Pan-tumor survey of ROS1 fusions detected by next-generation RNA and whole transcriptome sequencing

Autor: Misako Nagasaka, Shannon S. Zhang, Yasmine Baca, Joanne Xiu, Jorge Nieva, Ari Vanderwalde, Jeffrey J. Swensen, David Spetzler, Wolfgang Michael Korn, Luis E. Raez, Stephen V. Liu, Sai-Hong Ignatius Ou

Publikováno v: BMC Cancer, Vol 23, Iss 1, Pp 1-11 (2023)

Abstract Background Two ROS1 tyrosine kinase inhibitors have been approved for ROS1 fusion positive (ROS1+) non-small cell lung cancer (NSCLC) tumors. We performed a pan-tumor analysis of the incidence of ROS1 fusions to assess if more ROS1+ patients

Externí odkaz: https://doaj.org/article/05a3d80854dc433ca5dd01303b8437af

Identification of Novel CDH1-NRG2α and F11R-NRG2α Fusions in NSCLC Plus Additional Novel NRG2α Fusions in Other Solid Tumors by Whole Transcriptome Sequencing

Autor: Sai-Hong Ignatius Ou, MD, PhD, Joanne Xiu, PhD, Misako Nagasaka, MD, Bing Xia, MD, Shannon S. Zhang, MD, Qing Zhang, PhD, Jeffrey J. Swensen, PhD, David Spetzler, MS, PhD, MBA, Wolfgang Michael Korn, MD, Viola W. Zhu, MD, PhD, Stephen V. Liu, MD

Publikováno v: JTO Clinical and Research Reports, Vol 2, Iss 2, Pp 100132- (2021)

Introduction: A novel CD74-NRG2α fusion has recently been identified in NSCLC. We surveyed a large tumor database comprehensively profiled by whole transcriptome sequencing to investigate the incidence and distribution of NRG2 fusions among various

Externí odkaz: https://doaj.org/article/ac0c0482fe5145d4bdb2310e09e643cc

Constitutional mismatch repair deficiency presenting in childhood as three simultaneous malignancies

Autor: Andrew W, Walter, Sara, Ennis, Hunter, Best, Cecily P, Vaughn, Jeffrey J, Swensen, Amanda, Openshaw, Karen W, Gripp

Publikováno v: Pediatric bloodcancer. 60(11)

A 13-year-old child presented with three simultaneous malignancies: glioblastoma multiforme, Burkitt lymphoma, and colonic adenocarcinoma. She was treated for her diseases without success and died 8 months after presentation. Genetic analysis reveale

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7eba450707228d104913b8ac52996554
https://pubmed.ncbi.nlm.nih.gov/23729388

Effect of Modification Strategies on the Biological Activity of Peptides/Proteins.

Autor: Ma J; School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China., Yan L; School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China., Yang J; School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China., He Y; School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.; School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China., Wu L; School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.; School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.

Publikováno v: Chembiochem : a European journal of chemical biology [Chembiochem] 2024 Feb 01; Vol. 25 (3), pp. e202300481. Date of Electronic Publication: 2023 Dec 08.

WHAT DOES CHOICE REALLY MEAN?: PRENATAL TESTING, DISABILITY, AND SPECIAL EDUCATION WITHOUT ILLUSIONS.

Autor: Pergament, Deborah¹

Publikováno v: Health Matrix: Journal of Law-Medicine. Spring2013, Vol. 23 Issue 1, p55-117. 63p.