Výsledky vyhledávání - "Jeffrey H Hanke"

Selective targeting of the IL23 pathway: Generation and characterization of a novel high-affinity humanized anti-IL23A antibody

Autor: David Presky, Ernest L. Raymond, Catron Katrina Mary, Jeffrey H Hanke, Keith Canada, Lee Frego, Laura Amodeo, Jennifer Ahlberg, Eliud Sepulveda, Rachel Kroe-Barrett, Xiang Zhu, Helen Wu, Yaqin He, Sanjaya Singh

Publikováno v: mAbs

Herein, we describe the generation and characterization of BI 655066, a novel, highly potent neutralizing anti-interleukin-23 (IL23) monoclonal antibody in clinical development for autoimmune conditions, including psoriasis and Crohn's disease. IL23

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c237c2e09bbb003edca42bf1903c800
https://pubmed.ncbi.nlm.nih.gov/25905918

Zobrazit plný text záznamu

Targeted therapies for cancer – from tamoxifen to gefitinib (‘Iressa’)

Autor: Les R. Hughes, Jeffrey H. Hanke

Publikováno v: Drug Discovery Today: Therapeutic Strategies. 1:411-416

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::246c979792021687e099b07ec885f89d
https://doi.org/10.1016/j.ddstr.2004.11.002

Zobrazit plný text záznamu

Molecular characterization of a subtype of DQw1 recognized by hapten-specific T cells

Autor: Joseph W. Leone, Richard G. Cook, Jeffrey H. Hanke, Robert R. Rich, Mai Van

Publikováno v: Immunogenetics. 24:209-216

Previous studies of HLA-restricted antigen recognition by cloned T cells have frequently demonstrated reactivity that did not correlate precisely with the expression of serologically defined HLA specificities. To further explore such discrepancies, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c58597475af1424a23b4471aecb693b0
https://doi.org/10.1007/bf00364524

Zobrazit plný text záznamu

Trinitrophenyl Reactive T-Cell Clones in Functional and Molecular Analysis of the HLA-D Region

Autor: Richard G. Cook, Robert R. Rich, Jeffrey H. Hanke

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9781468454444

A central role for major histocompatibility complex (MHC) molecules in presentation of non-MHC antigens to T lymphocytes is generally acknowledged. Among the seminal studies demonstrating this phenomenon were those of Shearer and associates demonstra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b529715f54981ed3ff3f82f3cc1c2b2b
https://doi.org/10.1007/978-1-4684-5442-0_4

Zobrazit plný text záznamu

Class II positive human dermal fibroblasts restimulate cloned allospecific T cells but fail to stimulate primary allogeneic lymphoproliferation

Autor: Mai Van, Marilyn S. Pollack, Robert R. Rich, Weldon E. Collins, David H. Maurer, Jeffrey H. Hanke

Publikováno v: Human immunology. 14(3)

Recently, a number of laboratories have shown that gamma interferon (IFN-γ) is a potent modulator of HLA class II antigen expression in a variety of cell types ranging from classical antigen presenting cells to those not expected to participate in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a1b4e3b4275a6b1e87916cff554dce
https://pubmed.ncbi.nlm.nih.gov/3932267

Zobrazit plný text záznamu

Identification of Murine Nuclear Proteins that Bind to the Octamer Control Sequence of Immunoglobulin Genes using 5’-Amino-Oligonucleotides

Autor: Jeffrey H. Hanke, Philip W. Tucker, J. Donald Capra

Publikováno v: Methods in Protein Sequence Analysis ISBN: 9783642738364

The identification and characterization of proteins that bind to regulatory DNA sequences in the promoters of genes is key to a clear understanding of how their expression is controlled. The octameric sequence ATTTGCAT represents an important regulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07fa588f6fbbd06bc6b8121ac7a1b4de
https://doi.org/10.1007/978-3-642-73834-0_61

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání