Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jeffrey H. Tidwell"'
Autor:
Jeffrey H. Tidwell, George Andrew Freeman, Marty St. Clair, Robert G. Ferris, Lee T. Schaller, Dean W. Selleseth, Steven A. Short, Jill R. Cowan, Lawrence R. Boone, Kurt Weaver, G B Roberts, Joseph H. Chan, Richard J. Hazen, Kelly R. Moniri, Karen Rene Romines
Publikováno v:
Antimicrobial Agents and Chemotherapy. 49:4046-4051
The compound GW678248 is a novel benzophenone nonnucleoside reverse transcriptase inhibitor (NNRTI). Preclinical assessment of GW678248 indicates that this compound potently inhibits wild-type (WT) and mutant human immunodeficiency virus type 1 (HIV-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4865655b25dbfbe07da6cb52e75ed9fb
https://doi.org/10.1128/aac.49.10.4046-4051.2005
https://doi.org/10.1128/aac.49.10.4046-4051.2005
Autor:
Jeffrey H Tidwell
Publikováno v:
Encyclopedia of Pharmaceutical Science and Technology, Fourth Edition ISBN: 9781841848204
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6ec66d606ca991dc61db3991a0f6a9c
https://doi.org/10.1081/e-ept4-120050320
https://doi.org/10.1081/e-ept4-120050320
Publikováno v:
Journal of the American Chemical Society. 116:11797-11810
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4a96ed9b8224ad951debf54b773f1fc
https://doi.org/10.1021/ja00105a021
https://doi.org/10.1021/ja00105a021
Publikováno v:
The Journal of Organic Chemistry. 59:7164-7168
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49b07ee62ccaea07d02e95b67b826975
https://doi.org/10.1021/jo00102a055
https://doi.org/10.1021/jo00102a055
Publikováno v:
ChemInform. 22
Of particular significances is the complete regioselectivity of the method and its utilization of readily available starting materials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::253e8d852618d35482dadd0ecab8a99e
https://doi.org/10.1002/chin.199136179
https://doi.org/10.1002/chin.199136179
Publikováno v:
ChemInform. 24
The spirocyclic 1,2,7,7a-tetrahydrocycloprop[1,2-c]indol-4-one subunit of CC-1065 and duocarmycin A, which comprises the common pharmacophore of the two antibiotics, has been efficiently synthesized in six steps from readily avaible starting material
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::684088c50baa0280dbb3c030d70abc25
https://doi.org/10.1002/chin.199314283
https://doi.org/10.1002/chin.199314283
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d936853f41e6f08169d0f8550cd2d368
https://doi.org/10.1002/chin.199522123
https://doi.org/10.1002/chin.199522123
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::421d880bdf1a41d2511d752a97b737d5
https://doi.org/10.1002/chin.199523116
https://doi.org/10.1002/chin.199523116
Autor:
Richard J. Hazen, George Andrew Freeman, Karen Rene Romines, Joseph H. Chan, Jill R. Cowan, Jeffrey H. Tidwell, Steven A. Short, Andrews Clarence Webster, Robert G. Ferris, Lee T. Schaller, David K. Stammers, Steve S. Gonzales, Lawrence R. Boone
Publikováno v:
J Med Chem. 49(2)
Despite the progress of the past two decades, there is still considerable need for safe, efficacious drugs that target human immunodeficiency virus (HIV). This is particularly true for the growing number of patients infected with virus resistant to c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405b85ab19f215dab48e2757a2d46a62
http://ora.ox.ac.uk/objects/uuid:3971cc78-77e5-4caf-ab76-51d0ac6e806d
http://ora.ox.ac.uk/objects/uuid:3971cc78-77e5-4caf-ab76-51d0ac6e806d
Autor:
George Andrew Freeman, Jill R. Cowan, Marty St. Clair, Karen Rene Romines, Robert J. Harvey, Lee T. Schaller, Robert G. Ferris, Steven A. Short, Lawrence R. Boone, Joseph H. Chan, Jeffrey H. Tidwell, Richard Hazen
Publikováno v:
Antimicrobial agents and chemotherapy. 49(11)
GW678248, a novel nonnucleoside reverse transcriptase inhibitor, has been evaluated for anti-human immunodeficiency virus activity in a variety of in vitro assays against laboratory strains and clinical isolates. When GW678248 was tested in combinati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeb82d8484dcb9799dc0729602a6161f
https://pubmed.ncbi.nlm.nih.gov/16251284
https://pubmed.ncbi.nlm.nih.gov/16251284