Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jeffrey Fill"'
Autor:
Charles Benson, Emmanuel Chigutsa, Amit Saxena, Paul Klekotka, Peter Chen, Gourab Datta, Ariel Kay, Josh Poorbaugh, Mark J. Mulligan, William A. Fischer, Ying Grace Li, Karen L. Price, Patricia Brown-Augsburger, Ajay Nirula, Robert J. Benschop, Nadine Rouphael, Jenny Y. Chien, Jeffrey Fill, Michael Dougan
Publikováno v:
Clinical Pharmacology and Therapeutics
Therapeutics for patients hospitalized with coronavirus disease 2019 (COVID-19) are urgently needed during the pandemic. Bamlanivimab is a potent neutralizing monoclonal antibody that blocks severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2fc98bbcb8ce46dfce4862bd9a03be5
http://europepmc.org/articles/PMC8653186
http://europepmc.org/articles/PMC8653186
Autor:
Rebecca R. Hozak, Robert W. Siegel, Brendan M Giles, Richard A. Walgren, Kei Muro, Josep Tabernero, Sameera R. Wijayawardana, Kelly R Pitts, Andrew B. Nixon, Eric Van Cutsem, Kentaro Yamazaki, Jeffrey Fill, Kensei Yamaguchi, Hiroya Taniguchi, Abby Jones, Kim R Robling, Nora Drove, Takayuki Yoshino, Paolo Abada
Publikováno v:
Current Medical Research and Opinion. 37:1769-1778
Background Vascular endothelial growth factor (VEGF)-D was identified as a potential predictive biomarker for ramucirumab efficacy in second-line metastatic colorectal cancer using a research use only (RUO) assay. We describe results with a new assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51da34e2be9eaebdcfd9b12d45757249
https://doi.org/10.1080/03007995.2021.1940908
https://doi.org/10.1080/03007995.2021.1940908
Autor:
Jeffrey Fill, Fatima Amanat, Florian Krammer, Vijay Saxena, Andrew L. Schwaderer, Amy C. Wilson, Samuel Arregui, Antonio Chambers, Jack Schneider, David S. Hains, Jenaya Hooks, Michelle C. Starr, Jorge J. Canas, Aaron E. Carroll, Andrew E. Schade
Publikováno v:
Kidney International
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ff5a252377811f5866bdacad5bc7a6f
Autor:
Syed Nabeel-Shah, Jyoti Garg, Kanwal Ashraf, Renu Jeyapala, Hyunmin Lee, Alexandra Petrova, James D. Burns, Shuye Pu, Zhaolei Zhang, Jack F. Greenblatt, Ronald E. Pearlman, Jean-Philippe Lambert, Jeffrey Fillingham
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-22 (2023)
Abstract Background Eukaryotic cells can rapidly adjust their transcriptional profile in response to molecular needs. Such dynamic regulation is, in part, achieved through epigenetic modifications and selective incorporation of histone variants into
Externí odkaz:
https://doaj.org/article/e4f36e6d55c941bfb45b7fa551f9ce48
Autor:
Michael Man, Boris Lin, Jeffrey Fill, Shuaicheng Wang, Brendan M Giles, Kelly R. Pitts, Lisa M Grobeck, Karim A. Benhadji, Diana K. S. Nelson, Timothy T Underwood, Alison Bamberg
Publikováno v:
The journal of applied laboratory medicine. 3(2)
BackgroundThe transforming growth factor β (TGF-β)–signaling pathway has emerged as a promising therapeutic target for many disease states including hepatocellular carcinoma (HCC). Because of the pleiotropic effects of this pathway, patient selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017d5e1e722ab90681cab7d0420da67c
https://pubmed.ncbi.nlm.nih.gov/33636943
https://pubmed.ncbi.nlm.nih.gov/33636943
Autor:
Carlos L. Arteaga, Thomas Daly, Ann Cleverly, Daphne L. Farrington, José Baselga, Michael Lahn, Susanne Kloeker Rhoades, Joan Seoane, Jeffrey Fill, Chad Ray, Brandi Berry, Jonathan M. Yingling, Mace L. Rothenberg, Lisa Anne Wallace, Michael A. Carducci, Josep Tabernero
Publikováno v:
Biomarkers. 13:217-236
We measured transforming growth factor (TGF)-beta-dependent biomarkers in plasma and in peripheral blood mononuclear cells (PBMCs) to identify suitable pharmacodynamic markers for future clinical trials with TGF-beta inhibitors. Forty-nine patients w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a50973a5b40aa6828bf23b2bff54534
https://doi.org/10.1080/13547500701676019
https://doi.org/10.1080/13547500701676019
Autor:
Ian Gourley, Viswanath Devanarayan, Peter J. O'Brien, Carmen M. Dumaual, Mark B. Willey, Chad Ray, Jeffrey Fill, Robert J. Konrad
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 41:189-195
Purpose Measurements of cytokine release in whole blood after ex vivo stimulation are useful in drug development. The components contributing to variation within such assays have not been clearly defined. Therefore, we characterized the sources of va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a5bd6dd225567f0802814564930e52
https://doi.org/10.1016/j.jpba.2005.10.013
https://doi.org/10.1016/j.jpba.2005.10.013
Autor:
Jeffrey Fill, C. F. Lindemann, B. L. Rinehart, R. R. Bowsher, J. J. Komara, M. C. Spence, B. G. Zeiher, J. T. Brandt, H. P. Wiedemann
Publikováno v:
Biomarkers. 11:85-96
Acute lung injury (ALI) is a complex disorder associated with an acute inflammatory response thought to contribute to tissue injury. Desmosine, a cross-linking amino acid present in elastin, is released during matrix degradation and cleared by the ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0e008cd2975884cfec3907b2feb04e
https://doi.org/10.1080/13547500500343225
https://doi.org/10.1080/13547500500343225
Autor:
Robert J. Konrad, Jonathan M. Yingling, Thomas Daly, Yue-Wei Qian, Xiliang Wang, Lei Yan, Shou J, Jeffrey Fill, Ehsani Me, Daphne L. Farrington, Ann Cleverly, Michael Lahn, Chad Ray
Publikováno v:
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 12(3)
Assessing the pharmacodynamics (PD) of a potential therapeutic through the use of a downstream biomarker is essential. This is traditionally performed in the target tissue but limited volume and invasiveness of sampling pose challenges with solid tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2122978624e94f990f63e1bd064c686d
https://pubmed.ncbi.nlm.nih.gov/17453744
https://pubmed.ncbi.nlm.nih.gov/17453744
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-17 (2019)
Abstract Background Chromatin immunoprecipitation coupled to next generation sequencing (ChIP-Seq) is a widely-used molecular method to investigate the function of chromatin-related proteins by identifying their associated DNA sequences on a genomic
Externí odkaz:
https://doaj.org/article/eceafd6ca4fc4ac191dac36ec20fd518