Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jeffrey D. Zaremba"'
Autor:
Shichun Tu, Mohd Waseem Akhtar, Rosa Maria Escorihuela, Alejandro Amador-Arjona, Vivek Swarup, James Parker, Jeffrey D. Zaremba, Timothy Holland, Neha Bansal, Daniel R. Holohan, Kevin Lopez, Scott D. Ryan, Shing Fai Chan, Li Yan, Xiaofei Zhang, Xiayu Huang, Abdullah Sultan, Scott R. McKercher, Rajesh Ambasudhan, Huaxi Xu, Yuqiang Wang, Daniel H. Geschwind, Amanda J. Roberts, Alexey V. Terskikh, Robert A. Rissman, Eliezer Masliah, Stuart A. Lipton, Nobuki Nakanishi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Human MEF2C haploinsufficiency results in Autism Spectrum Disorder (ASD), but it is unclear if the same is true in mice. Here, the authors show that Mef2c +/− mice have behavioral defects and neuronal abnormalities similar to ASD, and symptoms can
Externí odkaz:
https://doaj.org/article/386d48d4311a447bb8bff05a85d294e7
S-Nitrosylation-Mediated Redox Transcriptional Switch Modulates Neurogenesis and Neuronal Cell Death
Autor:
Shu-ichi Okamoto, Tomohiro Nakamura, Piotr Cieplak, Shing Fai Chan, Evgenia Kalashnikova, Lujian Liao, Sofiyan Saleem, Xuemei Han, Arjay Clemente, Anthony Nutter, Sam Sances, Christopher Brechtel, Daniel Haus, Florian Haun, Sara Sanz-Blasco, Xiayu Huang, Hao Li, Jeffrey D. Zaremba, Jiankun Cui, Zezong Gu, Rana Nikzad, Anne Harrop, Scott R. McKercher, Adam Godzik, John R. Yates III, Stuart A. Lipton
Publikováno v:
Cell Reports, Vol 8, Iss 1, Pp 217-228 (2014)
Redox-mediated posttranslational modifications represent a molecular switch that controls major mechanisms of cell function. Nitric oxide (NO) can mediate redox reactions via S-nitrosylation, representing transfer of an NO group to a critical protein
Externí odkaz:
https://doaj.org/article/5bad9d4b59a14aecaae51657fd3f11ee
Autor:
Zhenrui Liao, Andres Grosmark, Fraser T. Sparks, Patrick Kaifosh, Joseph A. Gogos, Anastasia Diamantopoulou, Attila Losonczy, Nathan Danielson, John C. Bowler, Jeffrey D. Zaremba
Publikováno v:
Nature Neuroscience. 20:1612-1623
Hippocampal place cells represent the cellular substrate of episodic memory. Place cell ensembles reorganize to support learning but must also maintain stable representations to facilitate memory recall. Despite extensive research, the learning-relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88725ab8f9382b23465d3fe775b36def
https://doi.org/10.1038/nn.4634
https://doi.org/10.1038/nn.4634
Autor:
Andrew Lutas, Christian R. Burgess, Kristian Kinden Lensjø, Arthur U. Sugden, Osama Alturkistani, Jeffrey D. Zaremba, Rohan N. Ramesh, Lauren Alpert Sugden, Mark L. Andermann, Kelly L. McGuire
Publikováno v:
Nature neuroscience
Salient experiences are often relived in the mind. Human neuroimaging studies suggest that such experiences drive activity patterns in visual association cortex that are subsequently reactivated during quiet waking. Nevertheless, the circuit-level co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aab565b84878f2c183a89c870ce04c9
https://pubmed.ncbi.nlm.nih.gov/32514136
https://pubmed.ncbi.nlm.nih.gov/32514136
Autor:
Alexander R. Goldberg, Joseph Tsai, Matthew Lovett-Barron, Patrick Kaifosh, Jeffrey D. Zaremba, Mazen A. Kheirbek, Liam Drew, Nathan Danielson, Attila Losonczy, René Hen, Christine A. Denny, Elizabeth M. Balough
Publikováno v:
Neuron. 90:101-112
Adult-born granule cells (abGCs) have been implicated in cognition and mood; however, it remains unknown how these cells behave in vivo. Here, we have used two-photon calcium imaging to monitor the activity of young abGCs in awake behaving mice. We f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893570fd1e52f0302a96e53a83778d08
https://doi.org/10.1016/j.neuron.2016.02.019
https://doi.org/10.1016/j.neuron.2016.02.019
Autor:
Timothy Holland, Abdullah Sultan, Scott R. McKercher, Rajesh Ambasudhan, Eliezer Masliah, Yuqiang Wang, Alexey V. Terskikh, Vivek Swarup, Huaxi Xu, Xiayu Huang, Mohd Waseem Akhtar, Daniel H. Geschwind, James C. Parker, Scott D. Ryan, Amanda J. Roberts, Shichun Tu, Rosa Maria Escorihuela, Xiaofei Zhang, Nobuki Nakanishi, Neha Bansal, Alejandro Amador-Arjona, Stuart A. Lipton, Shing Fai Chan, Li Yan, Kevin M. Lopez, Robert A. Rissman, Jeffrey D. Zaremba, Daniel R. Holohan
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Tu, Shichun; Akhtar, Mohd Waseem; Escorihuela, Rosa Maria; Amador-Arjona, Alejandro; Swarup, Vivek; Parker, James; et al.(2017). NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism.. Nature communications, 8(1), 1488. doi: 10.1038/s41467-017-01563-8. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5127z2zd
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Tu, Shichun; Akhtar, Mohd Waseem; Escorihuela, Rosa Maria; Amador-Arjona, Alejandro; Swarup, Vivek; Parker, James; et al.(2017). NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism.. Nature communications, 8(1), 1488. doi: 10.1038/s41467-017-01563-8. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5127z2zd
Transcription factor MEF2C regulates multiple genes linked to autism spectrum disorder (ASD), and human MEF2C haploinsufficiency results in ASD, intellectual disability, and epilepsy. However, molecular mechanisms underlying MEF2C haploinsufficiency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a166fd27dec67afce13c21feb0e1119
http://europepmc.org/articles/PMC5684358
http://europepmc.org/articles/PMC5684358
Autor:
Attila Losonczy, Mazen A. Kheirbek, René Hen, Thomas Reardon, Patrick Kaifosh, Nathan Danielson, Gergely F. Turi, Jeffrey D. Zaremba, Matthew Lovett-Barron, Boris V. Zemelman
Publikováno v:
Science (New York, N.Y.), vol 343, iss 6173
Fear, Memory, and Place Contextual fear conditioning (CFC) is widely used as a hippocampal-dependent classical conditioning task to model human episodic memory. Lovett-Barron et al. (p. 857 ) combined in vivo imaging with pharmacology, pharmacogeneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cba35861a32a0568ea15eb5caed8369c
https://doi.org/10.1126/science.1247485
https://doi.org/10.1126/science.1247485
Autor:
Eliezer Masliah, Woong Sun, Hyun Jung Kim, Janghwan Kim, Sofiyan Saleem, Scott R. McKercher, Sara Sanz-Blasco, Xiao-Jing Wang, Rajesh Ambasudhan, Saiyong Zhu, Mingliang Zhang, Sheng Ding, Jeffrey D. Zaremba, Yu Zhang, Stuart A. Lipton, Han Seop Kim, Timothy Laurent, James C. Parker, Yee Sook Cho, Maria Talantova
Publikováno v:
Cell Research. 24:126-129
Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0913c25d79129719a80616ebbd21f49
https://doi.org/10.1038/cr.2013.156
https://doi.org/10.1038/cr.2013.156
Autor:
Jeffrey D. Zaremba, Nathan Danielson, Max Ladow, Patrick Kaifosh, John C. Bowler, Attila Losonczy
The mammalian hippocampus is critical for spatial information processing and episodic memory. Its primary output cells, CA1 pyramidal cells (CA1 PCs), vary in genetics, morphology, connectivity, and electrophysiological properties. It is therefore po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793ad15ab0088a75f6c244cc356ff796
https://europepmc.org/articles/PMC4975984/
https://europepmc.org/articles/PMC4975984/
Autor:
Boris V. Zemelman, Attila Losonczy, Jayeeta Basu, Steven A. Siegelbaum, Stephanie Cheung, Jeffrey D. Zaremba, Frederick L. Hitti
Publikováno v:
Science. 351
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d01735a151ac659cd02e5ba8ea42adf
https://doi.org/10.1126/science.aaf2878
https://doi.org/10.1126/science.aaf2878