Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Jeffrey H. Epstein-Toney"'
Autor:
James V. Heck, John W. Kozarich, Lynn L. Silver, Joyce Kohler, R Thompson, Charles Gill, Frank P. DiNinno, Joann Huber, Hugh Rosen, Robert R. Wilkening, Jeffrey H. Epstein-Toney, Jon G. Sundelof, Barbara A. Pelak, Karen Dorso, Richard Hajdu, Gail G. Hammond, Kenneth J. Wildonger, Helmut Kropp, Timothy A. Blizzard, Jesse J. Jackson, Ronald W. Ratcliffe, Milton L. Hammond, George R. Lankas
Publikováno v:
Science. 283:703-706
A carbapenem antibiotic, L-786,392, was designed so that the side chain that provides high-affinity binding to the penicillin-binding proteins responsible for bacterial resistance was also the structural basis for ameliorating immunopathology. Expuls
Autor:
James M. Balkovec, Gail G. Hammond, Joanne B. Laub, David L. Pompliano, Jeffrey H. Epstein-Toney, Mark L. Greenlee, Milton L. Hammond
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(17)
Potent thioester and thiol inhibitors of IMP-1 metallo-beta-lactamase have been synthesized employing a solid-phase Mitsunobu reaction as the key step.