Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Jeffrey J Nirschl"'
Autor:
James Burgess, Jeffrey J. Nirschl, Maria-Clara Zanellati, Alejandro Lozano, Sarah Cohen, Serena Yeung-Levy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Cell and organelle shape are driven by diverse genetic and environmental factors and thus accurate quantification of cellular morphology is essential to experimental cell biology. Autoencoders are a popular tool for unsupervised biological i
Externí odkaz:
https://doaj.org/article/33743fd36fa843539f8c6a0dacba302d
Autor:
Ragini Phansalkar, Vanessa S. Goodwill, Jeffrey J. Nirschl, Chiara De Lillo, Jihee Choi, Elizabeth Spurlock, David G. Coughlin, Donald Pizzo, Christina J. Sigurdson, Annie Hiniker, Victor E. Alvarez, Ann C. Mckee, Jonathan H. Lin
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-10 (2023)
Abstract Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive head trauma. Brain pathology in CTE is characterized by neuronal loss, gliosis, and a distinctive pattern of neuronal accumulation of hyper-phos
Externí odkaz:
https://doaj.org/article/612dc488fe0f423f8daedf3b82d74059
Autor:
Rebecca Rojansky, Iny Jhun, Alex M. Dussaq, Steven M. Chirieleison, Jeffrey J. Nirschl, Don Born, Jennifer Fralick, William Hetherington, Alison M. Kerr, Jonathan Lavezo, Daniel B. Lawrence, Seth Lummus, Ronald Macasaet, Thomas J. Montine, Emily Ryan, Jeanne Shen, Jonathan Shoemaker, Brent Tan, Hannes Vogel, Puneet Singh Waraich, Eric Yang, April Young, Ann Folkins
Publikováno v:
Arch Pathol Lab Med
Context.— Stanford Pathology began stepwise subspecialty implementation of whole slide imaging (WSI) in 2018 soon after the first US Food and Drug Administration approval. In 2020, during the COVID-19 pandemic, the Centers for Medicare & Medicaid S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e507e276f7b6aca023e16d3027de6559
https://europepmc.org/articles/PMC9904534/
https://europepmc.org/articles/PMC9904534/
Publikováno v:
Cell Reports, Vol 14, Iss 11, Pp 2637-2652 (2016)
Motor-cargo recruitment to microtubules is often the rate-limiting step of intracellular transport, and defects in this recruitment can cause neurodegenerative disease. Here, we use in vitro reconstitution assays with single-molecule resolution, live
Externí odkaz:
https://doaj.org/article/4c3ab9da012e4f009a757c57534e57ab
Datasets supporting the publication, "Learning orientation-invariant representations enables accurate and robust morphologic profiling of cells and organelles". Dataset 1,PCST: Profiling Cell Shape and Texture (PCST) benchmark Synthetic dataset creat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274a5e163460a338f413b497025bf068
Autor:
Jeffrey J Nirschl, Andrew Janowczyk, Eliot G Peyster, Renee Frank, Kenneth B Margulies, Michael D Feldman, Anant Madabhushi
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0192726 (2018)
Over 26 million people worldwide suffer from heart failure annually. When the cause of heart failure cannot be identified, endomyocardial biopsy (EMB) represents the gold-standard for the evaluation of disease. However, manual EMB interpretation has
Externí odkaz:
https://doaj.org/article/2f4dbaa4212a45ddb27b7857b0b4b974
Autor:
David S Rogawski, Jeffrey J Nirschl, Jamie McDonald, Esther Nie, Nicholas U Schwartz, Hannes Vogel, Brian J Scott, Carl A Gold, Lucas B Kipp
Publikováno v:
Mult Scler
Primary central nervous system (CNS) histiocytic sarcoma is a rare hematolymphoid malignancy with features of mature histiocytes and carries a poor prognosis. We describe a unique case in which a 50-year-old woman presented with recurrent acute brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd517f3032628e1b81174608d74f67a
https://europepmc.org/articles/PMC9942914/
https://europepmc.org/articles/PMC9942914/
Autor:
Jennifer D. McBride, Bin Zhang, Kurt R. Brunden, Lakshmi Changolkar, Virginia M.-Y. Lee, Jeffrey J. Nirschl, Kevt’her Hoxha, John Q. Trojanowski, Hong Xu, Garrett S. Gibbons, Gerard D. Schellenberg, Mia O’Reilly, Soo-Jung Kim, Dawn M. Riddle, Anna Stieber
Publikováno v:
Acta Neuropathologica
The microtubule-associated protein tau (tau) forms hyperphosphorylated aggregates in the brains of tauopathy patients that can be pathologically and biochemically defined as distinct tau strains. Recent studies show that these tau strains exhibit str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7bfc6721968f29707c0c097e52f976d
http://europepmc.org/articles/PMC7847465
http://europepmc.org/articles/PMC7847465
Autor:
Andre Esteva, Jörg Sander, Joshua Wheeler, Talent Theparee, Osama Mohamad, Lara Richer, Felix Y. Feng, Rebecca Rojansky, Jeffrey J. Nirschl, Iny Jhun, Douwe van der Wal, Richard Socher, Israa Laklouk
Biology has become a prime area for the deployment of deep learning and artificial intelligence (AI), enabled largely by the massive datasets that the field can generate. Key to most AI tasks is the availability of a sufficiently large, labeled datas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c7e0e4f32803bde66b8cf7bea8d6227
https://doi.org/10.21203/rs.3.rs-146086/v1
https://doi.org/10.21203/rs.3.rs-146086/v1
Autor:
Steven Andrew Baker, Hannes Vogel, Thomas J. Montine, Jeffrey J. Nirschl, Chandresh R. Gajera, Adam M. Wawro
Publikováno v:
Journal of inherited metabolic diseaseREFERENCES. 44(4)
The severe impact on brain function and lack of effective therapy for patients with creatine (Cr) transporter deficiency motivated the generation of three ubiquitous Slc6a8 deficient mice (-/y). While each mouse knock-out line has similar behavioral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98b2ab3fdd68261ba9c8d8b07a2b48c0
https://pubmed.ncbi.nlm.nih.gov/33389772
https://pubmed.ncbi.nlm.nih.gov/33389772