denervation rapidly induces insulin resistance (i.e., impairments in insulin-stimulated glucose uptake and signaling proteins) in skeletal muscle. Surprisingly, whether this metabolic derangement is long-lasting is presently not clear. The main goal
Externí odkaz:
https://doaj.org/article/2897cecf57834917adce9aa30320ceed
Publikováno v:
Cells, Vol 9, Iss 12, p 2536 (2020)
Cancer cachexia (CC) is a debilitating multifactorial syndrome, involving progressive deterioration and functional impairment of skeletal muscles. It affects about 80% of patients with advanced cancer and causes premature death. No causal therapy is
Externí odkaz:
https://doaj.org/article/76716abd8b744d3e98147ae84ad9b448
Autor:
Chris K. Kargl, Brian P. Sullivan, Derek Middleton, Andrew York, Lundon C. Burton, Jeffrey J. Brault, Shihuan Kuang, Timothy P. Gavin
Publikováno v:
Experimental Physiology. 108:240-252
What is the central question of this study? Skeletal muscle extracellular vesicles likely act as pro-angiogenic signalling factors: does overexpression of peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) alter skeletal muscle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48cb54d552f6e1839ee220b205f771ff
https://doi.org/10.1113/ep090874
https://doi.org/10.1113/ep090874
Autor:
Cameron A Schmidt, Emma J Goldberg, Tom D Green, Reema R Karnekar, Jeffrey J Brault, Spencer G Miller, Adam J Amorese, Dean J Yamaguchi, Espen E Spangenburg, Joseph M McClung
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0225922 (2020)
Stored muscle carbohydrate supply and energetic efficiency constrain muscle functional capacity during exercise and are influenced by common physiological variables (e.g. age, diet, and physical activity level). Whether these constraints affect overa
Externí odkaz:
https://doaj.org/article/3f3a933d89974689ad73794a5bb1e8f2
Publikováno v:
Journal of Applied Physiology. 133:1055-1066
AMP deaminase 1 (AMPD1) deficiency has been associated with premature muscle fatigue and reduced work capacity, but this finding has been inconsistent. Herein, we report that although AMPD1 knockdown in mouse skeletal muscle does not change maximal i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b41579a1a30a3bd8cc7d3152098db6ec
https://doi.org/10.1152/japplphysiol.00035.2022
https://doi.org/10.1152/japplphysiol.00035.2022
Autor:
James T. Hagen, McLane M. Montgomery, Ericka M. Biagioni, Polina Krassovskaia, Filip Jevtovic, Daniel Shookster, Uma Sharma, Kang Tung, Nickolas T. Broskey, Linda May, Hu Huang, Jeffrey J. Brault, P. Darrell Neufer, Myles C. Cabot, Kelsey H. Fisher-Wellman
Publikováno v:
Biochimica et biophysica acta. Bioenergetics. 1863(8)
Although the development of chemoresistance is multifactorial, active chemotherapeutic efflux driven by upregulations in ATP binding cassette (ABC) transporters are commonplace. Chemotherapeutic efflux pumps, like ABCB1, couple drug efflux to ATP hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e78a7d85682528d0ff2efad03019af3
https://pubmed.ncbi.nlm.nih.gov/36058252
https://pubmed.ncbi.nlm.nih.gov/36058252