Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Jeffrey Fillingham"'
Autor:
Syed Nabeel-Shah, Jyoti Garg, Kanwal Ashraf, Renu Jeyapala, Hyunmin Lee, Alexandra Petrova, James D. Burns, Shuye Pu, Zhaolei Zhang, Jack F. Greenblatt, Ronald E. Pearlman, Jean-Philippe Lambert, Jeffrey Fillingham
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-22 (2023)
Abstract Background Eukaryotic cells can rapidly adjust their transcriptional profile in response to molecular needs. Such dynamic regulation is, in part, achieved through epigenetic modifications and selective incorporation of histone variants into
Externí odkaz:
https://doaj.org/article/e4f36e6d55c941bfb45b7fa551f9ce48
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-17 (2019)
Abstract Background Chromatin immunoprecipitation coupled to next generation sequencing (ChIP-Seq) is a widely-used molecular method to investigate the function of chromatin-related proteins by identifying their associated DNA sequences on a genomic
Externí odkaz:
https://doaj.org/article/eceafd6ca4fc4ac191dac36ec20fd518
Autor:
Syed Nabeel-Shah, Jyoti Garg, Pata-Eting Kougnassoukou Tchara, Ronald E. Pearlman, Jean-Philippe Lambert, Jeffrey Fillingham
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100362- (2021)
Summary: We describe an optimized protocol for one-step affinity purification of FZZ-tagged proteins followed by mass spectrometry analysis for the identification of protein-protein interactions in the ciliate protozoan Tetrahymena thermophila. The F
Externí odkaz:
https://doaj.org/article/4286ef92df364718915a1b61ea21a98f
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The eukaryotic histone acetylation cycle is composed of three classes of proteins, histone acetyltransferases (HATs) that add acetyl groups to lysine amino acids, bromodomain (BRD) containing proteins that are one of the most characterized of several
Externí odkaz:
https://doaj.org/article/167a81b6d5314c9685ecdeb61507b520
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 6, Pp 1993-2006 (2018)
The Hif1 protein in the yeast Saccharomyces cerevisie is an evolutionarily conserved H3/H4-specific chaperone and a subunit of the nuclear Hat1 complex that catalyzes the acetylation of newly synthesized histone H4. Hif1, as well as its human homolog
Externí odkaz:
https://doaj.org/article/9f316cfcbfa944e9908efc9e949c324a
Autor:
Alejandro Saettone, Jyoti Garg, Jean-Philippe Lambert, Syed Nabeel-Shah, Marcelo Ponce, Alyson Burtch, Cristina Thuppu Mudalige, Anne-Claude Gingras, Ronald E. Pearlman, Jeffrey Fillingham
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-20 (2018)
Abstract Background The chromatin remodelers of the SWI/SNF family are critical transcriptional regulators. Recognition of lysine acetylation through a bromodomain (BRD) component is key to SWI/SNF function; in most eukaryotes, this function is attri
Externí odkaz:
https://doaj.org/article/56375229106346adae0c58fc7d881d4c
Autor:
Alejandro Saettone, Syed Nabeel-Shah, Jyoti Garg, Jean-Philippe Lambert, Ronald E. Pearlman, Jeffrey Fillingham
Publikováno v:
Genes, Vol 10, Iss 5, p 333 (2019)
Identification and characterization of protein complexes and interactomes has been essential to the understanding of fundamental nuclear processes including transcription, replication, recombination, and maintenance of genome stability. Despite signi
Externí odkaz:
https://doaj.org/article/f8f6dba0eab04b31be25f3049719624e
Autor:
Jean‐Philippe Lambert, Jeffrey Fillingham, Mojgan Siahbazi, Jack Greenblatt, Kristin Baetz, Daniel Figeys
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp n/a-n/a (2010)
We previously reported a novel affinity purification (AP) method termed modified chromatin immunopurification (mChIP), which permits selective enrichment of DNA‐bound proteins along with their associated protein network. In this study, we report a
Externí odkaz:
https://doaj.org/article/7a3e472c202948a0954b19308bf7f673
Autor:
Syed Nabeel-Shah, Jack Greenblatt, Jean-Philippe Lambert, Suzanne Wahab, Zhaolei Zhang, Hyunmin Lee, Jacob Fine, Marcelo Ponce, Ronald E. Pearlman, Edyta Marcon, Jeffrey Fillingham, Nujhat Ahmed, Kanwal Ashraf, Alejandro Saettone, Joanna Derynck, Shuye Pu, Jyoti Garg
Publikováno v:
Nucleic Acids Research
Retinoblastoma-binding proteins 4 and 7 (RBBP4 and RBBP7) are two highly homologous human histone chaperones. They function in epigenetic regulation as subunits of multiple chromatin-related complexes and have been implicated in numerous cancers. Due
Autor:
Jeffrey Fillingham, Jyoti Garg, Alejandro Saettone, Syed Nabeel-Shah, Kanwal Ashraf, Joanna Derynck, Anne-Claude Gingras, Jean-Philippe Lambert, Ronald E. Pearlman
Publikováno v:
Molecular Biology and Evolution
Epigenetic information, which can be passed on independently of the DNA sequence, is stored in part in the form of histone posttranslational modifications and specific histone variants. Although complexes necessary for deposition have been identified