Zobrazeno 1 - 10 of 28 pro vyhledávání: '"Jeffrey H. Lin"'
1
Akademický článek
Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy in pancreatic ductal adenocarcinoma
Autor: Il-Kyu Kim, Mark S. Diamond, Salina Yuan, Samantha B. Kemp, Benjamin M. Kahn, Qinglan Li, Jeffrey H. Lin, Jinyang Li, Robert J. Norgard, Stacy K. Thomas, Maria Merolle, Takeshi Katsuda, John W. Tobias, Timour Baslan, Katerina Politi, Robert H. Vonderheide, Ben Z. Stanger
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Acquired resistance to immunotherapy remains a critical yet incompletely understood biological mechanism. Here, using a mouse model of pancreatic ductal adenocarcinoma (PDAC) to study tumor relapse following immunotherapy-induced responses,
Externí odkaz: https://doaj.org/article/96e408eb89f447649478a14b903b0f6a
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2
Akademický článek
The real-world insights on the use, safety, and outcome of immune-checkpoint inhibitors in underrepresented populations with lung cancer
Autor: Xiao Hu, Jeffrey H. Lin, Stacey Pan, Yana V. Salei, Susan K. Parsons
Publikováno v: Cancer Treatment and Research Communications, Vol 40, Iss , Pp 100833- (2024)
Background: The data on immune checkpoint inhibitors (ICI) use in lung cancer individuals generally underrepresented in clinical trials are limited. We aimed to examine the ICI access, safety, and outcome in these populations using real-world data. M
Externí odkaz: https://doaj.org/article/0ac80a89967d44749331bf0a892c109f
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3
Akademický článek
Type II alveolar cell MHCII improves respiratory viral disease outcomes while exhibiting limited antigen presentation
Autor: Sushila A. Toulmin, Chaitali Bhadiadra, Andrew J. Paris, Jeffrey H. Lin, Jeremy Katzen, Maria C. Basil, Edward E. Morrisey, G. Scott Worthen, Laurence C. Eisenlohr
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Type II alveolar cells play central roles in multiple aspects of lung biology. Here the authors show that type II alveolar cells also constitutively express MHCII, exhibit limited MHCII antigen presentation capacity, and are a component of the host r
Externí odkaz: https://doaj.org/article/e19c792b6eed4c79a384d45bab80f5de
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8
Data from Site-Dependent Immune Escape Due to Impaired Dendritic Cell Cross-Priming
Autor: Robert H. Vonderheide, Jeffrey H. Lin, Mark S. Diamond
T-cell recognition of tumor neoantigens is critical for cancer immune surveillance and the efficacy of immunotherapy. Tumors can evade host immunity by altering their antigenicity or orchestrating an immunosuppressive microenvironment, leading to out
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f1b2b2cfb1c8552148c458eeb6ebc55
https://doi.org/10.1158/2326-6066.c.6550629.v1
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