Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jeffrey Gerwin"'
Autor:
Daniel E. Tylawsky, Hiroto Kiguchi, Jake Vaynshteyn, Jeffrey Gerwin, Janki Shah, Taseen Islam, Jacob A. Boyer, Daniel R. Boué, Matija Snuderl, Matthew B. Greenblatt, Yosi Shamay, G. Praveen Raju, Daniel A. Heller
Publikováno v:
Nature Materials. 22:391-399
Medulloblastoma is the most common malignant paediatric brain tumour, with ~30% mediated by Sonic hedgehog signalling. Vismodegib-mediated inhibition of the Sonic hedgehog effector Smoothened inhibits tumour growth but causes growth plate fusion at e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc1d70af9c05cc7c2ec3b92c55ca03fc
https://doi.org/10.1038/s41563-023-01481-9
https://doi.org/10.1038/s41563-023-01481-9
Autor:
Ross Keller, Makiko Yamada, Daniel Cameron, Hiromichi Suzuki, Reeti Sanghrajka, Jake Vaynshteyn, Jeffrey Gerwin, Francesco Maura, William Hooper, Minita Shah, Nicolas Robine, Philip Demarest, N. Sumru Bayin, Luz Jubierre, Casie Reed, Michael D. Taylor, Alexandra L. Joyner, G. Praveen Raju, Alex Kentsis
Genomic rearrangements are a hallmark of most solid tumors, including medulloblastoma, one of the most common brain tumors in children. Childhood cancers involve dysregulated cell development, but their mutational causes remain largely unknown. One o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5f402393cd72cef69bf54a7c55ad609
https://doi.org/10.1101/2022.07.05.498128
https://doi.org/10.1101/2022.07.05.498128
Autor:
Yosi Shamay, Matthew B. Greenblatt, Praveen Raju, Taseen Islam, Jeffrey Gerwin, Jake Vaynshteyn, Hiro Kiguchi, Daniel Tylawsky, Daniel R. Boue, Janki Shah, Matija Snuderl, Daniel A. Heller
Medulloblastoma (MB) is the most common malignant pediatric brain tumor with ~30% mediated by Sonic hedgehog (SHH) signaling. While SHH effector Smoothened inhibition is promising, therapeutic index is reduced by high systemic doses required for suff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcb603f620ffe31aff75535bddfa1335
https://doi.org/10.21203/rs.3.rs-658944/v1
https://doi.org/10.21203/rs.3.rs-658944/v1
Autor:
Praveen Raju, Daniel Tylawsky, Jake Vaynshteyn, Jeffrey Gerwin, Daniel Heller, Matija Snuderl
Publikováno v:
Neuro-Oncology. 24:i126-i126
The histone-lysine N-methyltransferase EZH2 is the catalytic component of the PRC2 complex and is overexpressed in several medulloblastoma subtypes. However, its role in medulloblastoma tumorigenesis has been shown to be context-dependent using genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5e7394d763228d2de23329978edb9b5
https://doi.org/10.1093/neuonc/noac079.457
https://doi.org/10.1093/neuonc/noac079.457
Autor:
Hiroto Kiguchi, Mandana Manzari, Jake Vaynshteyn, Jeffrey Gerwin, Daniel Tylawsky, Na Li, Janki Shah, Yosi Shamay, Matthew Greenblatt, Daniel Heller, G Praveen Raju
Publikováno v:
Neuro Oncol
OBJECTIVE The Sonic Hedgehog (SHH) medulloblastoma subgroup accounts for ~25% of all cases and has an intermediate prognosis. Current conventional therapies result in devastating morbidities including intellectual disability and secondary malignancie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c875c5984b4aa4bca157751c857ed738
https://europepmc.org/articles/PMC6846632/
https://europepmc.org/articles/PMC6846632/
Autor:
Daniel A. Heller, Matthew B. Greenblatt, Daniel Tylawsky, Jeffrey Gerwin, Na Li, Praveen Raju, Janki Shah, Hiro Kiguchi, Jake Vaynshteyn, Mandana T. Manzari, Yosi Shamay
Publikováno v:
Neuro-Oncology
OBJECTIVE The Sonic Hedgehog (SHH) medulloblastoma subgroup accounts for ~25% of all cases and has an intermediate prognosis. Current therapies result in devastating morbidities including intellectual disability and secondary malignancies. Although m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930b65c417ff51ec917b65101f5f0439
https://doi.org/10.1093/neuonc/noaa222.050
https://doi.org/10.1093/neuonc/noaa222.050