Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jeffrey J Szymanski"'
Autor:
Nicholas P Semenkovich, Jeffrey J Szymanski, Noah Earland, Pradeep S Chauhan, Bruna Pellini, Aadel A Chaudhuri
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 6 (2023)
Liquid biopsies using cell-free circulating tumor DNA (ctDNA) are being used frequently in both research and clinical settings. ctDNA can be used to identify actionable mutations to personalize systemic therapy, detect post-treatment minimal residual
Externí odkaz:
https://doaj.org/article/7c6b8bcfc37e4bfcb3631d1649db6f45
Autor:
Pradeep S Chauhan, Kevin Chen, Ramandeep K Babbra, Wenjia Feng, Nadja Pejovic, Armaan Nallicheri, Peter K Harris, Katherine Dienstbach, Andrew Atkocius, Lenon Maguire, Faridi Qaium, Jeffrey J Szymanski, Brian C Baumann, Li Ding, Dengfeng Cao, Melissa A Reimers, Eric H Kim, Zachary L Smith, Vivek K Arora, Aadel A Chaudhuri
Publikováno v:
PLoS Medicine, Vol 18, Iss 8, p e1003732 (2021)
BackgroundThe standard of care treatment for muscle-invasive bladder cancer (MIBC) is radical cystectomy, which is typically preceded by neoadjuvant chemotherapy. However, the inability to assess minimal residual disease (MRD) noninvasively limits ou
Externí odkaz:
https://doaj.org/article/68ac59a93c0e4cf082db6dfecd686ee0
Autor:
Jeffrey J Szymanski, R Taylor Sundby, Paul A Jones, Divya Srihari, Noah Earland, Peter K Harris, Wenjia Feng, Faridi Qaium, Haiyan Lei, David Roberts, Michele Landeau, Jamie Bell, Yi Huang, Leah Hoffman, Melissa Spencer, Matthew B Spraker, Li Ding, Brigitte C Widemann, Jack F Shern, Angela C Hirbe, Aadel A Chaudhuri
Publikováno v:
PLoS Medicine, Vol 18, Iss 8, p e1003734 (2021)
BackgroundThe leading cause of mortality for patients with the neurofibromatosis type 1 (NF1) cancer predisposition syndrome is the development of malignant peripheral nerve sheath tumor (MPNST), an aggressive soft tissue sarcoma. In the setting of N
Externí odkaz:
https://doaj.org/article/c4e51b3f384e4d0d940d39076a2a352f
Autor:
Isidro, Cortes-Ciriano, Christopher D, Steele, Katherine, Piculell, Alyaa, Al-Ibraheemi, Vanessa, Eulo, Marilyn M, Bui, Aikaterini, Chatzipli, Brendan C, Dickson, Dana C, Borcherding, Andrew, Feber, Alon, Galor, Jesse, Hart, Kevin B, Jones, Justin T, Jordan, Raymond H, Kim, Daniel, Lindsay, Colin, Miller, Yoshihiro, Nishida, Paula Z, Proszek, Jonathan, Serrano, R Taylor, Sundby, Jeffrey J, Szymanski, Nicole J, Ullrich, David, Viskochil, Xia, Wang, Matija, Snuderl, Peter J, Park, Adrienne M, Flanagan, Angela C, Hirbe, Nischalan, Pillay, David T, Miller
Publikováno v:
Cancer Discovery. 13:654-671
Malignant peripheral nerve sheath tumor (MPNST), an aggressive soft-tissue sarcoma, occurs in people with neurofibromatosis type 1 (NF1) and sporadically. Whole-genome and multiregional exome sequencing, transcriptomic, and methylation profiling of 9
Autor:
David T. Miller, Nischalan Pillay, Angela C. Hirbe, Adrienne M. Flanagan, Peter J. Park, Matija Snuderl, Xia Wang, David Viskochil, Nicole J. Ullrich, Jeffrey J. Szymanski, R. Taylor Sundby, Jonathan Serrano, Paula Z. Proszek, Yoshihiro Nishida, Colin Miller, Daniel Lindsay, Raymond H. Kim, Justin T. Jordan, Kevin B. Jones, Jesse Hart, Alon Galor, Andrew Feber, Dana C. Borcherding, Brendan C. Dickson, Aikaterini Chatzipli, Marilyn M. Bui, Vanessa Eulo, Alyaa Al-Ibraheemi, Katherine Piculell, Christopher D. Steele, Isidro Cortes-Ciriano
Supplementary Table 1 includes the metadata on all subjects, including basic demographics and medical history. Supplementary Table 2 provides statistics on chrom 8 gene expression among tumors with H3K27me3 loss. Note: no changes have been made to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15deb6bdcb75389ac6ff3546033511c4
https://doi.org/10.1158/2159-8290.22542118.v1
https://doi.org/10.1158/2159-8290.22542118.v1
Autor:
David T. Miller, Nischalan Pillay, Angela C. Hirbe, Adrienne M. Flanagan, Peter J. Park, Matija Snuderl, Xia Wang, David Viskochil, Nicole J. Ullrich, Jeffrey J. Szymanski, R. Taylor Sundby, Jonathan Serrano, Paula Z. Proszek, Yoshihiro Nishida, Colin Miller, Daniel Lindsay, Raymond H. Kim, Justin T. Jordan, Kevin B. Jones, Jesse Hart, Alon Galor, Andrew Feber, Dana C. Borcherding, Brendan C. Dickson, Aikaterini Chatzipli, Marilyn M. Bui, Vanessa Eulo, Alyaa Al-Ibraheemi, Katherine Piculell, Christopher D. Steele, Isidro Cortes-Ciriano
Supplementary figures provide additional details on the genomic landscape of MPNST and interesting cases within the cohort.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161b5a8bac5dc55c121b8f13371bedb4
https://doi.org/10.1158/2159-8290.22542121
https://doi.org/10.1158/2159-8290.22542121
Autor:
David T. Miller, Nischalan Pillay, Angela C. Hirbe, Adrienne M. Flanagan, Peter J. Park, Matija Snuderl, Xia Wang, David Viskochil, Nicole J. Ullrich, Jeffrey J. Szymanski, R. Taylor Sundby, Jonathan Serrano, Paula Z. Proszek, Yoshihiro Nishida, Colin Miller, Daniel Lindsay, Raymond H. Kim, Justin T. Jordan, Kevin B. Jones, Jesse Hart, Alon Galor, Andrew Feber, Dana C. Borcherding, Brendan C. Dickson, Aikaterini Chatzipli, Marilyn M. Bui, Vanessa Eulo, Alyaa Al-Ibraheemi, Katherine Piculell, Christopher D. Steele, Isidro Cortes-Ciriano
Malignant peripheral nerve sheath tumor (MPNST), an aggressive soft-tissue sarcoma, occurs in people with neurofibromatosis type 1 (NF1) and sporadically. Whole-genome and multiregional exome sequencing, transcriptomic, and methylation profiling of 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae70edd78830fc820d4ca5d1771d9b86
https://doi.org/10.1158/2159-8290.c.6549805.v1
https://doi.org/10.1158/2159-8290.c.6549805.v1
Autor:
Noah Earland, Ricardo J. Ramirez, Sophie P. Gerndt, Peter K. Harris, Andrew I. Hearn, Matthew Inkman, Jeffrey J. Szymanski, Nick Semenkovich, Benjamin M. Wahle, Zhongping Xu, Kevin Chen, Jin Zhang, Jose P. Zevallos, Aadel A. Chaudhuri
Publikováno v:
Cancer Research. 83:3359-3359
Background: Plasma cell-free DNA (cfDNA) has low sensitivity to detect locoregional molecular residual disease (MRD) immediately after surgery for limited-stage head and neck cancer. To enhance locoregional MRD sensitivity, we utilize a novel bioflui
Autor:
Alex C. Pan, Russell Taylor Sundby, Jeffrey J. Szymanski, Paul A. Jones, Peter K. Harris, Aadel A. Chaudhuri, Angela C. Hirbe, Jack F. Shern
Publikováno v:
Cancer Research. 83:997-997
Background: Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft tissue sarcomas that, in the setting of neurofibromatosis type 1 (NF1), arise within pre-malignant atypical neurofibroma (AN) and benign plexiform neurofibroma (PN). Ear
Publikováno v:
Thoracic Surgery Clinics. 30:165-177
Liquid biopsies for the diagnosis and treatment of lung cancer have developed rapidly, driven primarily by technical advances in sensitivity to detect circulating tumor DNA (ctDNA). Still, technical limitations such as the challenge of detecting low-