Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Jeffrey H. Hager"'
Publikováno v:
iScience, Vol 13, Iss , Pp 488-497 (2019)
Summary: Werner syndrome protein (WRN) is a RecQ enzyme involved in the maintenance of genome integrity. Germline loss-of-function mutations in WRN led to premature aging and predisposition to cancer. We evaluated synthetic lethal (SL) interactions b
Externí odkaz:
https://doaj.org/article/bb89d1e0545341388d7cc3f633d07161
Autor:
James D Joseph, Beatrice Darimont, Wei Zhou, Alfonso Arrazate, Amy Young, Ellen Ingalla, Kimberly Walter, Robert A Blake, Jim Nonomiya, Zhengyu Guan, Lorna Kategaya, Steven P Govek, Andiliy G Lai, Mehmet Kahraman, Dan Brigham, John Sensintaffar, Nhin Lu, Gang Shao, Jing Qian, Kate Grillot, Michael Moon, Rene Prudente, Eric Bischoff, Kyoung-Jin Lee, Celine Bonnefous, Karensa L Douglas, Jackaline D Julien, Johnny Y Nagasawa, Anna Aparicio, Josh Kaufman, Benjamin Haley, Jennifer M Giltnane, Ingrid E Wertz, Mark R Lackner, Michelle A Nannini, Deepak Sampath, Luis Schwarz, Henry Charles Manning, Mohammed Noor Tantawy, Carlos L Arteaga, Richard A Heyman, Peter J Rix, Lori Friedman, Nicholas D Smith, Ciara Metcalfe, Jeffrey H Hager
Publikováno v:
eLife, Vol 8 (2019)
Externí odkaz:
https://doaj.org/article/d1935c5b03e6433ea06acf491e7dc6f2
Autor:
Jeffrey H. Hager, Beatrice Darimont, Isan Chen, Edna Chow Maneval, Michael Moon, Dan Brigham, Gang Shao, John Sensintaffar, Jing Qian, Nhin Lu, James D. Joseph
PDF file - 183K, Supplementary Table S1. 1st and 2nd generation AR antagonist activity on F876L-AR. Supplementary Table S2. LNCaP/SRF876L Xenograft Pharmacokinetics Supplementary Table S3. AR nucleotide changes monitored by BEAMing assay Supplemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f2e79c45774b04e048841baece0c01
https://doi.org/10.1158/2159-8290.22530719
https://doi.org/10.1158/2159-8290.22530719
Autor:
Jeffrey H. Hager, Beatrice Darimont, Isan Chen, Edna Chow Maneval, Michael Moon, Dan Brigham, Gang Shao, John Sensintaffar, Jing Qian, Nhin Lu, James D. Joseph
PDF file - 401K, Supplementary Figure S1. Parental and 2nd generation anti-androgen resistant cell line proliferation. Supplementary Figure S2. AR levels in parental and 2nd generation anti-androgen resistant cell lines. Supplementary Figure S3. AR l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba5f8f0deb91bd874dc4fd74d291586
https://doi.org/10.1158/2159-8290.22530722.v1
https://doi.org/10.1158/2159-8290.22530722.v1
Autor:
Jeffrey H. Hager, Nicholas D. Smith, Tadimeti S. Rao, Stewart A. Noble, Andrew K. Shiau, Jerry Muhammad, Robert L. Davis, James W. Malecha, Alan Saven, Brandon M. Wiley, Sara J. Dozier, Timothy Z. Hoffman, Elena L. Milkova, John V. Anzola, Yan Wang, Carol Trotter, Céline Bonnefous, David A. Jenkins, Joseph E. Payne, Paul L. Wash, Tami Annable, Phan-Manh Nguyen, Xin Guo, Kent T. Symons, Christian A. Hassig
Supplementary Fig. S1 from KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0239cd0b9e59719d73ad9a95a451c7a2
https://doi.org/10.1158/1535-7163.22485309
https://doi.org/10.1158/1535-7163.22485309
Autor:
Jeffrey H. Hager, Nicholas D. Smith, Tadimeti S. Rao, Stewart A. Noble, Andrew K. Shiau, Jerry Muhammad, Robert L. Davis, James W. Malecha, Alan Saven, Brandon M. Wiley, Sara J. Dozier, Timothy Z. Hoffman, Elena L. Milkova, John V. Anzola, Yan Wang, Carol Trotter, Céline Bonnefous, David A. Jenkins, Joseph E. Payne, Paul L. Wash, Tami Annable, Phan-Manh Nguyen, Xin Guo, Kent T. Symons, Christian A. Hassig
Supplementary Table S1 from KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad2d0b912497ade790e8191dc8a1a6a
https://doi.org/10.1158/1535-7163.22485300
https://doi.org/10.1158/1535-7163.22485300
Autor:
Jeffrey H. Hager, Nicholas D. Smith, Tadimeti S. Rao, Stewart A. Noble, Andrew K. Shiau, Jerry Muhammad, Robert L. Davis, James W. Malecha, Alan Saven, Brandon M. Wiley, Sara J. Dozier, Timothy Z. Hoffman, Elena L. Milkova, John V. Anzola, Yan Wang, Carol Trotter, Céline Bonnefous, David A. Jenkins, Joseph E. Payne, Paul L. Wash, Tami Annable, Phan-Manh Nguyen, Xin Guo, Kent T. Symons, Christian A. Hassig
Supplementary Methods from KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14bc54c95af4c3db718bbfdaab0ab55
https://doi.org/10.1158/1535-7163.22485303.v1
https://doi.org/10.1158/1535-7163.22485303.v1
Autor:
Jeffrey H. Hager, Nicholas D. Smith, Tadimeti S. Rao, Stewart A. Noble, Andrew K. Shiau, Jerry Muhammad, Robert L. Davis, James W. Malecha, Alan Saven, Brandon M. Wiley, Sara J. Dozier, Timothy Z. Hoffman, Elena L. Milkova, John V. Anzola, Yan Wang, Carol Trotter, Céline Bonnefous, David A. Jenkins, Joseph E. Payne, Paul L. Wash, Tami Annable, Phan-Manh Nguyen, Xin Guo, Kent T. Symons, Christian A. Hassig
Histone deacetylase (HDAC) inhibitors have garnered significant attention as cancer drugs. These therapeutic agents have recently been clinically validated with the market approval of vorinostat (SAHA, Zolinza) for treatment of cutaneous T-cell lymph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1f183e54b1bbd2454f1a4fe5e3e9de
https://doi.org/10.1158/1535-7163.c.6531885.v1
https://doi.org/10.1158/1535-7163.c.6531885.v1
Autor:
Jeffrey H. Hager, Charles L. Sawyers, Michael E. Jung, Richard A. Heyman, Peter J. Rix, Ouathek Ouerfelli, Nian Wu, Elisa De Stanchina, Nicholas D. Smith, Mark Klang, Peter Smith-Jones, Howard I. Scher, Beatrice Darimont, Celine Bonnefous, Mark R. Herbert, Teresa Wasielewska, John Sensintaffar, Chunyan Cao, Guangbin Yang, Hong Zhao, Jing Qian, Gang Shao, Vivek Arora, Steven Dorow, Anna Aparicio, Ling Cai, Eric D. Bischoff, Kate Grillot, Yu Chen, Anna Dilhas, Samedy Ouk, Chris Tran, James D. Joseph, John Wongvipat, Nicola J. Clegg
PDF file - 185K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0f57c8b6ecb96bc53146deeb63d113
https://doi.org/10.1158/0008-5472.22393724.v1
https://doi.org/10.1158/0008-5472.22393724.v1
Autor:
Jeffrey H. Hager, Charles L. Sawyers, Michael E. Jung, Richard A. Heyman, Peter J. Rix, Ouathek Ouerfelli, Nian Wu, Elisa De Stanchina, Nicholas D. Smith, Mark Klang, Peter Smith-Jones, Howard I. Scher, Beatrice Darimont, Celine Bonnefous, Mark R. Herbert, Teresa Wasielewska, John Sensintaffar, Chunyan Cao, Guangbin Yang, Hong Zhao, Jing Qian, Gang Shao, Vivek Arora, Steven Dorow, Anna Aparicio, Ling Cai, Eric D. Bischoff, Kate Grillot, Yu Chen, Anna Dilhas, Samedy Ouk, Chris Tran, James D. Joseph, John Wongvipat, Nicola J. Clegg
PDF file - 181K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a9d43c3d094fe2a4e4d08a204389238
https://doi.org/10.1158/0008-5472.22393718
https://doi.org/10.1158/0008-5472.22393718