Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Jeffrey J Brault"'
Autor:
Cameron A Schmidt, Emma J Goldberg, Tom D Green, Reema R Karnekar, Jeffrey J Brault, Spencer G Miller, Adam J Amorese, Dean J Yamaguchi, Espen E Spangenburg, Joseph M McClung
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0225922 (2020)
Stored muscle carbohydrate supply and energetic efficiency constrain muscle functional capacity during exercise and are influenced by common physiological variables (e.g. age, diet, and physical activity level). Whether these constraints affect overa
Externí odkaz:
https://doaj.org/article/3f3a933d89974689ad73794a5bb1e8f2
Autor:
Chris K. Kargl, Brian P. Sullivan, Derek Middleton, Andrew York, Lundon C. Burton, Jeffrey J. Brault, Shihuan Kuang, Timothy P. Gavin
Publikováno v:
Experimental Physiology, Vol 108, Iss 2, Pp 240-252 (2023)
Abstract Skeletal muscle capillarization is proportional to muscle fibre mitochondrial content and oxidative capacity. Skeletal muscle cells secrete many factors that regulate neighbouring capillary endothelial cells (ECs), including extracellular ve
Externí odkaz:
https://doaj.org/article/6de3d5d9ec1c4028a8ed480cbff72c12
Autor:
Florentina Negoita, Alex B. Addinsall, Kristina Hellberg, Conchita Fraguas Bringas, Paul S. Hafen, Tyler J. Sermersheim, Marianne Agerholm, Christopher T.A. Lewis, Danial Ahwazi, Naomi X.Y. Ling, Jeppe K. Larsen, Atul S. Deshmukh, Mohammad A. Hossain, Jonathan S. Oakhill, Julien Ochala, Jeffrey J. Brault, Uma Sankar, David H. Drewry, John W. Scott, Carol A. Witczak, Kei Sakamoto
Publikováno v:
Molecular Metabolism, Vol 75, Iss , Pp 101761- (2023)
Objective: The AMP-activated protein kinase (AMPK) gets activated in response to energetic stress such as contractions and plays a vital role in regulating various metabolic processes such as insulin-independent glucose uptake in skeletal muscle. The
Externí odkaz:
https://doaj.org/article/9d5e5d0c7c7842288457d872e1ccedfc
Autor:
Jake T. Francisco, Andrew W. Holt, Michael T. Bullock, Madison D. Williams, Cere E. Poovey, Nathan A. Holland, Jeffrey J. Brault, David A. Tulis
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Transition of arterial smooth muscle (ASM) from a quiescent, contractile state to a growth-promoting state is a hallmark of cardiovascular disease (CVD), a leading cause of death and disability in the United States and worldwide. While many individua
Externí odkaz:
https://doaj.org/article/179e72c21d1f48ea9f00b8de85ef5036
Autor:
Chris K. Kargl, Brian P. Sullivan, Derek Middleton, Andrew York, Lundon C. Burton, Jeffrey J. Brault, Shihuan Kuang, Timothy P. Gavin
Publikováno v:
Experimental Physiology. 108:240-252
What is the central question of this study? Skeletal muscle extracellular vesicles likely act as pro-angiogenic signalling factors: does overexpression of peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) alter skeletal muscle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48cb54d552f6e1839ee220b205f771ff
https://doi.org/10.1113/ep090874
https://doi.org/10.1113/ep090874
Publikováno v:
Journal of Applied Physiology. 133:1055-1066
AMP deaminase 1 (AMPD1) deficiency has been associated with premature muscle fatigue and reduced work capacity, but this finding has been inconsistent. Herein, we report that although AMPD1 knockdown in mouse skeletal muscle does not change maximal i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b41579a1a30a3bd8cc7d3152098db6ec
https://doi.org/10.1152/japplphysiol.00035.2022
https://doi.org/10.1152/japplphysiol.00035.2022
Autor:
James T. Hagen, McLane M. Montgomery, Ericka M. Biagioni, Polina Krassovskaia, Filip Jevtovic, Daniel Shookster, Uma Sharma, Kang Tung, Nickolas T. Broskey, Linda May, Hu Huang, Jeffrey J. Brault, P. Darrell Neufer, Myles C. Cabot, Kelsey H. Fisher-Wellman
Publikováno v:
Biochimica et biophysica acta. Bioenergetics. 1863(8)
Although the development of chemoresistance is multifactorial, active chemotherapeutic efflux driven by upregulations in ATP binding cassette (ABC) transporters are commonplace. Chemotherapeutic efflux pumps, like ABCB1, couple drug efflux to ATP hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e78a7d85682528d0ff2efad03019af3
https://pubmed.ncbi.nlm.nih.gov/36058252
https://pubmed.ncbi.nlm.nih.gov/36058252
Autor:
James E. Cox, Espen E. Spangenburg, Hu Huang, Piyarat Siripoksup, William L. Holland, Jeffrey J. Brault, Chien-Te Lin, J. Alan Maschek, Edward J. Wentzler, Dennis E. Vance, Christopher W. Paran, Hiroaki Eshima, Scott A. Summers, Jordan M. Johnson, Claudio J. Villanueva, Trevor S. Tippetts, Anthony R.P. Verkerke, Brenton Thomas Laing, Katsuhiko Funai, Terence E. Ryan, Patrick J Ferrara, P. Darrell Neufer
Publikováno v:
Nature metabolism, vol 1, iss 9
The biophysical environment of membrane phospholipids affects structure, function, and stability of membrane-bound proteins.1,2 Obesity can disrupt membrane lipids, and in particular, alter the activity of sarco/endoplasmic reticulum (ER/SR) Ca2+-ATP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eba5deea9e3dd44602a7661fd78a8ec
https://doi.org/10.1038/s42255-019-0111-2
https://doi.org/10.1038/s42255-019-0111-2
Publikováno v:
Journal of Chromatography B. 1206:123351
ATP and its degradation products are essential metabolic and signaling molecules. Traditionally, they have been quantified via high-performance liquid chromatography (HPLC) with UV-Vis detection while utilizing phosphate buffer mobile phase, but this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb410c5e8b361f2f69bcefae6a868779
https://doi.org/10.1016/j.jchromb.2022.123351
https://doi.org/10.1016/j.jchromb.2022.123351
Autor:
Carol A. Witczak, Shawna L. McMillin, Jeffrey J. Brault, Luke A. Weyrauch, Erin C. Stanley, Barbara B. Kahn
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4913, p 4913 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 9
International Journal of Molecular Sciences
Volume 22
Issue 9
Denervation rapidly induces insulin resistance (i.e., impairments in insulin-stimulated glucose uptake and signaling proteins) in skeletal muscle. Surprisingly, whether this metabolic derangement is long-lasting is presently not clear. The main goal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ced5fba25fa0d8d9883dcf476f5164
https://www.mdpi.com/1422-0067/22/9/4913
https://www.mdpi.com/1422-0067/22/9/4913