Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Jeffrey J, Tabor"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Gene expression noise can reduce fitness but analysis is hampered by a scaling relationship between noise and expression level. Here the authors show that gene expression mean and noise can be independently controlled by expressing two copies of a ge
Externí odkaz:
https://doaj.org/article/37132251cd3a4015b9689403fd278277
Autor:
John T Sexton, Jeffrey J Tabor
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 7, Pp 1-14 (2020)
Abstract The engineering of advanced multicellular behaviors, such as the programmed growth of biofilms or tissues, requires cells to communicate multiple aspects of physiological information. Unfortunately, few cell‐cell communication systems have
Externí odkaz:
https://doaj.org/article/5498fe884f5945129bd773e31091e40e
Autor:
Sebastian M. Castillo-Hair, Elliot A. Baerman, Masaya Fujita, Oleg A. Igoshin, Jeffrey J. Tabor
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Bacillus subtilis has complex spatial and temporal gene expression patterns but currently lacks optogenetic tools to explore these processes. Here the authors import and debug a cyanobacterial green light sensor pathway and show that it enables preci
Externí odkaz:
https://doaj.org/article/3e7f5ad0191741118843857e0ec93057
Autor:
Lucas A Hartsough, Mooncheol Park, Matthew V Kotlajich, John Tyler Lazar, Bing Han, Chih-Chun J Lin, Elena Musteata, Lauren Gambill, Meng C Wang, Jeffrey J Tabor
Publikováno v:
eLife, Vol 9 (2020)
Gut microbial metabolism is associated with host longevity. However, because it requires direct manipulation of microbial metabolism in situ, establishing a causal link between these two processes remains challenging. We demonstrate an optogenetic me
Externí odkaz:
https://doaj.org/article/6f776754ae384b3780c2adadc3fed1cb
Autor:
Kathryn R. Brink, Maxwell G. Hunt, Andrew M. Mu, Ken Groszman, Ky V. Hoang, Kevin P. Lorch, Brett H. Pogostin, John S. Gunn, Jeffrey J. Tabor
Publikováno v:
Nature Chemical Biology. 19:451-459
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d0790c1801affb48d3fd49727f4d098
https://doi.org/10.1038/s41589-022-01207-z
https://doi.org/10.1038/s41589-022-01207-z
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Two-component systems are a major family of signal transduction pathways and a rich source of sensors for biotechnology. Here, the authors develop a general method for rationally tuning two-component system input detection thresholds via specific poi
Externí odkaz:
https://doaj.org/article/a069825d5bfc4f6fb4d7b7972a4f7638
Autor:
Kristina N‐M Daeffler, Jeffrey D Galley, Ravi U Sheth, Laura C Ortiz‐Velez, Christopher O Bibb, Noah F Shroyer, Robert A Britton, Jeffrey J Tabor
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 4, Pp 1-13 (2017)
Abstract There is a groundswell of interest in using genetically engineered sensor bacteria to study gut microbiota pathways, and diagnose or treat associated diseases. Here, we computationally identify the first biological thiosulfate sensor and an
Externí odkaz:
https://doaj.org/article/7129d61cd9c54e3b96037757c869c69f
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 4, Pp 1-13 (2017)
Abstract Optogenetics combines externally applied light signals and genetically engineered photoreceptors to control cellular processes with unmatched precision. Here, we develop a mathematical model of wavelength‐ and intensity‐dependent photoco
Externí odkaz:
https://doaj.org/article/e014e49d70f5460fb2633d38c5216c57
Autor:
Jacob, Beal, Brian, Teague, John T, Sexton, Sebastian, Castillo-Hair, Nicholas A, DeLateur, Meher, Samineni, Jeffrey J, Tabor, Ron, Weiss
Publikováno v:
ACS Synthetic Biology. 11:1196-1207
Reliable, predictable engineering of cellular behavior is one of the key goals of synthetic biology. As the field matures, biological engineers will become increasingly reliant on computer models that allow for the rapid exploration of design space p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea15f47eb42e0610ce1e465ca232309
https://doi.org/10.1021/acssynbio.1c00488
https://doi.org/10.1021/acssynbio.1c00488
Autor:
Ryan J. Butcher, Jeffrey J. Tabor
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(35)
Bacteria utilize two-component system (TCS) signal transduction pathways to sense and adapt to changing environments. In a typical TCS, a stimulus induces a sensor histidine kinase (SHK) to phosphorylate a response regulator (RR), which then dimerize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9683ab0eecab8c8db265042f6b0a19c0
https://pubmed.ncbi.nlm.nih.gov/35994658
https://pubmed.ncbi.nlm.nih.gov/35994658