Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jeffrey Durocher"'
Autor:
Peter Qiu, Harini Shandilya, James M. D'Alessio, Kevin O'Connor, Jeffrey Durocher, Gary F. Gerard
Publikováno v:
BioTechniques, Vol 36, Iss 4, Pp 702-707 (2004)
We have developed a simple and flexible mutation detection technology for the discovery and mapping of both known and unknown mutations. This technology is based on a new mismatch-specific DNA endonuclease from celery, Surveyor™ nuclease, which is
Externí odkaz:
https://doaj.org/article/bbd7e094ae3a4c958ed783017e230139
Autor:
Annelie Abrahamsson, Irving L. Weissman, Isabel G. Newton, Jason Gotlib, Francis J. Giles, Armand Keating, Carol D. Jones, Charlene F. Barroga, Mobin Karimi, James L. Zehnder, Remi S. Creusot, Robert S. Negrin, Ifat Geron, Kim-Hien Dao, Jeffrey Durocher, Catriona Jamieson
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 106(10)
Recent evidence suggests that a rare population of self-renewing cancer stem cells (CSC) is responsible for cancer progression and therapeutic resistance. Chronic myeloid leukemia (CML) represents an important paradigm for understanding the genetic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2829eac456febcd8a2a771cb3e8f5af
https://pubmed.ncbi.nlm.nih.gov/19237556
https://pubmed.ncbi.nlm.nih.gov/19237556
Autor:
Jason Gotlib, Edward Kavalerchik, John Hood, Chi Ching Mak, Ifat Geron, Ken Kaushansky, Ayalew Tefferi, Annelie Abrahamsson, Richard Soll, Charlene F. Barroga, Catriona Jamieson, Jeffrey Durocher, Glenn Noronha
Publikováno v:
Cancer Cell. 13(5)
SummaryPolycythemia Vera (PV) is a myeloproliferative disorder (MPD) that is commonly characterized by mutant JAK2 (JAK2V617F) signaling, erythrocyte overproduction, and a propensity for thrombosis, progression to myelofibrosis, or acute leukemia. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6bb5af7bf760898a8930ebb0806324d
Autor:
Stan L. Lilleberg, M. Rajan Mariappan, Mark P. Chao, James L. Zehnder, Jeffrey Durocher, Carol Adaire Jones, Marla Lay, Catriona Jamieson, Jason Gotlib, Irving L. Weissman
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 103(16)
Although a large proportion of patients with polycythemia vera (PV) harbor a valine-to-phenylalanine mutation at amino acid 617 (V617F) in the JAK2 signaling molecule, the stage of hematopoiesis at which the mutation arises is unknown. Here we isolat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76c4bbf0e95429fd7f8fdd5a134ff70
https://pubmed.ncbi.nlm.nih.gov/16603627
https://pubmed.ncbi.nlm.nih.gov/16603627
Autor:
Ching-Cheng Chen, Stephen J. Galli, Caroline Berube, Joseph D. Growney, Len Neckers, D. Gary Gilliland, Tomohiro Kajiguchi, Jeffrey Durocher, Michael Heinrich, Jason Gotlib, Daniel A. Arber, Yanfeng Wang, Steven Coutre, Pamela S. Cohen, Jia Ruan, Stan L. Lilleberg, Jack H. Lichy, Tracy I. George, Christopher R. Williams
Publikováno v:
Blood. 106(8)
The majority of patients with systemic mast cell disease express the imatinib-resistant Asp816Val (D816V) mutation in the KIT receptor tyrosine kinase. Limited treatment options exist for aggressive systemic mastocytosis (ASM) and mast cell leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b4d17722803c0ae18fbb4fb568f46ba
https://pubmed.ncbi.nlm.nih.gov/15972446
https://pubmed.ncbi.nlm.nih.gov/15972446
Autor:
Catriona Jamieson, Isabel G. Newton, Kim-Hien Dao, Robert S. Negrin, Carol D. Jones, Jeffrey Durocher, Mobin Karimi, Annelie Abrahamsson, James L. Zehnder, Armand Keating, Ifat Geron, Francis J. Giles, Edward Kavalerchik, Remi J. Creusot, Jason Gotlib, Irving L. Weissman
Publikováno v:
Blood. 110:775-775
Recent evidence suggests that a rare population of self-renewing cancer stem cells (CSC) is responsible for cancer progression and therapeutic resistance. Chronic myeloid leukemia (CML) represents an important paradigm for understanding the genetic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b8bb348144bac99f1976adb3acdf3b5
https://doi.org/10.1182/blood.v110.11.775.775
https://doi.org/10.1182/blood.v110.11.775.775
Autor:
Kenneth Kaushansky, Edward Kavelerchik, Ayalew Tefferi, Jason Gotlib, Richard Soll, Ifat Geron, John Hood, Charlene F. Barroga, Glen Noronha, Chi Ching Mak, Annelie Abrahamsson, Catriona Jamieson, Jeffrey Durocher
Publikováno v:
Blood. 110:1526-1526
Myeloproliferative disorders (MPDs), diagnosed in 15,000 individuals annually, are characterized by overproduction of lineage-committed blood cells, thrombotic events, occasionally marrow fibrosis or progression to acute myelogenous leukemia and freq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7db5bc10943d50fc45a8b7f3443b2a94
https://doi.org/10.1182/blood.v110.11.1526.1526
https://doi.org/10.1182/blood.v110.11.1526.1526
Aberrant Regulation of Wnt/Beta-Catenin Pathway Mediators in Chronic Myelogenous Leukemia Stem Cells
Autor:
Catriona Jamieson, Ifat Geron, Irving L. Weissman, Jason Gotlib, Remi J. Creusot, C G Fathman, Edward Kavalerchik, Stanley L. Lilleberg, Annelie Abrahamsson, Daniel Goff, Jeffrey Durocher, Francis J. Giles
Publikováno v:
Blood. 108:2135-2135
Background Recent research suggests that self-renewing leukemia stem cells (LSC) with increased beta-catenin expression are involved in chronic myelogenous leukemia (CML) progression. We investigated whether aberrant regulation of beta-catenin destru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e38785f39e1f2948ea8580eb72cc51a
https://doi.org/10.1182/blood.v108.11.2135.2135
https://doi.org/10.1182/blood.v108.11.2135.2135
Autor:
Mark P. Chao, Stan L. Lilleberg, Carol D. Jones, M. Rajan Mariappan, Irving L. Weissman, Jason Gotlib, James L. Zehnder, Steven Coutre, Marla LayRaj, Jeffrey Durocher, Catriona Jamieson
Publikováno v:
Blood. 106:118-118
Myeloproliferative disorders (MPD) are clonal hematopoietic disorders characterized by a hypercellular marrow, an overabundance of distinct lineages of terminally differentiated progeny and a propensity to transform to acute myelogenous leukemia (AML
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9edbcd6892269553a581d2abe6504af
https://doi.org/10.1182/blood.v106.11.118.118
https://doi.org/10.1182/blood.v106.11.118.118
Autor:
Carrie Wasserburger, Jeffrey Durocher, Jill Hempel, Mike L. Nickerson, Manika Sapru Koul, John Troy, Stan L. Lilleberg
Publikováno v:
Blood. 106:4399-4399
The Raf/MEK/ERK, Wnt/beta-catenin, JAK/STAT and PI3K/Akt signal transduction pathways have key roles in the regulation of cell cycle progression and apoptosis, and are current focal points of therapeutic development and intervention strategies for he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::157538f1cc76b85bdd779a87cae6a2b3
https://doi.org/10.1182/blood.v106.11.4399.4399
https://doi.org/10.1182/blood.v106.11.4399.4399