Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jeffrey J, Okoro"'
Autor:
Chiara Ambrogio, Pasi A. Jänne, Mark M. Awad, Prafulla C. Gokhale, David Santamaria, Marie-Julie Nokin, Elodie Richard, Yunhan Chen, Kshiti H. Dholakia, Jens Köhler, Amanda J. Redig, Chhayheng Chhoeu, Joao Victor Alessi, Yue Xu, Jiaqi Li, Heidi M. Haikala, Mika Lin, Haiyun Wang, Raymond Paranal, Xinan Wang, Yoonji Eum, Enrico Patrucco, Alessia Mira, Jeffrey J. Okoro, Jieun Son, Biagio Ricciuti
Supplementary Data from Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non–Small Cell Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e908ecdb4bf36d5ab7cc98336d10d7d
https://doi.org/10.1158/1078-0432.22484111.v1
https://doi.org/10.1158/1078-0432.22484111.v1
Autor:
Chiara Ambrogio, Pasi A. Jänne, Mark M. Awad, Prafulla C. Gokhale, David Santamaria, Marie-Julie Nokin, Elodie Richard, Yunhan Chen, Kshiti H. Dholakia, Jens Köhler, Amanda J. Redig, Chhayheng Chhoeu, Joao Victor Alessi, Yue Xu, Jiaqi Li, Heidi M. Haikala, Mika Lin, Haiyun Wang, Raymond Paranal, Xinan Wang, Yoonji Eum, Enrico Patrucco, Alessia Mira, Jeffrey J. Okoro, Jieun Son, Biagio Ricciuti
Purpose:Activating missense mutations of KRAS are the most frequent oncogenic driver events in lung adenocarcinoma (LUAD). However, KRAS isoforms are highly heterogeneous, and data on the potential isoform-dependent therapeutic vulnerabilities are st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a622d7dd524d9e4c7db5d7f6e4ccfdc
https://doi.org/10.1158/1078-0432.c.6531326
https://doi.org/10.1158/1078-0432.c.6531326
Autor:
Hua Jin, Jiaqi Li, Kenneth D. Westover, Lianbo Li, Pasi A. Jänne, Jieun Son, Asim K. Bera, Sudershan R. Gondi, Chiara Ambrogio, Qing Li, Cheng Xiong Xu, Emily Campbell, Zhi Wei Zhou, Xing Xiao Li, Jeffrey J. Okoro
Publikováno v:
Cancer Research. 80:3719-3731
Assembly of RAS molecules into complexes at the cell membrane is critical for RAS signaling. We previously showed that oncogenic KRAS codon 61 mutations increase its affinity for RAF, raising the possibility that KRASQ61H, the most common KRAS mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980ad40f48a7ef5e60e0f28a76e5664e
https://doi.org/10.1158/0008-5472.can-20-0448
https://doi.org/10.1158/0008-5472.can-20-0448
Autor:
Biagio Ricciuti, Jieun Son, Jeffrey J. Okoro, Alessia Mira, Enrico Patrucco, Yoonji Eum, Xinan Wang, Raymond Paranal, Haiyun Wang, Mika Lin, Heidi M. Haikala, Jiaqi Li, Yue Xu, Joao Victor Alessi, Chhayheng Chhoeu, Amanda J. Redig, Jens Köhler, Kshiti H. Dholakia, Yunhan Chen, Elodie Richard, Marie-Julie Nokin, David Santamaria, Prafulla C. Gokhale, Mark M. Awad, Pasi A. Jänne, Chiara Ambrogio
Publikováno v:
Clinical Cancer Research
Purpose:Activating missense mutations of KRAS are the most frequent oncogenic driver events in lung adenocarcinoma (LUAD). However, KRAS isoforms are highly heterogeneous, and data on the potential isoform-dependent therapeutic vulnerabilities are st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26aaf3a21c7123d8632c8ec31fa75511
http://hdl.handle.net/2318/1855101
http://hdl.handle.net/2318/1855101
Autor:
Pınar Özden, Eser, Raymond M, Paranal, Jieun, Son, Elena, Ivanova, Yanan, Kuang, Heidi M, Haikala, Ciric, To, Jeffrey J, Okoro, Kshiti H, Dholakia, Jihyun, Choi, Yoonji, Eum, Atsuko, Ogino, Pavlos, Missios, Dalia, Ercan, Man, Xu, Michael J, Poitras, Stephen, Wang, Kenneth, Ngo, Michael, Dills, Masahiko, Yanagita, Timothy, Lopez, Mika, Lin, Jeanelle, Tsai, Nicolas, Floch, Emily S, Chambers, Jennifer, Heng, Rana, Anjum, Alison D, Santucci, Kesi, Michael, Alwin G, Schuller, Darren, Cross, Paul D, Smith, Geoffrey R, Oxnard, David A, Barbie, Lynette M, Sholl, Magda, Bahcall, Sangeetha, Palakurthi, Prafulla C, Gokhale, Cloud P, Paweletz, George Q, Daley, Pasi A, Jänne
Publikováno v:
Science translational medicine
The clinical efficacy of epidermal growth factor receptor (EGFR)–targeted therapy in EGFR-mutant non–small cell lung cancer is limited by the development of drug resistance. One mechanism of EGFR inhibitor resistance occurs through amplification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22efb640067814269983395f20ecc3cd
https://pubmed.ncbi.nlm.nih.gov/34516823
https://pubmed.ncbi.nlm.nih.gov/34516823
Autor:
Emily S. Chambers, Alwin Schuller, Stephen Wang, Dalia Ercan, Mika Lin, Pınar Özden Eser, Raymond M. Paranal, Nicolas Floc'h, Sangeetha Palakurthi, Alison D. Santucci, Jeffrey J. Okoro, Geoffrey R. Oxnard, Man Xu, Kenneth H. Ngo, Jeanelle Tsai, Ciric To, Lynette M. Sholl, George Q. Daley, Michael Dills, Pavlos Missios, Kesi Michael, Paul D. Smith, Yoonji Eum, Magda Bahcall, Yanan Kuang, David A. Barbie, Masahiko Yanagita, Jennifer C. Heng, Rana Anjum, Prafulla C. Gokhale, Elena Ivanova, Jieun Son, Kshiti Dholakia, Heidi M. Haikala, Darren Cross, Jihyun Choi, Michael J. Poitras, Pasi A. Jänne, Timothy Lopez, Cloud P. Paweletz, Atsuko Ogino
Publikováno v:
Science Translational Medicine. 13
A subset of drug-resistant EGFR -mutant MET -amplified lung cancer switches oncogenic dependence to MET and is treatable with MET inhibitor monotherapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f7c7b3de9b86168add52ec03c24e84e
https://doi.org/10.1126/scitranslmed.abb3738
https://doi.org/10.1126/scitranslmed.abb3738
Autor:
Lianbo Li, Jeffrey J. Okoro, Chunya Lu, Kenneth D. Westover, Yibing Shan, Jonas N. Kapp, Chiara Ambrogio, Qi Wang, Pasi A. Jänne, Gabriela Nagy-Davidescu, Xiao Chen Bai, David E. Shaw, Zhi Wei Zhou, Venkatesh Mysore, Andreas Plückthun, Maxwell R. Tucker
Publikováno v:
Nat Struct Mol Biol
Nature Structural and Molecular Biology
Nature Structural and Molecular Biology
The protein K-Ras functions as a molecular switch in signaling pathways regulating cell growth. In the human mitogen-activated protein kinase (MAPK) pathway, which is implicated in many cancers, multiple K-Ras proteins are thought to assemble at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5db40503846144f720046370b99f9b
http://hdl.handle.net/2318/1816934
http://hdl.handle.net/2318/1816934
Autor:
Jeffrey J. Okoro, Chunya Lu, Maxwell R. Tucker, Kenneth D. Westover, Qi Wang, Lianbo Li, Pasi A. Jänne, Zhi Wei Zhou, Xiao Chen Bai, Yibing Shan, Andreas Plückthun, Chiara Ambrogio, Venkatesh Mysore, Gabriela Nagy-Davidescu, Jonas N. Kapp, David E. Shaw
The protein K-Ras functions as a molecular switch in signaling pathways regulating cell growth. In the MAPK pathway, which is implicated in many cancers, multiple K-Ras proteins are thought to assemble at the cell membrane with Ras-effector proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5322f3d4c5c84b7e3c1b9c9699ecfaa7
https://doi.org/10.1101/2020.07.15.165266
https://doi.org/10.1101/2020.07.15.165266
Autor:
Zhi-Wei, Zhou, Chiara, Ambrogio, Asim K, Bera, Qing, Li, Xing-Xiao, Li, Lianbo, Li, Jieun, Son, Sudershan, Gondi, Jiaqi, Li, Emily, Campbell, Hua, Jin, Jeffrey J, Okoro, Cheng-Xiong, Xu, Pasi A, Janne, Kenneth D, Westover
Publikováno v:
Cancer research. 80(17)
Assembly of RAS molecules into complexes at the cell membrane is critical for RAS signaling. We previously showed that oncogenic KRAS codon 61 mutations increase its affinity for RAF, raising the possibility that KRAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d3998258f0e28daae6ad7291884b9878
https://pubmed.ncbi.nlm.nih.gov/32605999
https://pubmed.ncbi.nlm.nih.gov/32605999