Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Jeffrey Deschamps"'
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Chemistry of the diazeniumdiolates: Z right harpoon over left harpoon E isomerism
Autor: Yan-Ni, Wang, D Scott, Bohle, Challice L, Bonifant, Gwendolyn N, Chmurny, Jack R, Collins, Keith M, Davies, Jeffrey, Deschamps, Judith L, Flippen-Anderson, Larry K, Keefer, John R, Klose, Joseph E, Saavedra, David J, Waterhouse, Joseph, Ivanic
Publikováno v: Journal of the American Chemical Society. 127(15)
Here, we explore the chemistry of the previously undocumented E form of diazeniumdiolates having the structure R(1)R(2)NN(O)=NOR(3). Reported crystallographic studies have uniformly revealed the Z configuration, and our attempts to observe a Z --E co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c98d92629813a2dba224072193224a6d
https://pubmed.ncbi.nlm.nih.gov/15826177
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6
Further structurally constrained analogues of cis-(6-benzhydrylpiperidin-3-yl)benzylamine with elucidation of bioactive conformation: discovery of 1,4-diazabicyclo[3.3.1]nonane derivatives and evaluation of their biological properties for the monoamine transporters
Autor: Jeffrey Deschamps, Charles D Cook, Patrick M. Beardsley, Aloke K. Dutta, Maarten. E. A. Reith, Rohit Kolhatkar, Sujit K. Ghorai
Publikováno v: Journal of medicinal chemistry. 47(21)
Our structure-activity relationship (SAR) study on piperidine analogues for monoamine transporters led to the development of a series of 3,6-disubstituted piperidine derivatives, structurally constrained versions of flexible piperidine analogues, wit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94f2ecdce6beaa68a6932306569a05b
https://pubmed.ncbi.nlm.nih.gov/15456254
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7
General approach for the synthesis of sarpagine indole alkaloids. Enantiospecific total synthesis of (+)-vellosimine, (+)-normacusine B, (-)-alkaloid Q3, (-)-panarine, (+)-Na-methylvellosimine, and (+)-Na-methyl-16-epipericyclivine
Autor: Jianming, Yu, Tao, Wang, Xiaoxiang, Liu, Jeffrey, Deschamps, Judith, Flippen-Anderson, Xuebin, Liao, James M, Cook
Publikováno v: The Journal of organic chemistry. 68(20)
The first total synthesis of (+)-Na-methyl-16-epipericyclivine (9) was completed [from d-(+)-tryptophan methyl ester] in an overall yield of 42% (eight reaction vessels). The optical rotation [[alpha]D +22.8 (c 0.50, CHCl3)] obtained on this material
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b25e1f90d38227f751d90ce8abe913e8
https://pubmed.ncbi.nlm.nih.gov/14510528
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