Výsledky vyhledávání - "Jeffrey G. A. Walton"

Fluorescent Formazans and Tetrazolium Salts - Towards Fluorescent Cytotoxicity Assays

Autor: Mark Bradley, Annamaria Lilienkampf, Jeffrey G. A. Walton, Melissa Ladyman

Publikováno v: Ladyman, M K, Walton, J G A, Lilienkampf, A & Bradley, M 2016, ' Fluorescent Formazans and Tetrazolium Salts-Towards Fluorescent Cytotoxicity Assays ', Combinatorial Chemistry and High Throughput Screening, vol. 19, no. 5, pp. 384-391 . https://doi.org/10.2174/1386207319666160408150913

Published in Combinatorial Chemistry and High Throughput Screening 2016, vol 19 part 5 pp 384-391
Formazan-based colorimetric cytotoxicity assays, such as the MTT assay, are typically used to assess cell viability with only metabolically active

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b6b6525443945ba2124ba0461b257e
https://doi.org/10.2174/1386207319666160408150913

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Peptides for cell-selective drug delivery

Autor: Jeffrey G. A. Walton, Nina Svensen, Mark Bradley

Publikováno v: Trends in Pharmacological Sciences. 33:186-192

The ability to target specific cell types to achieve optimal distribution of therapeutic entities into diseased tissues, while limiting possible adverse off-target effects, has long been a goal of many research groups and pharmaceutical organizations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf3081798c8797205f733920a4ee62b
https://doi.org/10.1016/j.tips.2012.02.002

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Click chemistry generated model DNA-peptide heteroconjugates as tools for mass spectrometry

Autor: Fiona J Flett, Jeffrey G. A. Walton, C. Logan Mackay, Heidrun Interthal

Publikováno v: Analytical chemistry. 87(19)

UV cross-linking of nucleic acids to proteins in combination with mass spectrometry is a powerful technique to identify proteins, peptides, and the amino acids involved in intermolecular interactions within nucleic acid-protein complexes. However, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6c567170f8e9043fcf84fa9333fb0a
https://pubmed.ncbi.nlm.nih.gov/26335278

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Synthesis and lyotropic phase behavior of novel nonionic surfactants for the crystallization of integral membrane proteins

Autor: Gordon J. T. Tiddy, Jeffrey G. A. Walton, Simon J. Webb

Publikováno v: Tetrahedron Letters. 47:737-741

A series of new sugar-based nonionic surfactants have been synthesized and their lyotropic liquid crystalline properties characterized. When in contact with water, these surfactants formed a range of lyotropic liquid crystalline phases, including cub

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https://doi.org/10.1016/j.tetlet.2005.11.103

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Stabilizing hepatocellular phenotype using optimized synthetic surfaces

Autor: Paul J. Travers, David C. Hay, Mark Bradley, John P. Iredale, Dagmara Szkolnicka, Ferdous Khan, Baltasar Lucendo-Villarin, Jeffrey G. A. Walton, Katherine Cameron

Publikováno v: Journal of visualized experiments : JoVE. (91)

Currently, one of the major limitations in cell biology is maintaining differentiated cell phenotype. Biological matrices are commonly used for culturing and maintaining primary and pluripotent stem cell derived hepatocytes. While biological matrices

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec8f14ffca0c1b4205849b481a25f22
https://pubmed.ncbi.nlm.nih.gov/25285607

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Photoluminescent carbon dots from 1,4-addition polymers

Autor: Rong Zhang, Andrew Nolan, Jeffrey G. A. Walton, Zhiqiang Jiang, Mark Bradley, Annamaria Lilienkampf

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 20(35)

Photoluminescent carbon dots were synthesised directly by thermopyrolysis of 1,4-addition polymers, allowing precise control of their properties. The effect of polymer composition on the properties of the carbon dots was investigated by TEM, IR, XPS,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6e328eab916a02e10fdbc75983b118a
https://pubmed.ncbi.nlm.nih.gov/25099331

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A fluorescein-derived anthocyanidin-inspired pH sensor

Autor: Jeffrey G. A. Walton, Patricia R. Richardson, Asier Unciti-Broceta, M. Rahimi Yusop, Mark Bradley

Publikováno v: Tetrahedron Letters. 50:3713-3715

A new multicolor pH-dependent fluorophore was synthesized via Pd-mediated cross-coupling chemistry of the mono-triflate of fluorescein with p-hydroxyphenylboronic acid. The novel indicator, named anthofluorescein, is highly sensitive to pH changes be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::065c8e99844d982fdf9e1300585b934a
https://doi.org/10.1016/j.tetlet.2009.03.223

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Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase

Autor: Deuan C. Jones, Jeffrey G. A. Walton, Alastair J. Durie, Alan H. Fairlamb, Paula Kiuru, Nicholas J. Westwood

Publikováno v: Walton, J G A, Jones, D C, Kiuru, P, Durie, A J, Westwood, N J & Fairlamb, A H 2011, ' Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase ', ChemMedChem, vol. 6, no. 2, pp. 321-328 . https://doi.org/10.1002/cmdc.201000442
University of Helsinki
Chemmedchem

The search for novel compounds of relevance to the treatment of diseases caused by trypanosomatid protozoan parasites continues. Screening of a large library of known bioactive compounds has led to several drug-like starting points for further optimi

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https://hdl.handle.net/20.500.11820/d0308739-ac90-4817-9c34-6a389159a97b

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