Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Jeffrey H Ruth"'
Autor:
Sadiq Umar, Anil K. Singh, Mukesh Chourasia, Stephanie M. Rasmussen, Jeffrey H. Ruth, Salahuddin Ahmed
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
O-GlcNAcylation is a reversible post-translational modification that regulates numerous cellular processes, including embryonic development as well as immune responses. However, its role in inflammation remains ambiguous. This study was designed to e
Externí odkaz:
https://doaj.org/article/f0b7ab4a371e402b91914c7241a45adc
Autor:
Pei-Suen Tsou, Chenyang Lu, Mikel Gurrea-Rubio, Sei Muraoka, Phillip L. Campbell, Qi Wu, Ellen N. Model, Matthew E. Lind, Sirapa Vichaikul, Megan N. Mattichak, William D. Brodie, Jonatan L. Hervoso, Sarah Ory, Camila I. Amarista, Rida Pervez, Lucas Junginger, Mustafa Ali, Gal Hodish, Morgan M. O’Mara, Jeffrey H. Ruth, Aaron M. Robida, Andrew J. Alt, Chengxin Zhang, Andrew G. Urquhart, Jeffrey N. Lawton, Kevin C. Chung, Tristan Maerz, Thomas L. Saunders, Vincent E. Groppi, David A. Fox, M. Asif Amin
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 11 (2022)
CD13, an ectoenzyme on myeloid and stromal cells, also circulates as a shed, soluble protein (sCD13) with powerful chemoattractant, angiogenic, and arthritogenic properties, which require engagement of a G protein–coupled receptor (GPCR). Here we i
Externí odkaz:
https://doaj.org/article/e5e9835fa1944ab4a428208a7bd7d3dd
Autor:
Sirapa Vichaikul, Mikel Gurrea-Rubio, M. Asif Amin, Phillip L. Campbell, Qi Wu, Megan N. Mattichak, William D. Brodie, Pamela J. Palisoc, Mustafa Ali, Sei Muraoka, Jeffrey H. Ruth, Ellen N. Model, Dallas M. Rohraff, Jonatan L. Hervoso, Yang Mao-Draayer, David A. Fox, Dinesh Khanna, Amr H. Sawalha, Pei-Suen Tsou
Publikováno v:
JCI Insight, Vol 7, Iss 9 (2022)
Binding of the bromodomain and extraterminal domain proteins (BETs) to acetylated histone residues is critical for gene transcription. We sought to determine the antifibrotic efficacy and potential mechanisms of BET inhibition in systemic sclerosis (
Externí odkaz:
https://doaj.org/article/144c5e7d2e6a41519ccf4095bccbb0c0
Autor:
Jeffrey H. Ruth, Mikel Gurrea-Rubio, Kalana S. Athukorala, Stephanie M. Rasmussen, Daniel P. Weber, Peggy M. Randon, Rosemary J. Gedert, Matthew E. Lind, M. Asif Amin, Phillip L. Campbell, Pei-Suen Tsou, Yang Mao-Draayer, Qi Wu, Thomas M. Lanigan, Venkateshwar G. Keshamouni, Nora G. Singer, Feng Lin, David A. Fox
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Limitations of checkpoint inhibitor cancer immunotherapy include induction of autoimmune syndromes and resistance of many cancers. Since CD318, a novel CD6 ligand, is associated with the aggressiveness and metastatic potential of human cancers, we te
Externí odkaz:
https://doaj.org/article/f287e4446e9b405d899bf9971cadfab5
Autor:
Martin J. O’Brien, Qiang Shu, W.Alexander Stinson, Pei-Suen Tsou, Jeffrey H. Ruth, Takeo Isozaki, Phillip L. Campbell, Ray A. Ohara, Alisa E. Koch, David A. Fox, M. Asif Amin
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-8 (2018)
Abstract Background Galectin-9 (Gal-9) is a mammalian lectin secreted by endothelial cells that is highly expressed in rheumatoid arthritis synovial tissues and synovial fluid. Roles have been proposed for galectins in the regulation of inflammation
Externí odkaz:
https://doaj.org/article/4f63b3bffec345f58497e6ec184a9263
Mammalian Glycosylation Patterns Protect Citrullinated Chemokine MCP-1/CCL2 from Partial Degradation
Autor:
Olexandr Korchynskyi, Ken Yoshida, Nataliia Korchynska, Justyna Czarnik-Kwaśniak, Paul P. Tak, Ger J. M. Pruijn, Takeo Isozaki, Jeffrey H. Ruth, Phillip L. Campbell, M. Asif Amin, Alisa E. Koch
Publikováno v:
International Journal of Molecular Sciences, 24, 1-12
International Journal of Molecular Sciences, 24, 3, pp. 1-12
International Journal of Molecular Sciences; Volume 24; Issue 3; Pages: 1862
International Journal of Molecular Sciences, 24, 3, pp. 1-12
International Journal of Molecular Sciences; Volume 24; Issue 3; Pages: 1862
Peer reviewed: True
Monocyte chemoattractant protein-1 (MCP-1/CCL2) is a potent chemotactic agent for monocytes, primarily produced by macrophages and endothelial cells. Significantly elevated levels of MCP-1/CCL2 were found in synovial fluids o
Monocyte chemoattractant protein-1 (MCP-1/CCL2) is a potent chemotactic agent for monocytes, primarily produced by macrophages and endothelial cells. Significantly elevated levels of MCP-1/CCL2 were found in synovial fluids o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2149a315ca1c9dd87629887791881d45
http://hdl.handle.net/2066/290354
http://hdl.handle.net/2066/290354
Autor:
M. Asif Amin, Feng Lin, Nora G. Singer, David A. Fox, Phillip L. Campbell, Stephanie M. Rasmussen, Daniel P. Weber, Kalana S. Athukorala, Yan Li, Jeffrey H. Ruth
Publikováno v:
Arthritis Rheumatol
OBJECTIVE CD6 is an important regulator of T cell function that interacts with the ligands CD166 and CD318. To further clarify the significance of CD6 in rheumatoid arthritis (RA), we examined the effects of targeting CD6 in the mouse model of collag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3d32d744ad34510bfde245cf281098
https://doi.org/10.1002/art.41288
https://doi.org/10.1002/art.41288
Autor:
Henriette A. Remmer, Ray A. Ohara, Stephanie M. Rasmussen, Phillip L. Campbell, Thomas M. Lanigan, Jeffrey H. Ruth, Takeo Isozaki, David A. Fox, Kevin C. Chung, Gautam Edhayan, Andrew G. Urquhart, Jeffrey N. Lawton
Publikováno v:
Arthritis & Rheumatology (Hoboken, N.j.)
Objective To explore the intrinsic role of inhibitor of DNA binding 1 (ID‐1) in rheumatoid arthritis (RA) fibroblast‐like synoviocytes (FLS) and to investigate whether ID‐1 is citrullinated and autoantigenic in RA. Methods RA patient serum ID
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d130ed335625b7fb39b543e6bda12635
https://doi.org/10.1002/art.40886
https://doi.org/10.1002/art.40886
Autor:
Pei-Suen Tsou, Chenyang Lu, Mikel Gurrea-Rubio, Sei Muraoka, Phillip L. Campbell, Qi Wu, Ellen N. Model, Matthew E. Lind, Sirapa Vichaikul, Megan N. Mattichak, William D. Brodie, Jonatan L. Hervoso, Sarah Ory, Camila I. Amarista, Rida Pervez, Lucas Junginger, Mustafa Ali, Gal Hodish, Morgan M. O’Mara, Jeffrey H. Ruth, Aaron M. Robida, Andrew J. Alt, Chengxin Zhang, Andrew G. Urquhart, Jeffrey N. Lawton, Kevin C. Chung, Tristan Maerz, Thomas L. Saunders, Vincent E. Groppi, David A. Fox, M. Asif Amin
Publikováno v:
The Journal of clinical investigation. 132(11)
CD13, an ectoenzyme on myeloid and stromal cells, also circulates as a shed, soluble protein (sCD13) with powerful chemoattractant, angiogenic, and arthritogenic properties, which require engagement of a G protein-coupled receptor (GPCR). Here we ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12fa2bd96bf8fc5dc68d3c8e3d23978e
https://pubmed.ncbi.nlm.nih.gov/35545682
https://pubmed.ncbi.nlm.nih.gov/35545682
Autor:
Sirapa Vichaikul, Mikel Gurrea-Rubio, M. Asif Amin, Phillip L. Campbell, Qi Wu, Megan N. Mattichak, William D. Brodie, Pamela J. Palisoc, Mustafa Ali, Sei Muraoka, Jeffrey H. Ruth, Ellen N. Model, Dallas M. Rohraff, Jonatan L. Hervoso, Yang Mao-Draayer, David A. Fox, Dinesh Khanna, Amr H. Sawalha, Pei-Suen Tsou
Publikováno v:
JCI insight. 7(9)
Binding of the bromodomain and extraterminal domain proteins (BETs) to acetylated histone residues is critical for gene transcription. We sought to determine the antifibrotic efficacy and potential mechanisms of BET inhibition in systemic sclerosis (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2727b613a0d32eb92f4ad3c2bb91ce9
https://pubmed.ncbi.nlm.nih.gov/35349485
https://pubmed.ncbi.nlm.nih.gov/35349485