Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jeffrey Hannah"'
Autor:
Pengbo Zhou, Selina Chen-Kiang, Malcolm A.S. Moore, David C. Dorn, Jeffrey Hannah, Xiangao Huang, Maurizio Di Liberto, Cynthia A. Boyson, Chenyi Yang
Supplementary Figure S1. Freshly isolated primary CD34+ AML cells maintain the proliferating activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d851cf8ade37279533c846f4a4a096
https://doi.org/10.1158/0008-5472.22406445.v1
https://doi.org/10.1158/0008-5472.22406445.v1
Autor:
Pengbo Zhou, Selina Chen-Kiang, Malcolm A.S. Moore, David C. Dorn, Jeffrey Hannah, Xiangao Huang, Maurizio Di Liberto, Cynthia A. Boyson, Chenyi Yang
Legend for Supplementary Figures S1-S2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453aa7cb7c3cd1b34dbf2d6479645eb3
https://doi.org/10.1158/0008-5472.22406448
https://doi.org/10.1158/0008-5472.22406448
Autor:
Pengbo Zhou, Selina Chen-Kiang, Malcolm A.S. Moore, David C. Dorn, Jeffrey Hannah, Xiangao Huang, Maurizio Di Liberto, Cynthia A. Boyson, Chenyi Yang
Cyclin-dependent kinase (CDK)4 and CDK6 are frequently overexpressed or hyperactivated in human cancers. Targeting CDK4/CDK6 in combination with cytotoxic killing therefore represents a rational approach to cancer therapy. By selective inhibition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::357aec628cb332e735f3cbc07a7a2810
https://doi.org/10.1158/0008-5472.c.6507078.v1
https://doi.org/10.1158/0008-5472.c.6507078.v1
Autor:
Pengbo Zhou, Jeffrey Hannah
Publikováno v:
Chinese Journal of Cancer
Cullin 4A (CUL4A) is an E3 ubiquitin ligase that directly affects DNA repair and cell cycle progression by targeting substrates including damage-specific DNA-binding protein 2 (DDB2), xeroderma pigmentosum complementation group C (XPC), chromatin lic
Autor:
Jeffrey Hannah, Pengbo Zhou
Publikováno v:
DNA Repair. 8:536-543
Eukaryotic cells repair ultraviolet light (UV)- and chemical carcinogen-induced DNA strand-distorting damage through the nucleotide excision repair (NER) pathway. Concurrent activation of the DNA damage checkpoints is also required to arrest the cell
Autor:
Jeffrey Hannah, Pengbo Zhou
There are many techniques that can be employed to control gene expression at the post-translational level. However, a novel system called SMASh (small molecule–assisted shutoff), which allows for chemically-induced degradation of target proteins, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3efc55a3a8c1dc84624267fe50ed5376
https://europepmc.org/articles/PMC5098903/
https://europepmc.org/articles/PMC5098903/
Autor:
Jeffrey Hannah, Pengbo Zhou
Publikováno v:
Gene. 573(1)
The cullin 4 subfamily of genes includes CUL4A and CUL4B, which share a mostly identical amino acid sequence aside from the elongated N-terminal region in CUL4B. Both act as scaffolding proteins for modular cullin RING ligase 4 (CRL4) complexes which
Autor:
Jeffrey Hannah, Pengbo Zhou
Publikováno v:
Cell Research. 21:1152-1154
Autor:
Timothy M. D'Alfonso, Yifang Liu, Pengbo Zhou, Zhengming Chen, Jeffrey Hannah, Sandra J. Shin
AimsTriple-negative breast cancer comprises a clinically aggressive group of invasive carcinomas. We examined a published gene expression screen of a panel of breast cancer cell lines to identify a potential triple-negative breast cancer-specific gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d60fe90de8fc5a5b82d482f7d915ba02
https://europepmc.org/articles/PMC4549806/
https://europepmc.org/articles/PMC4549806/
Autor:
Jianxuan Zhang, Liang Ma, Liren Liu, Sara B. Peters, Andrew Koff, Sharrell Lee, Jeffrey Hannah, Yue Zhang, Yan Yin, Pengbo Zhou
Publikováno v:
Molecular cell. 34(4)
It is intuitively obvious that the ability of a cell to repair DNA damage is saturable, either by limitation of enzymatic activities, the time allotted to achieve their function, or both. However, very little is known regarding the mechanisms that es